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- W2791490080 abstract "To investigate imaging response and laboratory parameters as predictors of overall survival (OS) for hepatocellular carcinoma (HCC) treated with yttrium-90 radioembolization (Y90) and to develop a combined scoring system. With IRB approval, we selected all patients that underwent Y90 for HCC (no PVT or metastases) with baseline alpha-fetoprotein (AFP)>100 ng/dl from a prospectively acquired database. Using a previous larger cohort (n = 401), a Laboratory Score [ALBI+(0.3 × LnAFP)] to predict post-Y90 patient OS was developed/validated. This Laboratory Score (simple objective metric) was included in this analysis. Then, we assessed imaging response using a) Response Evaluation Criteria in Solid Tumors (RECIST), b) World Health Organization (WHO), c) European Association for Study of the Liver (EASL) and d) modified RECIST (mRECIST) at baseline and 1-, 3-, and 6-month post-Y90 Landmarks. OS was assessed from these Landmarks using univariate analyses and multivariate Cox regressions. A Combination Score of laboratory parameters and imaging response was developed. Time-dependent receiver operating characteristics were evaluated. 162/178, 113/178, and 69/178 patients had laboratory and imaging parameters available at 1-, 3-, and 6-month Landmarks, respectively. The Laboratory Score and the mRECIST response remained significant at all Landmarks in the multivariate analysis. WHO, RECIST, and EASL response were not significant. We estimated the Combination Score as [ALBI score+(0.3 × LnAFP)+0.005*mRECIST percentage]. The areas under the curves (AUCs) of ROCs of the Imaging Score (mRECIST) vs. Combination Score in predicting OS 1 month post-1-, 3-, and 6-month Landmarks were 0.50 vs. 0.90, 0.65 vs. 0.95, and 0.51 vs. 0.76, respectively; AUCs of predicting OS 3 months post-1-, 3-, and 6-month Landmarks were 0.47 vs. 0.69, 0.61 vs. 0.75, and 0.71 vs. 0.77, respectively. Combining the Laboratory Score and mRECIST response improves post-Y90 OS prognostic ability. This information is helpful in prognostication of survival in patients with HCC." @default.
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- W2791490080 date "2018-04-01" @default.
- W2791490080 modified "2023-09-25" @default.
- W2791490080 title "Abstract No. 549 A score combining imaging response and laboratory prognosticators: survival predictability for hepatocellular carcinoma" @default.
- W2791490080 doi "https://doi.org/10.1016/j.jvir.2018.01.594" @default.
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