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- W2791517803 abstract "Objective: In the present work, a series of five Mannich bases of quinazolinone nucleus synthesized by treating quinazolinones with various aromatic amines.Methods: A series of Mannich bases of quinazolinone synthesized by refluxing quinazolinone with anthranilic acid, amine, and formaldehyde in ethanol. The chemical structures of synthesized compounds were confirmed by thin-layer chromatography using the suitable solvent system and characterized by melting point and IR. The compounds screened for their antibacterial activity and antioxidant activity.Results: Antioxidant activity of the synthesized compounds was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals scavenging method. Compounds II and III showed values at 53% and 36%, respectively, when compared to that of standard ascorbic acid 24% at 10 μg/ml. Compounds II and IV showed excellent activity against Gram-negative organism Escherichia coli using ciprofloxacin as standard.Conclusion: All the synthesized compounds were screened for antimicrobial activity by cup plate by measuring inhibition zone using E. coli at a concentration range of 200–600 mcg/ml, and antioxidant activity was determined by DPPH method." @default.
- W2791517803 created "2018-03-29" @default.
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- W2791517803 date "2018-02-01" @default.
- W2791517803 modified "2023-09-24" @default.
- W2791517803 title "SYNTHESIS AND EVALUATION OF SOME MANNICH BASES OF QUINAZOLINONE NUCLEUS" @default.
- W2791517803 doi "https://doi.org/10.22159/ajpcr.2018.v11i2.22644" @default.
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