Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791565839> ?p ?o ?g. }
- W2791565839 endingPage "6" @default.
- W2791565839 startingPage "1" @default.
- W2791565839 abstract "Alcohol use disorder (AUD) is a leading risk factor of disease burden in the world. It is also commonly comorbid with over 20% of schizophrenia patients. The brain-derived neurotrophic factor (BDNF) and dopamine D3 receptor (DRD3) have been implicated in alcohol drinking behaviour. Previous genetic studies of the BDNF and DRD3 genes produced mixed findings; however, only one study investigated two BDNF genetic markers with alcohol dependence in schizophrenia patients. We investigated 15 single-nucleotide polymorphisms (SNPs) in DRD3 and four SNPs in BDNF for possible association with alcohol abuse or dependence in schizophrenia patients of European ancestry (N = 195). The patients were assessed for the occurrence of alcohol abuse or alcohol dependence using the Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-I/P). We found the BDNF Val66Met to be associated with alcohol dependence (p = 0.004). We also found haplotypes across BDNF to be nominally associated with alcohol dependence. Analyses of DRD3 markers and haplotypes yielded mostly negative findings. Our findings support a role of the BDNF gene in alcohol dependence in schizophrenia patients. Larger samples are required to confirm our findings, particularly those of BDNF haplotypes." @default.
- W2791565839 created "2018-03-29" @default.
- W2791565839 creator A5028939354 @default.
- W2791565839 creator A5039783734 @default.
- W2791565839 creator A5041452359 @default.
- W2791565839 creator A5054181336 @default.
- W2791565839 creator A5056370228 @default.
- W2791565839 creator A5079389435 @default.
- W2791565839 creator A5082315914 @default.
- W2791565839 date "2018-04-01" @default.
- W2791565839 modified "2023-09-24" @default.
- W2791565839 title "Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia" @default.
- W2791565839 cites W117967540 @default.
- W2791565839 cites W1499730254 @default.
- W2791565839 cites W1642086117 @default.
- W2791565839 cites W1656147129 @default.
- W2791565839 cites W1969594906 @default.
- W2791565839 cites W1980243226 @default.
- W2791565839 cites W1981579764 @default.
- W2791565839 cites W1988914865 @default.
- W2791565839 cites W1990942652 @default.
- W2791565839 cites W1993365011 @default.
- W2791565839 cites W1995230642 @default.
- W2791565839 cites W1995254255 @default.
- W2791565839 cites W1996477729 @default.
- W2791565839 cites W1997797784 @default.
- W2791565839 cites W1997906961 @default.
- W2791565839 cites W2006994809 @default.
- W2791565839 cites W2007156391 @default.
- W2791565839 cites W2007687409 @default.
- W2791565839 cites W2009875407 @default.
- W2791565839 cites W2013469364 @default.
- W2791565839 cites W2014813076 @default.
- W2791565839 cites W2017213666 @default.
- W2791565839 cites W2022348270 @default.
- W2791565839 cites W2022569735 @default.
- W2791565839 cites W2024851966 @default.
- W2791565839 cites W2025668071 @default.
- W2791565839 cites W2025699940 @default.
- W2791565839 cites W2027603848 @default.
- W2791565839 cites W2029220352 @default.
- W2791565839 cites W2029565457 @default.
- W2791565839 cites W2029996644 @default.
- W2791565839 cites W2030538260 @default.
- W2791565839 cites W2030705868 @default.
- W2791565839 cites W2036543911 @default.
- W2791565839 cites W2039487967 @default.
- W2791565839 cites W2039517305 @default.
- W2791565839 cites W2046063132 @default.
- W2791565839 cites W2046836464 @default.
- W2791565839 cites W2053478069 @default.
- W2791565839 cites W2055295879 @default.
- W2791565839 cites W2056591616 @default.
- W2791565839 cites W2060690416 @default.
- W2791565839 cites W2066244040 @default.
- W2791565839 cites W2077361954 @default.
- W2791565839 cites W2081260475 @default.
- W2791565839 cites W2105123474 @default.
- W2791565839 cites W2107755054 @default.
- W2791565839 cites W2110052313 @default.
- W2791565839 cites W2112174933 @default.
- W2791565839 cites W2117100209 @default.
- W2791565839 cites W2130417276 @default.
- W2791565839 cites W2139349028 @default.
- W2791565839 cites W2147425235 @default.
- W2791565839 cites W2150098450 @default.
- W2791565839 cites W2150215474 @default.
- W2791565839 cites W2160397887 @default.
- W2791565839 cites W2162530578 @default.
- W2791565839 cites W2164515464 @default.
- W2791565839 cites W2166059093 @default.
- W2791565839 cites W2278912953 @default.
- W2791565839 cites W2317685375 @default.
- W2791565839 cites W2323436072 @default.
- W2791565839 cites W2334233500 @default.
- W2791565839 cites W2552955852 @default.
- W2791565839 cites W2622693920 @default.
- W2791565839 cites W1983239456 @default.
- W2791565839 doi "https://doi.org/10.1016/j.neulet.2018.01.033" @default.
- W2791565839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29357295" @default.
- W2791565839 hasPublicationYear "2018" @default.
- W2791565839 type Work @default.
- W2791565839 sameAs 2791565839 @default.
- W2791565839 citedByCount "11" @default.
- W2791565839 countsByYear W27915658392019 @default.
- W2791565839 countsByYear W27915658392020 @default.
- W2791565839 countsByYear W27915658392022 @default.
- W2791565839 countsByYear W27915658392023 @default.
- W2791565839 crossrefType "journal-article" @default.
- W2791565839 hasAuthorship W2791565839A5028939354 @default.
- W2791565839 hasAuthorship W2791565839A5039783734 @default.
- W2791565839 hasAuthorship W2791565839A5041452359 @default.
- W2791565839 hasAuthorship W2791565839A5054181336 @default.
- W2791565839 hasAuthorship W2791565839A5056370228 @default.
- W2791565839 hasAuthorship W2791565839A5079389435 @default.
- W2791565839 hasAuthorship W2791565839A5082315914 @default.
- W2791565839 hasConcept C104317684 @default.
- W2791565839 hasConcept C118552586 @default.