Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791569425> ?p ?o ?g. }
- W2791569425 endingPage "77" @default.
- W2791569425 startingPage "67" @default.
- W2791569425 abstract "Heterogeneous distribution of drug inside tumor is ubiquitous, causing regional insufficient chemotherapy, which might be the hotbed for drug resistance, tumor cell repopulation and metastasis. Herein, we verify, for the first time, that heterogeneous drug distribution induced insufficient chemotherapy would accelerate the process of epithelial mesenchymal transition (EMT), consequently resulting in the promotion of tumor metastasis. To eliminate the insufficient chemotherapy promoted metastasis, we conceived a co-delivery strategy by hydroxyethyl starch-polylactide (HES-PLA) nanoparticle, in which DOX and TGF-β receptor inhibitor, LY2157299 (LY), were administered together. In vitro and in vivo studies demonstrate that this co-delivery strategy can simultaneously suppress primary tumor and distant metastasis. Further study on immunofluorescence images of primary tumor verifies that low dose of DOX exasperates the EMT process, whereas the co-delivery nanoparticle can dramatically inhibit the progression of EMT. We reveal the impact of heterogeneous drug distribution on tumor metastasis and develop an effective co-delivery strategy to suppress the metastasis, providing guidance for clinical cancer therapy." @default.
- W2791569425 created "2018-03-29" @default.
- W2791569425 creator A5006601393 @default.
- W2791569425 creator A5009596514 @default.
- W2791569425 creator A5011645302 @default.
- W2791569425 creator A5012708855 @default.
- W2791569425 creator A5015807648 @default.
- W2791569425 creator A5018332873 @default.
- W2791569425 creator A5018582393 @default.
- W2791569425 creator A5029849389 @default.
- W2791569425 creator A5029996403 @default.
- W2791569425 creator A5030222851 @default.
- W2791569425 creator A5057751824 @default.
- W2791569425 creator A5076919067 @default.
- W2791569425 creator A5083031620 @default.
- W2791569425 creator A5088654770 @default.
- W2791569425 date "2018-04-01" @default.
- W2791569425 modified "2023-10-14" @default.
- W2791569425 title "Co-delivery nanoparticle to overcome metastasis promoted by insufficient chemotherapy" @default.
- W2791569425 cites W1503388237 @default.
- W2791569425 cites W1963675633 @default.
- W2791569425 cites W1968583232 @default.
- W2791569425 cites W1968762000 @default.
- W2791569425 cites W1977127004 @default.
- W2791569425 cites W1982276721 @default.
- W2791569425 cites W1983345501 @default.
- W2791569425 cites W1987406340 @default.
- W2791569425 cites W2000150008 @default.
- W2791569425 cites W2023944428 @default.
- W2791569425 cites W2040826004 @default.
- W2791569425 cites W2050553656 @default.
- W2791569425 cites W2062929087 @default.
- W2791569425 cites W2063148885 @default.
- W2791569425 cites W2066718759 @default.
- W2791569425 cites W2070269722 @default.
- W2791569425 cites W2074544404 @default.
- W2791569425 cites W2075201743 @default.
- W2791569425 cites W2076985673 @default.
- W2791569425 cites W2077699888 @default.
- W2791569425 cites W2079142824 @default.
- W2791569425 cites W2083232571 @default.
- W2791569425 cites W2092249151 @default.
- W2791569425 cites W2093916414 @default.
- W2791569425 cites W2108333200 @default.
- W2791569425 cites W2114639059 @default.
- W2791569425 cites W2115824449 @default.
- W2791569425 cites W2117692326 @default.
- W2791569425 cites W2118096781 @default.
- W2791569425 cites W2136280424 @default.
- W2791569425 cites W2136615032 @default.
- W2791569425 cites W2137935868 @default.
- W2791569425 cites W2138769328 @default.
- W2791569425 cites W2140740750 @default.
- W2791569425 cites W2146177789 @default.
- W2791569425 cites W2165477639 @default.
- W2791569425 cites W2165487575 @default.
- W2791569425 cites W2165836181 @default.
- W2791569425 cites W2293275625 @default.
- W2791569425 cites W2317179801 @default.
- W2791569425 cites W2334316877 @default.
- W2791569425 cites W2344644350 @default.
- W2791569425 cites W2409322723 @default.
- W2791569425 cites W2468593978 @default.
- W2791569425 cites W2522171581 @default.
- W2791569425 cites W2545028981 @default.
- W2791569425 cites W2548325554 @default.
- W2791569425 cites W2549628327 @default.
- W2791569425 cites W2550902892 @default.
- W2791569425 cites W2590680367 @default.
- W2791569425 cites W2592736432 @default.
- W2791569425 cites W2607268810 @default.
- W2791569425 cites W2615824666 @default.
- W2791569425 cites W2621446704 @default.
- W2791569425 cites W4211233744 @default.
- W2791569425 doi "https://doi.org/10.1016/j.jconrel.2018.02.026" @default.
- W2791569425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29471038" @default.
- W2791569425 hasPublicationYear "2018" @default.
- W2791569425 type Work @default.
- W2791569425 sameAs 2791569425 @default.
- W2791569425 citedByCount "47" @default.
- W2791569425 countsByYear W27915694252018 @default.
- W2791569425 countsByYear W27915694252019 @default.
- W2791569425 countsByYear W27915694252020 @default.
- W2791569425 countsByYear W27915694252021 @default.
- W2791569425 countsByYear W27915694252022 @default.
- W2791569425 countsByYear W27915694252023 @default.
- W2791569425 crossrefType "journal-article" @default.
- W2791569425 hasAuthorship W2791569425A5006601393 @default.
- W2791569425 hasAuthorship W2791569425A5009596514 @default.
- W2791569425 hasAuthorship W2791569425A5011645302 @default.
- W2791569425 hasAuthorship W2791569425A5012708855 @default.
- W2791569425 hasAuthorship W2791569425A5015807648 @default.
- W2791569425 hasAuthorship W2791569425A5018332873 @default.
- W2791569425 hasAuthorship W2791569425A5018582393 @default.
- W2791569425 hasAuthorship W2791569425A5029849389 @default.
- W2791569425 hasAuthorship W2791569425A5029996403 @default.
- W2791569425 hasAuthorship W2791569425A5030222851 @default.
- W2791569425 hasAuthorship W2791569425A5057751824 @default.