Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791645463> ?p ?o ?g. }
- W2791645463 endingPage "6392" @default.
- W2791645463 startingPage "6381" @default.
- W2791645463 abstract "RhoA GTPase plays a variety of functions in regulation of cytoskeletal proteins, cellular morphology, and migration along with various proliferation and transcriptional activity in cells. RhoA activity is regulated by guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and the guanine nucleotide dissociation factor (GDI). The RhoA-RhoGDI complex exists in the cytosol and the active GTP-bound form of RhoA is located to the membrane. GDI displacement factors (GDFs) including IκB kinase γ (IKKγ) dissociate the RhoA-GDI complex, allowing activation of RhoA through GEFs. In addition, modifications of Tyr42 phosphorylation and Cys16/20 oxidation in RhoA and Tyr156 phosphorylation and oxidation of RhoGDI promote the dissociation of the RhoA-RhoGDI complex. The expression of RhoA is regulated through transcriptional factors such as c-Myc, HIF-1α/2α, Stat 6, and NF-κB along with several reported microRNAs. As the role of RhoA in regulating actin-filament formation and myosin-actin interaction has been well described, in this review we focus on the transcriptional activity of RhoA and also the regulation of RhoA message itself. Of interest, in the cytosol, activated RhoA induces transcriptional changes through filamentous actin (F-actin)-dependent (actin switch) or-independent means. RhoA regulates the activity of several transcription regulators such as serum response factor (SRF)/MAL, AP-1, NF-κB, YAP/TAZ, β-catenin, and hypoxia inducible factor (HIF)-1α. Interestingly, RhoA also itself is localized to the nucleus by an as-yet-undiscovered mechanism." @default.
- W2791645463 created "2018-03-29" @default.
- W2791645463 creator A5011325855 @default.
- W2791645463 creator A5012209925 @default.
- W2791645463 creator A5031118788 @default.
- W2791645463 creator A5039074643 @default.
- W2791645463 creator A5045465752 @default.
- W2791645463 creator A5047127136 @default.
- W2791645463 creator A5081816114 @default.
- W2791645463 creator A5089166741 @default.
- W2791645463 date "2018-03-25" @default.
- W2791645463 modified "2023-10-14" @default.
- W2791645463 title "Regulation of RhoA GTPase and various transcription factors in the RhoA pathway" @default.
- W2791645463 cites W1236053900 @default.
- W2791645463 cites W1576177409 @default.
- W2791645463 cites W1608708378 @default.
- W2791645463 cites W1965619419 @default.
- W2791645463 cites W1969200465 @default.
- W2791645463 cites W1969440353 @default.
- W2791645463 cites W1975714506 @default.
- W2791645463 cites W1976145967 @default.
- W2791645463 cites W1978162225 @default.
- W2791645463 cites W1983781249 @default.
- W2791645463 cites W1985929042 @default.
- W2791645463 cites W1993503272 @default.
- W2791645463 cites W1993735775 @default.
- W2791645463 cites W1997335773 @default.
- W2791645463 cites W1997442473 @default.
- W2791645463 cites W1998727354 @default.
- W2791645463 cites W2004130591 @default.
- W2791645463 cites W2004480757 @default.
- W2791645463 cites W2004762438 @default.
- W2791645463 cites W2006473647 @default.
- W2791645463 cites W2007596877 @default.
- W2791645463 cites W2009567773 @default.
- W2791645463 cites W2012915496 @default.
- W2791645463 cites W2013576879 @default.
- W2791645463 cites W2015034924 @default.
- W2791645463 cites W2019012834 @default.
- W2791645463 cites W2019041110 @default.
- W2791645463 cites W2024309614 @default.
- W2791645463 cites W2025519885 @default.
- W2791645463 cites W2029344085 @default.
- W2791645463 cites W2029815774 @default.
- W2791645463 cites W2039057576 @default.
- W2791645463 cites W2047283612 @default.
- W2791645463 cites W2048839248 @default.
- W2791645463 cites W2049976919 @default.
- W2791645463 cites W2052218685 @default.
- W2791645463 cites W2052581434 @default.
- W2791645463 cites W2053257956 @default.
- W2791645463 cites W2056174640 @default.
- W2791645463 cites W2057204732 @default.
- W2791645463 cites W2059166288 @default.
- W2791645463 cites W2060163874 @default.
- W2791645463 cites W2060862744 @default.
- W2791645463 cites W2064760277 @default.
- W2791645463 cites W2065385842 @default.
- W2791645463 cites W2069271377 @default.
- W2791645463 cites W2069945609 @default.
- W2791645463 cites W2070829702 @default.
- W2791645463 cites W2071199281 @default.
- W2791645463 cites W2075256713 @default.
- W2791645463 cites W2078887662 @default.
- W2791645463 cites W2090739732 @default.
- W2791645463 cites W2091082697 @default.
- W2791645463 cites W2091140665 @default.
- W2791645463 cites W2092622990 @default.
- W2791645463 cites W2093723806 @default.
- W2791645463 cites W2093833484 @default.
- W2791645463 cites W2094140080 @default.
- W2791645463 cites W2094962874 @default.
- W2791645463 cites W2100661921 @default.
- W2791645463 cites W2102312968 @default.
- W2791645463 cites W2106143041 @default.
- W2791645463 cites W2108337464 @default.
- W2791645463 cites W2108641962 @default.
- W2791645463 cites W2110935705 @default.
- W2791645463 cites W2116201042 @default.
- W2791645463 cites W2117968545 @default.
- W2791645463 cites W2118825816 @default.
- W2791645463 cites W2121452261 @default.
- W2791645463 cites W2126408367 @default.
- W2791645463 cites W2127697798 @default.
- W2791645463 cites W2130497526 @default.
- W2791645463 cites W2131872235 @default.
- W2791645463 cites W2133415297 @default.
- W2791645463 cites W2133424481 @default.
- W2791645463 cites W2134807132 @default.
- W2791645463 cites W2140248432 @default.
- W2791645463 cites W2143936341 @default.
- W2791645463 cites W2145368725 @default.
- W2791645463 cites W2145996164 @default.
- W2791645463 cites W2146146853 @default.
- W2791645463 cites W2151777574 @default.
- W2791645463 cites W2157649286 @default.
- W2791645463 cites W2159038842 @default.
- W2791645463 cites W2164378264 @default.