Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791659830> ?p ?o ?g. }
- W2791659830 endingPage "61" @default.
- W2791659830 startingPage "50" @default.
- W2791659830 abstract "Humanized mice are increasingly appreciated as an incredibly powerful platform for infectious disease research. The often very narrow species tropism of many viral infections, coupled with the sometimes misleading results from preclinical studies in animal models further emphasize the need for more predictive model systems based on human cells rather than surrogates. Humanized mice represent such a model and have been greatly enhanced with regards to their immune system reconstitution as well as immune functionality in the past years, resulting in their recommendation as a preclinical model by the US Food and Drug Administration. This review aims to give a detailed summary of the generation of human peripheral blood lymphocyte-, CD34+ haematopoietic stem cell- and bone marrow/liver/thymus-reconstituted mice and available improved models (e.g. myeloid- or T-cell-only mice, MISTRG, NSG-SGM3). Additionally, we summarize human-tropic viral infections, for which humanized mice offer a novel approach for the study of disease pathogenesis as well as future perspectives for their use in biomedical, drug and vaccine research." @default.
- W2791659830 created "2018-03-29" @default.
- W2791659830 creator A5000320110 @default.
- W2791659830 creator A5057340683 @default.
- W2791659830 creator A5077214934 @default.
- W2791659830 date "2018-03-09" @default.
- W2791659830 modified "2023-10-10" @default.
- W2791659830 title "A Hitchhiker's guide to humanized mice: new pathways to studying viral infections" @default.
- W2791659830 cites W1545439267 @default.
- W2791659830 cites W15596631 @default.
- W2791659830 cites W1952297410 @default.
- W2791659830 cites W1967492226 @default.
- W2791659830 cites W1969100298 @default.
- W2791659830 cites W197019882 @default.
- W2791659830 cites W1970910239 @default.
- W2791659830 cites W1973434464 @default.
- W2791659830 cites W1973436972 @default.
- W2791659830 cites W1976165637 @default.
- W2791659830 cites W1976701849 @default.
- W2791659830 cites W1977809195 @default.
- W2791659830 cites W1985623294 @default.
- W2791659830 cites W1987499438 @default.
- W2791659830 cites W1988125746 @default.
- W2791659830 cites W1989877475 @default.
- W2791659830 cites W1993365997 @default.
- W2791659830 cites W1994642652 @default.
- W2791659830 cites W2000127829 @default.
- W2791659830 cites W2000995475 @default.
- W2791659830 cites W2002987798 @default.
- W2791659830 cites W2003466425 @default.
- W2791659830 cites W2007987850 @default.
- W2791659830 cites W2009888206 @default.
- W2791659830 cites W2014725234 @default.
- W2791659830 cites W2020085254 @default.
- W2791659830 cites W2023251537 @default.
- W2791659830 cites W2024446294 @default.
- W2791659830 cites W2036606193 @default.
- W2791659830 cites W2037010689 @default.
- W2791659830 cites W2038359563 @default.
- W2791659830 cites W2038363431 @default.
- W2791659830 cites W2053006144 @default.
- W2791659830 cites W2056537073 @default.
- W2791659830 cites W2061217859 @default.
- W2791659830 cites W2061600924 @default.
- W2791659830 cites W2067114333 @default.
- W2791659830 cites W2067935354 @default.
- W2791659830 cites W2069264717 @default.
- W2791659830 cites W2078066011 @default.
- W2791659830 cites W2080441857 @default.
- W2791659830 cites W2082491973 @default.
- W2791659830 cites W2088935507 @default.
- W2791659830 cites W2096860032 @default.
- W2791659830 cites W2099709298 @default.
- W2791659830 cites W2102364227 @default.
- W2791659830 cites W2106832715 @default.
- W2791659830 cites W2108460245 @default.
- W2791659830 cites W2120782949 @default.
- W2791659830 cites W2121296127 @default.
- W2791659830 cites W2124056936 @default.
- W2791659830 cites W2128111454 @default.
- W2791659830 cites W2128234350 @default.
- W2791659830 cites W2130893462 @default.
- W2791659830 cites W2131432646 @default.
- W2791659830 cites W2139050492 @default.
- W2791659830 cites W2140489687 @default.
- W2791659830 cites W2144980184 @default.
- W2791659830 cites W2152575383 @default.
- W2791659830 cites W2157562991 @default.
- W2791659830 cites W2157908499 @default.
- W2791659830 cites W2159465679 @default.
- W2791659830 cites W2160146754 @default.
- W2791659830 cites W2168248700 @default.
- W2791659830 cites W2172093416 @default.
- W2791659830 cites W2189453751 @default.
- W2791659830 cites W2261436934 @default.
- W2791659830 cites W2271750147 @default.
- W2791659830 cites W2294972389 @default.
- W2791659830 cites W2296527675 @default.
- W2791659830 cites W229691238 @default.
- W2791659830 cites W2327451194 @default.
- W2791659830 cites W2328924450 @default.
- W2791659830 cites W2336129655 @default.
- W2791659830 cites W2342787373 @default.
- W2791659830 cites W2399143306 @default.
- W2791659830 cites W2411578477 @default.
- W2791659830 cites W2462614404 @default.
- W2791659830 cites W2510151332 @default.
- W2791659830 cites W2510235446 @default.
- W2791659830 cites W2528397974 @default.
- W2791659830 cites W2529884397 @default.
- W2791659830 cites W2537705582 @default.
- W2791659830 cites W2572655490 @default.
- W2791659830 cites W2604957558 @default.
- W2791659830 cites W2606314694 @default.
- W2791659830 cites W2606613626 @default.
- W2791659830 cites W2613179277 @default.
- W2791659830 cites W2618508203 @default.
- W2791659830 cites W2735553409 @default.