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• W27916614 endingPage "204" @default.
• W27916614 startingPage "171" @default.
• W27916614 abstract "My aim in this chapter is to discuss some of the general mechanisms involved in cardiac inotropy and their relationship with cellular Ca overload. I do not plan to provide a comprehensive review of either inotropic agents or cardiac pathophysiology. I will start by considering four fundamentally different examples of cardiac inotropy: 1) β-adrenergic activation, 2) α-adrenergic activation, 3) hypothermia and 3) cardioactive steroids (digitalis glycosides). Then I will discuss the ways in which intracellular Ca metabolism can go awry, with particular emphasis on Ca overload. Finally, I will address strategic sites for induction of cardiac inotropy. These discussions may help to bring some of the characteristics of specific cellular systems discussed in preceding chapters into a more integrative picture of cellular Ca regulation." @default.
• W27916614 created "2016-06-24" @default.
• W27916614 creator A5020824899 @default.
• W27916614 date "1993-01-01" @default.
• W27916614 modified "2023-10-12" @default.
• W27916614 title "Cardiac Inotropy and Ca Overload" @default.
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