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- W2791692044 abstract "Reactive carbonyls (RCs), which are inevitably produced during respiratory and photosynthetic metabolism, have the potential to cause oxidative damage to photosynthetic organisms. Previously, we proposed a scavenging model for RCs in the cyanobacterium Synechocystis sp. PCC 6803 (S. 6803). In the current study, we constructed mutants deficient in the enzymes medium‐chain dehydrogenase/reductase (ΔMDR) and aldo‐keto reductase (ΔAKR) to investigate their contributions to RC scavenging in vivo . We found that treatment with the lipid‐derived RC acrolein causes growth inhibition and promotes greater protein carbonylation in ΔMDR, compared with the wild‐type and ΔAKR. In both ΔMDR and ΔAKR, photosynthesis is severely inhibited in the presence of acrolein. These results suggest that these enzymes function as part of the scavenging systems for RCs in S. 6803 in vivo ." @default.
- W2791692044 created "2018-03-29" @default.
- W2791692044 creator A5005329799 @default.
- W2791692044 creator A5047878163 @default.
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- W2791692044 date "2018-02-23" @default.
- W2791692044 modified "2023-10-14" @default.
- W2791692044 title "Medium‐chain dehydrogenase/reductase and aldo‐keto reductase scavenge reactive carbonyls in <i>Synechocystis</i> sp. PCC 6803" @default.
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- W2791692044 doi "https://doi.org/10.1002/1873-3468.13003" @default.
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