Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791717870> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2791717870 endingPage "121" @default.
- W2791717870 startingPage "117" @default.
- W2791717870 abstract "The mechanism of kolaviron-induced vascular smooth muscles (VSMs) responses has not been fullycharacterised. The present study investigated the effect and mode of action of kolaviron a biflavanoid-complex and majorcomponent of Garcinia Kola-fraction on differential contractile responses to agonists-[phenylephrine (PHE) and histamine(HIST)] on VSMs of rabbit isolated aortic rings in K+-free physiological salt solution (KFPSS). Cumulative concentrationresponses to PHE and HIST were examined on 2 mm ring segments of the thoracic aortae which were suspended in 20 mlorgan baths containing physiological salt solution (PSS) for measurement of isometric contractions, at 370C and pH 7.4. Themedium was bubbled with 95% O2, 5% CO2, and rings were given an initial load of 1g. Cumulative contractile responses tothe agonists were studied in normal PSS (control) and following 30 minutes exposure to K+-free PSS and/or 800µg/mLkolaviron. Contractile responses were expressed as percentage of 80 mM K+ contractions in normal PSS. Maximalcontractions (Emax) induced by PHE and HIST compared with high K+ contraction in the various preparations weredifferentially altered following exposure to K+-free or 800µg/mL kolaviron in both intact (+E) and endotheliumdenuded (-E) rings. Based on the efficacy (Emax) and potency (EC50) values for the dose-response curves of the agonists, it isconcluded that enhanced differential contractile responses elicited by agonists in K+-free PSS were significantly attenuatedby kolaviron concentration-dependently. This observation probably suggests the existence of another pathway of kolavironmode of action in vascular smooth muscle reactivity." @default.
- W2791717870 created "2018-03-29" @default.
- W2791717870 creator A5036588576 @default.
- W2791717870 creator A5047635916 @default.
- W2791717870 date "2017-12-30" @default.
- W2791717870 modified "2023-09-23" @default.
- W2791717870 title "Differential Kolaviron Attenuated Contractile Responses to Agonists on Isolated Rabbit Aorta in Na+-K+ Pump Blockade." @default.
- W2791717870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29485630" @default.
- W2791717870 hasPublicationYear "2017" @default.
- W2791717870 type Work @default.
- W2791717870 sameAs 2791717870 @default.
- W2791717870 citedByCount "0" @default.
- W2791717870 crossrefType "journal-article" @default.
- W2791717870 hasAuthorship W2791717870A5036588576 @default.
- W2791717870 hasAuthorship W2791717870A5047635916 @default.
- W2791717870 hasConcept C103486182 @default.
- W2791717870 hasConcept C1122143 @default.
- W2791717870 hasConcept C126322002 @default.
- W2791717870 hasConcept C163415756 @default.
- W2791717870 hasConcept C170493617 @default.
- W2791717870 hasConcept C185592680 @default.
- W2791717870 hasConcept C202751555 @default.
- W2791717870 hasConcept C2777952589 @default.
- W2791717870 hasConcept C2778468042 @default.
- W2791717870 hasConcept C2779395532 @default.
- W2791717870 hasConcept C2779980429 @default.
- W2791717870 hasConcept C2992686903 @default.
- W2791717870 hasConcept C55493867 @default.
- W2791717870 hasConcept C57992300 @default.
- W2791717870 hasConcept C71924100 @default.
- W2791717870 hasConcept C84393581 @default.
- W2791717870 hasConcept C98274493 @default.
- W2791717870 hasConceptScore W2791717870C103486182 @default.
- W2791717870 hasConceptScore W2791717870C1122143 @default.
- W2791717870 hasConceptScore W2791717870C126322002 @default.
- W2791717870 hasConceptScore W2791717870C163415756 @default.
- W2791717870 hasConceptScore W2791717870C170493617 @default.
- W2791717870 hasConceptScore W2791717870C185592680 @default.
- W2791717870 hasConceptScore W2791717870C202751555 @default.
- W2791717870 hasConceptScore W2791717870C2777952589 @default.
- W2791717870 hasConceptScore W2791717870C2778468042 @default.
- W2791717870 hasConceptScore W2791717870C2779395532 @default.
- W2791717870 hasConceptScore W2791717870C2779980429 @default.
- W2791717870 hasConceptScore W2791717870C2992686903 @default.
- W2791717870 hasConceptScore W2791717870C55493867 @default.
- W2791717870 hasConceptScore W2791717870C57992300 @default.
- W2791717870 hasConceptScore W2791717870C71924100 @default.
- W2791717870 hasConceptScore W2791717870C84393581 @default.
- W2791717870 hasConceptScore W2791717870C98274493 @default.
- W2791717870 hasIssue "2" @default.
- W2791717870 hasLocation W27917178701 @default.
- W2791717870 hasOpenAccess W2791717870 @default.
- W2791717870 hasPrimaryLocation W27917178701 @default.
- W2791717870 hasRelatedWork W1974520470 @default.
- W2791717870 hasRelatedWork W2017589268 @default.
- W2791717870 hasRelatedWork W2037245897 @default.
- W2791717870 hasRelatedWork W2087860106 @default.
- W2791717870 hasRelatedWork W2222375886 @default.
- W2791717870 hasRelatedWork W2296750929 @default.
- W2791717870 hasRelatedWork W2314941988 @default.
- W2791717870 hasRelatedWork W2404470327 @default.
- W2791717870 hasRelatedWork W2465853351 @default.
- W2791717870 hasRelatedWork W3181060345 @default.
- W2791717870 hasVolume "32" @default.
- W2791717870 isParatext "false" @default.
- W2791717870 isRetracted "false" @default.
- W2791717870 magId "2791717870" @default.
- W2791717870 workType "article" @default.