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- W2791798783 abstract "Abstract The major histocompatibility complex ( MHC ) class‐I related molecule MR 1 is a monomorphic and evolutionary conserved antigen (Ag)‐presenting molecule that shares the overall architecture of MHC ‐I and CD 1 proteins. However, in contrast to MHC ‐I and the CD 1 family that present peptides and lipids, respectively, MR 1 specifically presents small organic molecules. During microbial infection of mammalian cells, MR 1 captures and presents vitamin B precursors, derived from the microbial biosynthesis of riboflavin, on the surface of antigen‐presenting cells. These MR 1‐Ag complexes are recognized by the mucosal‐associated invariant T cell receptor ( MAIT TCR ), which subsequently leads to MAIT cell activation. Recently, MR 1 was shown to trap chemical scaffolds including drug and drug‐like molecules. Here, we review this metabolite Ag‐presenting molecule and further define the key molecular interactions underlying the recognition and reactivity of MAIT TCR s to MR 1 in an Ag‐dependent manner." @default.
- W2791798783 created "2018-03-29" @default.
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- W2791798783 date "2018-02-27" @default.
- W2791798783 modified "2023-10-03" @default.
- W2791798783 title "Mucosal‐associated invariant T cell receptor recognition of small molecules presented by <scp>MR</scp> 1" @default.
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- W2791798783 doi "https://doi.org/10.1111/imcb.12017" @default.
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