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• W2791817975 endingPage "e0191019" @default.
• W2791817975 startingPage "e0191019" @default.
• W2791817975 abstract "We have reconstructed small parts of capillary networks in the human splenic white pulp using serial sections immunostained for CD34 alone or for CD34 and CD271. The three-dimensional (3D) models show three types of interconnected networks: a network with very few long capillaries inside the white pulp originating from central arteries, a denser network surrounding follicles plus periarterial T-cell regions and a network in the red pulp. Capillaries of the perifollicular network and the red pulp network have open ends. Perifollicular capillaries form an arrangement similar to a basketball net located in the outer marginal zone. The marginal zone is defined by MAdCAM-1+ marginal reticular stromal cells. Perifollicular capillaries are connected to red pulp capillaries surrounded by CD271+ stromal capillary sheath cells. The scarcity of capillaries inside the splenic white pulp is astonishing, as non-polarised germinal centres with proliferating B-cells occur in adult human spleens. We suggest that specialized stromal marginal reticular cells form a barrier inside the splenic marginal zone, which together with the scarcity of capillaries guarantees the maintenance of gradients necessary for positioning of migratory B- and T-lymphocytes in the human splenic white pulp." @default.
• W2791817975 created "2018-03-29" @default.
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• W2791817975 date "2018-02-08" @default.
• W2791817975 modified "2023-10-15" @default.
• W2791817975 title "Capillary networks and follicular marginal zones in human spleens. Three-dimensional models based on immunostained serial sections" @default.
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• W2791817975 doi "https://doi.org/10.1371/journal.pone.0191019" @default.
• W2791817975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5805169" @default.
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