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• W2791831005 abstract "Sepsis commonly results in acute and chronic brain dysfunction, which dramatically increases the morbidity associated with this common disease. Chronic brain dysfunction in animal models of sepsis survival is linked to persistent neuroinflammation and expression of multiple cytokines. However, we have found previously that microglia predominantly upregulate the damage associated molecule S100A8/A9 after sepsis. In this article, we show that S100A8/A9 is increased in the brains of patients who died of sepsis and that S100A8 is expressed in astrocytes and myeloid cells. Using a mouse model of sepsis survival, we show that S100A8/A9 is persistently expressed in the brain after sepsis. S100A9 expression is necessary for recruitment of neutrophils to the brain and for priming production of reactive oxygen species and TNF-α secretion in microglia and macrophages. However, despite improving these indices of chronic inflammation, S100A9 deficiency results in worsened anxiety-like behavior 2 wk after sepsis. Taken together, these results indicate that S100A8/A9 contributes to several facets of neuroinflammation in sepsis survivor mice, including granulocyte recruitment and priming of microglial-reactive oxygen species and cytokine production, and that these processes may be protective against anxiety behavior in sepsis survivors." @default.
• W2791831005 created "2018-03-29" @default.
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• W2791831005 date "2018-05-01" @default.
• W2791831005 modified "2023-10-16" @default.
• W2791831005 title "S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis" @default.
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• W2791831005 cites W1831407487 @default.
• W2791831005 cites W1967278969 @default.
• W2791831005 cites W1967968285 @default.
• W2791831005 cites W1970943114 @default.
• W2791831005 cites W1972400820 @default.
• W2791831005 cites W1985315203 @default.
• W2791831005 cites W1986830129 @default.
• W2791831005 cites W1993936714 @default.
• W2791831005 cites W1994780420 @default.
• W2791831005 cites W2011623901 @default.
• W2791831005 cites W2013181947 @default.
• W2791831005 cites W2014941569 @default.
• W2791831005 cites W2015329932 @default.
• W2791831005 cites W2022151953 @default.
• W2791831005 cites W2029216908 @default.
• W2791831005 cites W2041308303 @default.
• W2791831005 cites W2041439089 @default.
• W2791831005 cites W2051083932 @default.
• W2791831005 cites W2053095277 @default.
• W2791831005 cites W2053189438 @default.
• W2791831005 cites W2056575371 @default.
• W2791831005 cites W2057142271 @default.
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• W2791831005 cites W2097599737 @default.
• W2791831005 cites W2103491454 @default.
• W2791831005 cites W2104003768 @default.
• W2791831005 cites W2108485082 @default.
• W2791831005 cites W2113058827 @default.
• W2791831005 cites W2113107925 @default.
• W2791831005 cites W2117979840 @default.
• W2791831005 cites W2126503106 @default.
• W2791831005 cites W2127723018 @default.
• W2791831005 cites W2127941720 @default.
• W2791831005 cites W2133610914 @default.
• W2791831005 cites W2138372479 @default.
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• W2791831005 cites W2144152742 @default.
• W2791831005 cites W2147473688 @default.
• W2791831005 cites W2148021221 @default.
• W2791831005 cites W2153406260 @default.
• W2791831005 cites W2155556701 @default.
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• W2791831005 cites W2159443316 @default.
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• W2791831005 cites W2169457325 @default.
• W2791831005 cites W2170886136 @default.
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• W2791831005 cites W2266546441 @default.
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• W2791831005 cites W2316769215 @default.
• W2791831005 cites W2320486431 @default.
• W2791831005 cites W2340192487 @default.
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• W2791831005 cites W2504925882 @default.
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• W2791831005 doi "https://doi.org/10.4049/jimmunol.1700834" @default.
• W2791831005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5915914" @default.
• W2791831005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29563178" @default.
• W2791831005 hasPublicationYear "2018" @default.
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