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• W2791907327 abstract "Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the human malarial parasite Plasmodium falciparum. We describe here the synthesis of a series of analogues of TQ that explore the potential for nitrogen-substitution to this scaffold, or reduction to a hydroquinone scaffold, in increasing the potency of this antiproliferative activity against ovarian cancer cell lines and P. falciparum. In addition, alkyl or halogen-substituted analogues were commercially sourced and tested in parallel. Several TQ analogues with improved potency against ovarian cancer cells and P. falciparum were found, although this increase is suggested to be moderate. Key aspects of the structure activity relationship that could be further explored are highlighted." @default.
• W2791907327 created "2018-03-29" @default.
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• W2791907327 date "2018-04-01" @default.
• W2791907327 modified "2023-10-03" @default.
• W2791907327 title "The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents" @default.
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• W2791907327 doi "https://doi.org/10.1016/j.bmcl.2018.02.051" @default.
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