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- W279191 abstract "To obtain relevant data on silent lesions found in health screening of the brain, we analyzed findigns on magnetic resonance imaging in 539 community dwelling elderly subjects with a mean age of 66 years. The prevalence of silent brain infarction and deep white matter lesions were 12.4% and 32.1%, respectively. Multivariate analysis with a logistic regression model revealed that silent brain infarction was significantly associated with age, male gender, and hypertension. Recently, elevated plasma homocysteine levels were suggested to be an independent risk factor for silent brain infarction. Particular attention should be payed to such potentially treatable or modifiable factors for ischemic lesions in the setting of health screening of the brain. With regard to deep white matter lesions, data on prevalence or pathogenetic factors are often controversial. One source of conflicting results in white matter hyperintensities on magnetic resonance imaging would be the differences in visual rating scale. In our experience, multivariate analysis revealed that deep white matter lesions were significantly associated with age, hypertension, total cholesterol, and decreased plasma tryptophan concentrations. A further important point in health screening of the brain is an early detection of cognitive decline at its mild stage to prevent the future development of dementia. Based on the clinical evidence accumulated in health screening of the brain, we need to work out a better strategy of preventing subsequent symptomatic stroke or vascular cognitive impairment." @default.
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- W279191 date "2002-01-01" @default.
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- W279191 title "Deep white matter lesions and silent ischemic stroke detected by magnetic resonance imaging in community dwelling elderly subjects" @default.
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- W279191 doi "https://doi.org/10.3995/jstroke.24.335" @default.
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