Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791910068> ?p ?o ?g. }
- W2791910068 endingPage "268" @default.
- W2791910068 startingPage "257" @default.
- W2791910068 abstract "Lead (Pb) is one of the ubiquitous and toxic elements in aquatic environment. In oysters, gills and digestive glands are the main target organs for Pb-induced toxicity, but there is limited information on the molecular mechanisms underlying its toxicity. The present study investigated the Pb-induced toxicity mechanisms in the Pacific oyster (Crassostrea gigas) based on transcriptome, phenotypic anchoring, and validation of targeted gene expression. Gene ontology and pathway enrichment analyses revealed the differential Pb toxicity mechanisms in the tissues. In the gills, Pb disturbed the protein metabolism, with the most significant enrichment of the protein processing in endoplasmic reticulum pathway. The main mechanism comprised of a Pb-stimulated calcium (Ca2+) increase by the up-regulation of transporter-Ca-ATPase expression. The disturbed Ca2+ homeostasis then further induced high expressions of endoplasmic reticulum (ER) chaperones, leading to ER stress in the oysters. Unfolded proteins induced ER associated degradation (ERAD), thereby preventing the accumulation of folding-incompetent glycoproteins. However, Pb mainly induced oxidative reduction reactions in the digestive gland with high accumulation of lipid peroxidation products and high expression of antioxidant enzymes. Further, Pb induced fatty acid β-oxidation and CYP450 catalyzed ω-oxidation due to increased metabolic expenditure for detoxification. The increased content of arachidonic acid indicated that Pb exposure might alter unsaturated fatty acid composition and disturb cellular membrane functions. Taken together, our results provided a new insight into the molecular mechanisms underlying Pb toxicity in oysters." @default.
- W2791910068 created "2018-03-29" @default.
- W2791910068 creator A5027475930 @default.
- W2791910068 creator A5038779010 @default.
- W2791910068 creator A5041421315 @default.
- W2791910068 creator A5066308891 @default.
- W2791910068 date "2018-05-01" @default.
- W2791910068 modified "2023-10-01" @default.
- W2791910068 title "Tissue-specific molecular and cellular toxicity of Pb in the oyster ( Crassostrea gigas ): mRNA expression and physiological studies" @default.
- W2791910068 cites W1534485329 @default.
- W2791910068 cites W1600229840 @default.
- W2791910068 cites W1953598538 @default.
- W2791910068 cites W1960995031 @default.
- W2791910068 cites W1964354937 @default.
- W2791910068 cites W1964706050 @default.
- W2791910068 cites W1965261736 @default.
- W2791910068 cites W1966927202 @default.
- W2791910068 cites W1967112367 @default.
- W2791910068 cites W1967464752 @default.
- W2791910068 cites W1969593544 @default.
- W2791910068 cites W1974116356 @default.
- W2791910068 cites W1974182758 @default.
- W2791910068 cites W1974435153 @default.
- W2791910068 cites W19744801 @default.
- W2791910068 cites W1975795229 @default.
- W2791910068 cites W1983020048 @default.
- W2791910068 cites W1985421585 @default.
- W2791910068 cites W1985458708 @default.
- W2791910068 cites W1989181408 @default.
- W2791910068 cites W1989911237 @default.
- W2791910068 cites W1990949119 @default.
- W2791910068 cites W1994547012 @default.
- W2791910068 cites W1997542997 @default.
- W2791910068 cites W2008097708 @default.
- W2791910068 cites W2010620003 @default.
- W2791910068 cites W2018147178 @default.
- W2791910068 cites W2020469902 @default.
- W2791910068 cites W2023501228 @default.
- W2791910068 cites W2024141160 @default.
- W2791910068 cites W2025296211 @default.
- W2791910068 cites W2027480467 @default.
- W2791910068 cites W2029598860 @default.
- W2791910068 cites W2032756454 @default.
- W2791910068 cites W2040136224 @default.
- W2791910068 cites W2045394310 @default.
- W2791910068 cites W2046866984 @default.
- W2791910068 cites W2047814923 @default.
- W2791910068 cites W2050573290 @default.
- W2791910068 cites W2053471764 @default.
- W2791910068 cites W2054795269 @default.
- W2791910068 cites W2055708764 @default.
- W2791910068 cites W2060574598 @default.
- W2791910068 cites W2061986532 @default.
- W2791910068 cites W2063041403 @default.
- W2791910068 cites W2064093127 @default.
- W2791910068 cites W2066655356 @default.
- W2791910068 cites W2066765509 @default.
- W2791910068 cites W2072273676 @default.
- W2791910068 cites W2073655872 @default.
- W2791910068 cites W2074196246 @default.
- W2791910068 cites W2074630416 @default.
- W2791910068 cites W2074653853 @default.
- W2791910068 cites W2075488370 @default.
- W2791910068 cites W2078480467 @default.
- W2791910068 cites W2079295499 @default.
- W2791910068 cites W2079731478 @default.
- W2791910068 cites W2084518640 @default.
- W2791910068 cites W2085206136 @default.
- W2791910068 cites W2094256135 @default.
- W2791910068 cites W2095218165 @default.
- W2791910068 cites W2097065948 @default.
- W2791910068 cites W2101278086 @default.
- W2791910068 cites W2101982676 @default.
- W2791910068 cites W2110223162 @default.
- W2791910068 cites W2110284555 @default.
- W2791910068 cites W2115885669 @default.
- W2791910068 cites W2121490408 @default.
- W2791910068 cites W2122974119 @default.
- W2791910068 cites W2126595031 @default.
- W2791910068 cites W2131118500 @default.
- W2791910068 cites W2132897895 @default.
- W2791910068 cites W2137662702 @default.
- W2791910068 cites W2151699770 @default.
- W2791910068 cites W2171588737 @default.
- W2791910068 cites W2214020969 @default.
- W2791910068 cites W2290177109 @default.
- W2791910068 cites W2326839938 @default.
- W2791910068 cites W234151133 @default.
- W2791910068 cites W2406517811 @default.
- W2791910068 cites W2425607623 @default.
- W2791910068 cites W243896188 @default.
- W2791910068 cites W2502818374 @default.
- W2791910068 cites W2514717725 @default.
- W2791910068 cites W2604255034 @default.
- W2791910068 cites W2624433879 @default.
- W2791910068 cites W2755220848 @default.
- W2791910068 cites W42817031 @default.
- W2791910068 cites W955177007 @default.