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- W2791923357 abstract "T cell malignancies represent a group of hematologic cancers with high rates of relapse and mortality in patients for whom no effective targeted therapies exist. The shared expression of target antigens between chimeric antigen receptor (CAR) T cells and malignant T cells has limited the development of CAR-T because of unintended CAR-T fratricide and an inability to harvest sufficient autologous T cells. Here, we describe a fratricide-resistant off-the-shelf CAR-T (or UCART7) that targets CD7+ T cell malignancies and, through CRISPR/Cas9 gene editing, lacks both CD7 and T cell receptor alpha chain (TRAC) expression. UCART7 demonstrates efficacy against human T cell acute lymphoblastic leukemia (T-ALL) cell lines and primary T-ALL in vitro and in vivo without the induction of xenogeneic GvHD. Fratricide-resistant, allo-tolerant off-the-shelf CAR-T represents a strategy for treatment of relapsed and refractory T-ALL and non-Hodgkin's T cell lymphoma without a requirement for autologous T cells." @default.
- W2791923357 created "2018-03-29" @default.
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- W2791923357 date "2018-02-20" @default.
- W2791923357 modified "2023-10-15" @default.
- W2791923357 title "An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies" @default.
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- W2791923357 doi "https://doi.org/10.1038/s41375-018-0065-5" @default.
- W2791923357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6102094" @default.
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