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- W2791930922 abstract "Evolution of adaptive phenotypic flexibility requires a system that can dynamically restore and update a functional phenotype in response to environmental change. The architecture of such a system evolves under the conflicting demands of versatility and robustness, and resolution of these demands should be particularly evident in organisms that require external inputs for reiterative trait production within a generation, such as in metabolic networks that underlie yearly acquisition of diet-dependent coloration in birds. Here, we show that a key structural feature of carotenoid networks-redundancy of biochemical pathways-enables these networks to translate variable environmental inputs into consistent phenotypic outcomes. We closely followed life-long changes in structure and utilization of metabolic networks in a large cohort of free-living birds and found that greater individual experience with dietary change between molts leads to wider occupancy of the metabolic network and progressive accumulation of redundant pathways in a functionally active network. This generated a regime of emergent buffering whereby greater dietary experience was mechanistically linked to greater robustness of resulting traits and an increasing ability to retain and implement previous adaptive solutions. Thus, experience-related buffering links evolvability and robustness in carotenoid-metabolizing networks and we argue that this mechanistic principle facilitates the evolution of phenotypic flexibility." @default.
- W2791930922 created "2018-03-29" @default.
- W2791930922 creator A5001284138 @default.
- W2791930922 creator A5056088482 @default.
- W2791930922 date "2018-02-21" @default.
- W2791930922 modified "2023-10-18" @default.
- W2791930922 title "Emergent buffering balances evolvability and robustness in the evolution of phenotypic flexibility" @default.
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- W2791930922 doi "https://doi.org/10.1111/evo.13441" @default.
- W2791930922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29380879" @default.
- W2791930922 hasPublicationYear "2018" @default.
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