FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2791932949> ?p ?o ?g. }

• W2791932949 endingPage "165" @default.
• W2791932949 startingPage "158" @default.
• W2791932949 abstract "Daptomycin has shown activity against a wide range of Gram-positive bacteria; however, the approved dosages usually seem insufficient for critically ill patients. The aim of this study was to develop a population pharmacokinetic model for daptomycin in critically ill patients and to estimate the success of the therapy by applying pharmacokinetic/pharmacodynamic (PK/PD) criteria. Sixteen intensive care unit patients were included, four of whom underwent continuous renal replacement therapies (CRRT). Blood and, when necessary, effluent samples were drawn after daptomycin administration at previously defined time points. A population approach using NONMEM 7.3 was performed to analyse data. Monte Carlo simulations were executed to evaluate the suitability of different dosage regimens. The probabilities of achieving the PK/PD target value associated with treatment success (ratio of the area under the plasma concentration-time curve over 24 h divided by the minimum inhibitory concentration (AUC24/MIC ≥ 666)) and to reach daptomycin concentrations linked to toxicity (minimum concentration at steady-state (Cminss) ≥ 24.3 mg/L) were calculated. The pharmacokinetics of daptomycin was best described by a one-compartment model. Elimination was conditioned by the creatinine clearance (Clcr) and also by the extra-corporeal clearance when patients were subjected to continuous renal replacement therapy (CRRT). The PK/PD analysis confirmed that 280- and 420-mg/d dosages would not be enough to achieve high probabilities of target attainment for MIC values ≥ 1 mg/L in patients with Clcr ≥ 60 mL/min or in subjects with lower Clcrs but receiving CRRT. In these patients, higher dosages (560–840 mg/d) should be needed. When treating infections due to MIC values ≥ 4 mg/L, even the highest dose would be insufficient." @default.
• W2791932949 created "2018-03-29" @default.
• W2791932949 creator A5007573955 @default.
• W2791932949 creator A5014139370 @default.
• W2791932949 creator A5015256484 @default.
• W2791932949 creator A5037711682 @default.
• W2791932949 creator A5058499540 @default.
• W2791932949 creator A5061802598 @default.
• W2791932949 creator A5065938149 @default.
• W2791932949 creator A5087025167 @default.
• W2791932949 date "2018-08-01" @default.
• W2791932949 modified "2023-10-16" @default.
• W2791932949 title "Population pharmacokinetics of daptomycin in critically ill patients" @default.
• W2791932949 cites W1608647205 @default.
• W2791932949 cites W1967547929 @default.
• W2791932949 cites W1974903759 @default.
• W2791932949 cites W1983960319 @default.
• W2791932949 cites W1993287556 @default.
• W2791932949 cites W1997261364 @default.
• W2791932949 cites W2039915339 @default.
• W2791932949 cites W2048290541 @default.
• W2791932949 cites W2066464642 @default.
• W2791932949 cites W2087478209 @default.
• W2791932949 cites W2093073135 @default.
• W2791932949 cites W2096225844 @default.
• W2791932949 cites W2101835294 @default.
• W2791932949 cites W2107005334 @default.
• W2791932949 cites W2108433768 @default.
• W2791932949 cites W2109487334 @default.
• W2791932949 cites W2115215601 @default.
• W2791932949 cites W2116089057 @default.
• W2791932949 cites W2125725269 @default.
• W2791932949 cites W2130500792 @default.
• W2791932949 cites W2137521215 @default.
• W2791932949 cites W2145284269 @default.
• W2791932949 cites W2146175354 @default.
• W2791932949 cites W2147918946 @default.
• W2791932949 cites W2151547308 @default.
• W2791932949 cites W2165158988 @default.
• W2791932949 cites W2169170075 @default.
• W2791932949 cites W2178495177 @default.
• W2791932949 cites W2219180212 @default.
• W2791932949 cites W2288142363 @default.
• W2791932949 cites W2297596467 @default.
• W2791932949 doi "https://doi.org/10.1016/j.ijantimicag.2018.03.008" @default.
• W2791932949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29572042" @default.
• W2791932949 hasPublicationYear "2018" @default.
• W2791932949 type Work @default.
• W2791932949 sameAs 2791932949 @default.
• W2791932949 citedByCount "28" @default.
• W2791932949 countsByYear W27919329492019 @default.
• W2791932949 countsByYear W27919329492020 @default.
• W2791932949 countsByYear W27919329492021 @default.
• W2791932949 countsByYear W27919329492022 @default.
• W2791932949 countsByYear W27919329492023 @default.
• W2791932949 crossrefType "journal-article" @default.
• W2791932949 hasAuthorship W2791932949A5007573955 @default.
• W2791932949 hasAuthorship W2791932949A5014139370 @default.
• W2791932949 hasAuthorship W2791932949A5015256484 @default.
• W2791932949 hasAuthorship W2791932949A5037711682 @default.
• W2791932949 hasAuthorship W2791932949A5058499540 @default.
• W2791932949 hasAuthorship W2791932949A5061802598 @default.
• W2791932949 hasAuthorship W2791932949A5065938149 @default.
• W2791932949 hasAuthorship W2791932949A5087025167 @default.
• W2791932949 hasConcept C111113717 @default.
• W2791932949 hasConcept C112705442 @default.
• W2791932949 hasConcept C126322002 @default.
• W2791932949 hasConcept C159641895 @default.
• W2791932949 hasConcept C162156334 @default.
• W2791932949 hasConcept C2776239304 @default.
• W2791932949 hasConcept C2776376669 @default.
• W2791932949 hasConcept C2778651397 @default.
• W2791932949 hasConcept C2778980435 @default.
• W2791932949 hasConcept C2779489039 @default.
• W2791932949 hasConcept C2779541074 @default.
• W2791932949 hasConcept C2780272996 @default.
• W2791932949 hasConcept C2908647359 @default.
• W2791932949 hasConcept C2991859549 @default.
• W2791932949 hasConcept C523546767 @default.
• W2791932949 hasConcept C54355233 @default.
• W2791932949 hasConcept C71924100 @default.
• W2791932949 hasConcept C76318530 @default.
• W2791932949 hasConcept C86803240 @default.
• W2791932949 hasConcept C98274493 @default.
• W2791932949 hasConcept C99454951 @default.
• W2791932949 hasConceptScore W2791932949C111113717 @default.
• W2791932949 hasConceptScore W2791932949C112705442 @default.
• W2791932949 hasConceptScore W2791932949C126322002 @default.
• W2791932949 hasConceptScore W2791932949C159641895 @default.
• W2791932949 hasConceptScore W2791932949C162156334 @default.
• W2791932949 hasConceptScore W2791932949C2776239304 @default.
• W2791932949 hasConceptScore W2791932949C2776376669 @default.
• W2791932949 hasConceptScore W2791932949C2778651397 @default.
• W2791932949 hasConceptScore W2791932949C2778980435 @default.
• W2791932949 hasConceptScore W2791932949C2779489039 @default.
• W2791932949 hasConceptScore W2791932949C2779541074 @default.
• W2791932949 hasConceptScore W2791932949C2780272996 @default.
• W2791932949 hasConceptScore W2791932949C2908647359 @default.

• next