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- W2792016711 abstract "Allergic asthma is a complex inflammatory disease that leads to significant healthcare costs and reduction in quality of life. Although many cell types are implicated in the pathogenesis of asthma, CD4+ T-helper cell type 2 (Th2) cells are centrally involved. We previously reported that the asthma phenotype is virtually absent in ovalbumin-sensitized and -challenged mice that lack global expression of β-arrestin (β-arr)-2 and that CD4+ T cells from these mice displayed significantly reduced CCL22-mediated chemotaxis. Because CCL22-mediated activation of CCR4 plays a role in Th2 cell regulation in asthmatic inflammation, we hypothesized that CCR4-mediated migration of CD4+ Th2 cells to the lung in asthma may use β-arr-dependent signaling. To test this hypothesis, we assessed the effect of various signaling inhibitors on CCL22-induced chemotaxis using in vitro-polarized primary CD4+ Th2 cells from β-arr2-knockout and wild-type mice. Our results show, for the first time, that CCL22-induced, CCR4-mediated Th2 cell chemotaxis is dependent, in part, on a β-arr2-dependent signaling pathway. In addition, we show that this chemotactic signaling mechanism involves activation of P-p38 and Rho-associated protein kinase. These findings point to a proinflammatory role for β-arr2-dependent signaling and support β-arr2 as a novel therapeutic target in asthma." @default.
- W2792016711 created "2018-03-29" @default.
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- W2792016711 date "2018-06-01" @default.
- W2792016711 modified "2023-10-15" @default.
- W2792016711 title "β-Arrestin-2–Dependent Signaling Promotes CCR4–mediated Chemotaxis of Murine T-Helper Type 2 Cells" @default.
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- W2792016711 cites W1979874532 @default.
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- W2792016711 cites W1991725836 @default.
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- W2792016711 cites W1993717649 @default.
- W2792016711 cites W1993937267 @default.
- W2792016711 cites W1994161105 @default.
- W2792016711 cites W1996050448 @default.
- W2792016711 cites W2004408127 @default.
- W2792016711 cites W2015370039 @default.
- W2792016711 cites W2015917620 @default.
- W2792016711 cites W2018779510 @default.
- W2792016711 cites W2024625315 @default.
- W2792016711 cites W2027699993 @default.
- W2792016711 cites W2031501484 @default.
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- W2792016711 doi "https://doi.org/10.1165/rcmb.2017-0240oc" @default.
- W2792016711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6002661" @default.
- W2792016711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29361236" @default.
- W2792016711 hasPublicationYear "2018" @default.
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