FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792023400> ?p ?o ?g. }

• W2792023400 endingPage "3766" @default.
• W2792023400 startingPage "3753" @default.
• W2792023400 abstract "Inhibitory interneurons sculpt the outputs of excitatory circuits to expand the dynamic range of information processing. In mammalian retina, >30 types of amacrine cells provide lateral inhibition to vertical, excitatory bipolar cell circuits, but functional roles for only a few amacrine cells are well established. Here, we elucidate the function of corticotropin-releasing hormone (CRH)-expressing amacrine cells labeled in Cre-transgenic mice of either sex. CRH cells costratify with the ON alpha ganglion cell, a neuron highly sensitive to positive contrast. Electrophysiological and optogenetic analyses demonstrate that two CRH types (CRH-1 and CRH-3) make GABAergic synapses with ON alpha cells. CRH-1 cells signal via graded membrane potential changes, whereas CRH-3 cells fire action potentials. Both types show sustained ON-type responses to positive contrast over a range of stimulus conditions. Optogenetic control of transmission at CRH-1 synapses demonstrates that these synapses are tuned to low temporal frequencies, maintaining GABA release during fast hyperpolarizations during brief periods of negative contrast. CRH amacrine cell output is suppressed by prolonged negative contrast, when ON alpha ganglion cells continue to receive inhibitory input from converging OFF-pathway amacrine cells; the converging ON- and OFF-pathway inhibition balances tonic excitatory drive to ON alpha cells. Previously, it was demonstrated that CRH-1 cells inhibit firing by suppressed-by-contrast (SbC) ganglion cells during positive contrast. Therefore, divergent outputs of CRH-1 cells inhibit two ganglion cell types with opposite responses to positive contrast. The opposing responses of ON alpha and SbC ganglion cells are explained by differing excitation/inhibition balance in the two circuits. SIGNIFICANCE STATEMENT A goal of neuroscience research is to explain the function of neural circuits at the level of specific cell types. Here, we studied the function of specific types of inhibitory interneurons, corticotropin-releasing hormone (CRH) amacrine cells, in the mouse retina. Genetic tools were used to identify and manipulate CRH cells, which make GABAergic synapses with a well studied ganglion cell type, the ON alpha cell. CRH cells converge with other types of amacrine cells to tonically inhibit ON alpha cells and balance their high level of excitation. CRH cells diverge to different types of ganglion cell, the unique properties of which depend on their balance of excitation and inhibition." @default.
• W2792023400 created "2018-03-29" @default.
• W2792023400 creator A5004418040 @default.
• W2792023400 creator A5011748503 @default.
• W2792023400 creator A5012123840 @default.
• W2792023400 creator A5034529301 @default.
• W2792023400 creator A5037894693 @default.
• W2792023400 creator A5066404351 @default.
• W2792023400 creator A5075423711 @default.
• W2792023400 creator A5079924386 @default.
• W2792023400 date "2018-03-23" @default.
• W2792023400 modified "2023-09-30" @default.
• W2792023400 title "Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry" @default.
• W2792023400 cites W1136933746 @default.
• W2792023400 cites W1560950175 @default.
• W2792023400 cites W1568868446 @default.
• W2792023400 cites W1580405273 @default.
• W2792023400 cites W1786098380 @default.
• W2792023400 cites W1829998668 @default.
• W2792023400 cites W1853085112 @default.
• W2792023400 cites W1898957235 @default.
• W2792023400 cites W1964031992 @default.
• W2792023400 cites W1984390450 @default.
• W2792023400 cites W1984579614 @default.
• W2792023400 cites W1984644816 @default.
• W2792023400 cites W1986209073 @default.
• W2792023400 cites W1990779469 @default.
• W2792023400 cites W1991302410 @default.
• W2792023400 cites W1992618284 @default.
• W2792023400 cites W1992790774 @default.
• W2792023400 cites W1995043049 @default.
• W2792023400 cites W2008624261 @default.
• W2792023400 cites W2009477947 @default.
• W2792023400 cites W2016873833 @default.
• W2792023400 cites W2020310113 @default.
• W2792023400 cites W2031675933 @default.
• W2792023400 cites W2032633728 @default.
• W2792023400 cites W2034893938 @default.
• W2792023400 cites W2036239753 @default.
• W2792023400 cites W2037084455 @default.
• W2792023400 cites W2040574649 @default.
• W2792023400 cites W2043001689 @default.
• W2792023400 cites W2044682466 @default.
• W2792023400 cites W2045353541 @default.
• W2792023400 cites W2047141148 @default.
• W2792023400 cites W2051185231 @default.
• W2792023400 cites W2053013902 @default.
• W2792023400 cites W2058727942 @default.
• W2792023400 cites W2064094924 @default.
• W2792023400 cites W2064449994 @default.
• W2792023400 cites W2067328729 @default.
• W2792023400 cites W2067501282 @default.
• W2792023400 cites W2072060769 @default.
• W2792023400 cites W2077105925 @default.
• W2792023400 cites W2077229035 @default.
• W2792023400 cites W2078952905 @default.
• W2792023400 cites W2080028242 @default.
• W2792023400 cites W2081066886 @default.
• W2792023400 cites W2082861955 @default.
• W2792023400 cites W2089205664 @default.
• W2792023400 cites W2090651497 @default.
• W2792023400 cites W2100697401 @default.
• W2792023400 cites W2102269654 @default.
• W2792023400 cites W2102913975 @default.
• W2792023400 cites W2104135721 @default.
• W2792023400 cites W2106700142 @default.
• W2792023400 cites W2115135943 @default.
• W2792023400 cites W2115441910 @default.
• W2792023400 cites W2115734536 @default.
• W2792023400 cites W2120428149 @default.
• W2792023400 cites W2121071682 @default.
• W2792023400 cites W2121289914 @default.
• W2792023400 cites W2125277430 @default.
• W2792023400 cites W2135911939 @default.
• W2792023400 cites W2149208048 @default.
• W2792023400 cites W2150413435 @default.
• W2792023400 cites W2154082572 @default.
• W2792023400 cites W2164414836 @default.
• W2792023400 cites W2166357227 @default.
• W2792023400 cites W2166414874 @default.
• W2792023400 cites W2170749456 @default.
• W2792023400 cites W2171946863 @default.
• W2792023400 cites W2174781702 @default.
• W2792023400 cites W2203701388 @default.
• W2792023400 cites W2313348546 @default.
• W2792023400 cites W2329913331 @default.
• W2792023400 cites W2336052402 @default.
• W2792023400 cites W2346901928 @default.
• W2792023400 cites W2510746232 @default.
• W2792023400 cites W2586433236 @default.
• W2792023400 cites W2609509183 @default.
• W2792023400 cites W2618821020 @default.
• W2792023400 cites W2741756578 @default.
• W2792023400 cites W2753853310 @default.
• W2792023400 cites W343646019 @default.
• W2792023400 cites W4296436262 @default.
• W2792023400 cites W4301042878 @default.
• W2792023400 doi "https://doi.org/10.1523/jneurosci.2518-17.2018" @default.

• next