FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792034293> ?p ?o ?g. }

• W2792034293 endingPage "1471" @default.
• W2792034293 startingPage "1455" @default.
• W2792034293 abstract "Background/Aims: Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years and has accumulated considerable knowledge concerning the in vivo efficacy of targeting complicated diseases. TCM formulae are a mixture of hundreds of chemical components with multiple potential targets, essentially acting as a combination therapy of multi-component drugs. However, the obscure substances and the unclear molecular mechanisms are obstacles to their further development and internationalization. Therefore, it is necessary to develop new modern drugs based on the combination of effective components in TCM with exact clinical efficacy. In present study, we aimed to detect optimal ratio of the combination of effective components based on Sheng-Mai-San for myocardial ischemia. Methods: On the basis of preliminary studies and references of relevant literature about Sheng-Mai-San for myocardial ischemia, we chose three representative components (ginsenoside Rb1 (G), ruscogenin (R) and schisandrin (S)) for the optimization design studies. First, the proper proportion of the combination was explored in different myocardial ischemia mice induced by isoproterenol and pituitrin based on orthogonal design. Then, the different proportion combinations were further optimized through uniform design in a multi-model and multi-index mode. Finally, the protective effect of combination was verified in three models of myocardial ischemia injured by ischemia/reperfusion, chronic intermittent hypoxia and acute infarction. Results: The optimized combination GRS (G: 6 mg/kg, R: 0.75 mg/kg, S: 6 mg/kg) obtained by experimental screening exhibited a significant protective effect on myocardial ischemia injury, as evidenced by decreased myocardium infarct size, ameliorated histological features, decreased myocardial myeloperoxidase (MPO) and malondiadehyde (MDA), calcium overload, and decreased serum lactate dehydrogenase (LDH), creatine kinase MB isoenzyme (CK-MB), cardiac troponin I (cTn-I) activity. In addition, the interactions of three components in combination GRS were also investigated. The combination, compared to G, R and S, could significantly reduce the concentration of serum CK-MB and cTn-I, and decrease myocardial infarct size, which demonstrated the advantages of this combination for myocardial ischemia. Conclusion: Our results demonstrated that the optimized combination GRS could exert significant cardioprotection against myocardial ischemia injury with similar effect compared to Sheng Mai preparations, which might provide some pharmacological evidences for further development of new modern Chinese drug for cardiovascular diseases basing on traditional Chinese formula with affirmative therapeutic effect." @default.
• W2792034293 created "2018-03-29" @default.
• W2792034293 creator A5008666774 @default.
• W2792034293 creator A5018831670 @default.
• W2792034293 creator A5020248771 @default.
• W2792034293 creator A5032289249 @default.
• W2792034293 creator A5038602630 @default.
• W2792034293 creator A5054308759 @default.
• W2792034293 date "2018-01-01" @default.
• W2792034293 modified "2023-10-16" @default.
• W2792034293 title "A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia" @default.
• W2792034293 cites W1970625672 @default.
• W2792034293 cites W1971746603 @default.
• W2792034293 cites W1975404751 @default.
• W2792034293 cites W1991448604 @default.
• W2792034293 cites W2000262165 @default.
• W2792034293 cites W2010120511 @default.
• W2792034293 cites W2010217891 @default.
• W2792034293 cites W2019922945 @default.
• W2792034293 cites W2041699905 @default.
• W2792034293 cites W2042767959 @default.
• W2792034293 cites W2043355876 @default.
• W2792034293 cites W2047191463 @default.
• W2792034293 cites W2063906445 @default.
• W2792034293 cites W2065812641 @default.
• W2792034293 cites W2067878995 @default.
• W2792034293 cites W2068625657 @default.
• W2792034293 cites W2071479387 @default.
• W2792034293 cites W2080878805 @default.
• W2792034293 cites W2095069908 @default.
• W2792034293 cites W2096990253 @default.
• W2792034293 cites W2114925082 @default.
• W2792034293 cites W2134794720 @default.
• W2792034293 cites W2134967712 @default.
• W2792034293 cites W2146907709 @default.
• W2792034293 cites W2349762938 @default.
• W2792034293 cites W2359050820 @default.
• W2792034293 cites W2364907359 @default.
• W2792034293 cites W2375341413 @default.
• W2792034293 cites W2389197420 @default.
• W2792034293 cites W2473305081 @default.
• W2792034293 cites W2551429873 @default.
• W2792034293 cites W2557701040 @default.
• W2792034293 cites W275521517 @default.
• W2792034293 cites W2793851406 @default.
• W2792034293 doi "https://doi.org/10.1159/000487572" @default.
• W2792034293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29466787" @default.
• W2792034293 hasPublicationYear "2018" @default.
• W2792034293 type Work @default.
• W2792034293 sameAs 2792034293 @default.
• W2792034293 citedByCount "25" @default.
• W2792034293 countsByYear W27920342932019 @default.
• W2792034293 countsByYear W27920342932020 @default.
• W2792034293 countsByYear W27920342932021 @default.
• W2792034293 countsByYear W27920342932022 @default.
• W2792034293 countsByYear W27920342932023 @default.
• W2792034293 crossrefType "journal-article" @default.
• W2792034293 hasAuthorship W2792034293A5008666774 @default.
• W2792034293 hasAuthorship W2792034293A5018831670 @default.
• W2792034293 hasAuthorship W2792034293A5020248771 @default.
• W2792034293 hasAuthorship W2792034293A5032289249 @default.
• W2792034293 hasAuthorship W2792034293A5038602630 @default.
• W2792034293 hasAuthorship W2792034293A5054308759 @default.
• W2792034293 hasBestOaLocation W27920342931 @default.
• W2792034293 hasConcept C142724271 @default.
• W2792034293 hasConcept C150903083 @default.
• W2792034293 hasConcept C164705383 @default.
• W2792034293 hasConcept C188947578 @default.
• W2792034293 hasConcept C204787440 @default.
• W2792034293 hasConcept C207001950 @default.
• W2792034293 hasConcept C2776999253 @default.
• W2792034293 hasConcept C2779676291 @default.
• W2792034293 hasConcept C3017461755 @default.
• W2792034293 hasConcept C500558357 @default.
• W2792034293 hasConcept C541997718 @default.
• W2792034293 hasConcept C71924100 @default.
• W2792034293 hasConcept C86803240 @default.
• W2792034293 hasConcept C98274493 @default.
• W2792034293 hasConceptScore W2792034293C142724271 @default.
• W2792034293 hasConceptScore W2792034293C150903083 @default.
• W2792034293 hasConceptScore W2792034293C164705383 @default.
• W2792034293 hasConceptScore W2792034293C188947578 @default.
• W2792034293 hasConceptScore W2792034293C204787440 @default.
• W2792034293 hasConceptScore W2792034293C207001950 @default.
• W2792034293 hasConceptScore W2792034293C2776999253 @default.
• W2792034293 hasConceptScore W2792034293C2779676291 @default.
• W2792034293 hasConceptScore W2792034293C3017461755 @default.
• W2792034293 hasConceptScore W2792034293C500558357 @default.
• W2792034293 hasConceptScore W2792034293C541997718 @default.
• W2792034293 hasConceptScore W2792034293C71924100 @default.
• W2792034293 hasConceptScore W2792034293C86803240 @default.
• W2792034293 hasConceptScore W2792034293C98274493 @default.
• W2792034293 hasIssue "4" @default.
• W2792034293 hasLocation W27920342931 @default.
• W2792034293 hasLocation W27920342932 @default.
• W2792034293 hasLocation W27920342933 @default.
• W2792034293 hasOpenAccess W2792034293 @default.
• W2792034293 hasPrimaryLocation W27920342931 @default.

• next