FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792052564> ?p ?o ?g. }

• W2792052564 endingPage "158" @default.
• W2792052564 startingPage "149" @default.
• W2792052564 abstract "Understanding the neurobiological mechanisms underlying the response to an acute stressor may provide novel insights into successful stress-coping strategies. Acute behavioral stress-effects may be restricted to a specific time window early after stress-induction. However, existing behavioral test batteries typically span multiple days or even weeks, limiting the feasibility for a broad behavioral analysis following acute stress. Here, we designed a novel comprehensive behavioral test battery in male mice that assesses multiple behavioral dimensions within a sufficiently brief time window to capture acute stress-effects and its temporal profile. Using this battery, we investigated the behavioral impact of acute social defeat stress (ASD) early thereafter (ASD-early, ∼4 h), when circulating corticosterone levels were elevated, and late after stress-induction (ASD-late, ∼8 h), when corticosterone were returned to timed control levels. ASD-early, but not ASD-late, displayed hippocampal-dependent cognitive impairments in the Y-maze and in the spatial object recognition test. The actin-binding protein (ABP) Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) has been described as resilience-promoting factor but the potential of DRR1 to curb stress-effects has not been investigated. Hippocampal DRR1 mRNA-expression was increased in ASD-early and ASD-late whereas DRR1-protein levels were increased only in ASD-late. We hypothesized that the absence of hippocampal DRR1 protein-upregulation in ASD-early caused the associated cognitive impairments. Hence, virus-mediated hippocampal DRR1-overexpression was induced as putative treatment, but cognitive deficits in ASD-early were not improved. We conclude that hippocampal DRR1-overexpression is insufficient to protect from the detrimental cognitive effects following acute social stress where perhaps a more global response in local actin dynamics, involving multiple stress-responsive ABPs that act synergistically, was warranted." @default.
• W2792052564 created "2018-03-29" @default.
• W2792052564 creator A5003243052 @default.
• W2792052564 creator A5006911509 @default.
• W2792052564 creator A5021787400 @default.
• W2792052564 creator A5026407953 @default.
• W2792052564 creator A5030860744 @default.
• W2792052564 creator A5073529348 @default.
• W2792052564 date "2018-05-01" @default.
• W2792052564 modified "2023-10-01" @default.
• W2792052564 title "Temporal profiling of an acute stress-induced behavioral phenotype in mice and role of hippocampal DRR1" @default.
• W2792052564 cites W1920988707 @default.
• W2792052564 cites W1965301255 @default.
• W2792052564 cites W1967764121 @default.
• W2792052564 cites W1967988059 @default.
• W2792052564 cites W1974054391 @default.
• W2792052564 cites W1975040096 @default.
• W2792052564 cites W1977593923 @default.
• W2792052564 cites W1980944036 @default.
• W2792052564 cites W1981654563 @default.
• W2792052564 cites W1986782185 @default.
• W2792052564 cites W1986886791 @default.
• W2792052564 cites W1987375729 @default.
• W2792052564 cites W1992523889 @default.
• W2792052564 cites W1993930759 @default.
• W2792052564 cites W1996563049 @default.
• W2792052564 cites W1997263445 @default.
• W2792052564 cites W1998829655 @default.
• W2792052564 cites W2002802459 @default.
• W2792052564 cites W2003340810 @default.
• W2792052564 cites W2007012468 @default.
• W2792052564 cites W2010727732 @default.
• W2792052564 cites W2018643157 @default.
• W2792052564 cites W2019873066 @default.
• W2792052564 cites W2021700795 @default.
• W2792052564 cites W2021703037 @default.
• W2792052564 cites W2024032885 @default.
• W2792052564 cites W2024493419 @default.
• W2792052564 cites W2029505958 @default.
• W2792052564 cites W2030933765 @default.
• W2792052564 cites W2032923343 @default.
• W2792052564 cites W2037973854 @default.
• W2792052564 cites W2047810860 @default.
• W2792052564 cites W2049191904 @default.
• W2792052564 cites W2052390712 @default.
• W2792052564 cites W2053660665 @default.
• W2792052564 cites W2053862541 @default.
• W2792052564 cites W2064910482 @default.
• W2792052564 cites W2065341809 @default.
• W2792052564 cites W2065847146 @default.
• W2792052564 cites W2066184233 @default.
• W2792052564 cites W2066680913 @default.
• W2792052564 cites W2066838264 @default.
• W2792052564 cites W2077819377 @default.
• W2792052564 cites W2078385314 @default.
• W2792052564 cites W2093937755 @default.
• W2792052564 cites W2094978561 @default.
• W2792052564 cites W2109091674 @default.
• W2792052564 cites W2112132609 @default.
• W2792052564 cites W2112280040 @default.
• W2792052564 cites W2114129553 @default.
• W2792052564 cites W2132695255 @default.
• W2792052564 cites W2147602589 @default.
• W2792052564 cites W2154640125 @default.
• W2792052564 cites W2162743207 @default.
• W2792052564 cites W2170374268 @default.
• W2792052564 cites W2175484872 @default.
• W2792052564 cites W2218866964 @default.
• W2792052564 cites W23041829 @default.
• W2792052564 cites W2313174180 @default.
• W2792052564 cites W2426168356 @default.
• W2792052564 cites W2508393743 @default.
• W2792052564 cites W2516100705 @default.
• W2792052564 cites W2547849868 @default.
• W2792052564 cites W4319425380 @default.
• W2792052564 cites W1971717500 @default.
• W2792052564 doi "https://doi.org/10.1016/j.psyneuen.2018.03.004" @default.
• W2792052564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29555365" @default.
• W2792052564 hasPublicationYear "2018" @default.
• W2792052564 type Work @default.
• W2792052564 sameAs 2792052564 @default.
• W2792052564 citedByCount "14" @default.
• W2792052564 countsByYear W27920525642018 @default.
• W2792052564 countsByYear W27920525642020 @default.
• W2792052564 countsByYear W27920525642021 @default.
• W2792052564 countsByYear W27920525642022 @default.
• W2792052564 countsByYear W27920525642023 @default.
• W2792052564 crossrefType "journal-article" @default.
• W2792052564 hasAuthorship W2792052564A5003243052 @default.
• W2792052564 hasAuthorship W2792052564A5006911509 @default.
• W2792052564 hasAuthorship W2792052564A5021787400 @default.
• W2792052564 hasAuthorship W2792052564A5026407953 @default.
• W2792052564 hasAuthorship W2792052564A5030860744 @default.
• W2792052564 hasAuthorship W2792052564A5073529348 @default.
• W2792052564 hasConcept C126322002 @default.
• W2792052564 hasConcept C148762608 @default.
• W2792052564 hasConcept C15744967 @default.
• W2792052564 hasConcept C169760540 @default.

• next