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- W2792078189 abstract "Research on the human gut pathogen Clostridium difficile and its toxins has gained much attention, particularly as a consequence of the increasing threat to human health presented by emerging hypervirulent strains. Toxin A (TcdA) and B (TcdB) are the two major virulence determinants of C. difficile. Both are single-chain proteins with a similar multidomain architecture. Certain hypervirulent C. difficile strains also produce a third toxin, namely binary toxin CDT (Clostridium difficile transferase). As C. difficile toxins are the causative agents of C. difficile-associated diseases (CDAD), such as antibiotics-associated diarrhea and pseudomembranous colitis, considerable efforts have been expended to unravel their molecular mode-of-action and the cellular mechanisms responsible for their uptake. Notably, a high proportion of studies on C. difficile toxins were performed in European laboratories. In this chapter we will highlight important recent advances in C. difficile toxins research." @default.
- W2792078189 created "2018-03-29" @default.
- W2792078189 creator A5017609049 @default.
- W2792078189 creator A5044949409 @default.
- W2792078189 creator A5057837691 @default.
- W2792078189 creator A5072111511 @default.
- W2792078189 date "2018-01-01" @default.
- W2792078189 modified "2023-10-11" @default.
- W2792078189 title "Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins" @default.
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