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• W2792094665 abstract "INTRODUCTION Atherosclerotic vascular diseases, which comprises coronary heart disease and cerebro-vascular disease is a major global health burden. They constitute 21.9 per cent of total deaths globally and are projected to increase further to 26.3 per cent by 2030. The prevalence of diabetes is a global health burden. The overall prevalence is expected to rise from 285 million in 2010 to 438 million by the year 2030. While diabetes poses a huge economic burden to all nations, developing countries bear the highest burden since more than 80% of cases occur in these countries. Diabetes is considered as an independent risk factor for coronary artery disease and cardio vascular diseases. As per NCEP ATP III guidelines, diabetes is considered as a coronary artery disease equivalent. Diabetes affects the endothelium and the glycation products get denatured and accelerate the process of atherosclerosis. Diabetic patients when compared to non-diabetics have increased risk of developing vascular complications and have two to four fold risk of developing coronary artery disease (CAD). They are more likely to develop vascular complications, affecting all the major organs of body. Cardiovascular diseases constitute one of the major cause of mortality and morbidity in diabetics, accounting for nearly 65-75% of deaths. The results of Framingham study reveals a 2 fold risk of cardiovascular death in men and 4-5 fold risk of cardiovascular death in women with diabetes. They constitute the major cause of death in adult diabetic patients. Diabetics are likely to have low HDL levels than people without DM. Low HDL levels have been strongly associated with elevated risk for CAD. AIM OF THE STUDY : Primary Aim : 1. To assess the severity of CAD by coronary angiography in pre-diabetic, diabetic and non-diabetic patients presenting with acute coronary syndrome 2. To assess the correlation between glycemic control and severity of CAD. Secondary Aim : 1. To assess the relationship between the duration of diabetes and severity of CAD in diabetic patients CONCLUSION : 1. A total of 412 patients were studied, of which majority of the patients were diabetics (51.7%) 2. Male predominance was noted in all the study groups 3. Mean Age of presentation was 56.3± 10.2 among diabetics, 54.5 ±12.2 among non-diabetics and 54.4± 9.3 among pre-diabetics. There was no much difference in mean age of presentation among study groups. Patients with age range between 46-60 years were commonly affected in all the study groups. 4. Chest pain and sweating were the common presenting symptom in all groups 5. STEMI was comparatively higher in non-diabetics. However this was statistically insignificant. 6. Hypertension was more among diabetics, whereas obesity was higher in both Pre-diabetics and diabetics. 7. Diabetics had more prevalence of Low HDL. 9% and 6 % of Pre-diabetics and diabetics had very high LDL levels respectively. 8. Diabetics had more severe CAD with a gensini score of 47.1 ±31.1, followed by Pre-diabetics with a gensini score of 41.5±25.1. Non-Diabetics had comparatively less severe CAD with a gensini score of 38.45±33.9. 9. Single vessel disease was more in pre-diabetics and non-diabetics. Whereas diabetics had more triple vessel disease. 10. There was no significant difference in the severity of CAD among Pre-diabetic patients with IFG alone, IGT alone and combined IFG and IGT. 11. Patients with diabetes had a significant positive linear correlation between duration of diabetes and severity of CAD. 12. There was no statistically significant correlation between HbA1c levels and severity of CAD in diabetics. 13. Presenting blood sugar levels was found to have significant positive linear correlation with severity of CAD in all the three groups. This finding was more consistent in pre-diabetic patients." @default.
• W2792094665 created "2018-03-29" @default.
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• W2792094665 date "2013-08-01" @default.
• W2792094665 modified "2023-09-27" @default.
• W2792094665 title "Angiographic severity of CAD in patients with Acute Coronary syndrome in correlation to their glycemic status." @default.
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