FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792100086> ?p ?o ?g. }

• W2792100086 endingPage "136" @default.
• W2792100086 startingPage "127" @default.
• W2792100086 abstract "The growing popularity of zebrafish in psychopharmacology and behavioral brain research is partly due to the practicality and simplicity of drug administration in this species. Several drugs may be administered to zebrafish by immersing the fish in the drug solution. Furthermore, numerous drugs developed for mammals, including humans, have been found to show a similar effect profile in the zebrafish. Thus, the zebrafish has been suggested as a potentially useful animal screening tool. Despite decades of drug development, anxiety still represents a major unmet medical need, and the search for anxiolytic compounds is continuing. The zebrafish has been proposed for high throughput screens for anxiolytic compounds, and the effects of anxiolytic compounds on the behavior of zebrafish have started to be explored. Diazepam (Valium®) is a frequently prescribed human anxiolytic, a GABAA receptor agonist, has also started to be tested in zebrafish, but with occasional contradicting results. Here, we investigate the effects of diazepam in larval (6-day post-fertilization old) zebrafish in a black-white preference paradigm. We found significant white preference and thigmotaxis (edge preference) in our control fish, anxiety-like responses that habituated over time. However, unexpectedly, we observed no anxiolytic effects of diazepam on these behaviors, and only detected significant motor activity reducing effect of the drug. We discuss the complex interpretation of light/dark tests in zebrafish, and also speculate about the possibility of differential GABAergic mechanisms that diazepam affects in larval vs adult zebrafish." @default.
• W2792100086 created "2018-03-29" @default.
• W2792100086 creator A5025044762 @default.
• W2792100086 creator A5027783386 @default.
• W2792100086 creator A5040410273 @default.
• W2792100086 creator A5068697469 @default.
• W2792100086 creator A5075288432 @default.
• W2792100086 creator A5082428614 @default.
• W2792100086 date "2018-04-01" @default.
• W2792100086 modified "2023-09-30" @default.
• W2792100086 title "Diazepam fails to alter anxiety-like responses but affects motor function in a white-black test paradigm in larval zebrafish ( Danio rerio )" @default.
• W2792100086 cites W1229456487 @default.
• W2792100086 cites W1500590082 @default.
• W2792100086 cites W1531503374 @default.
• W2792100086 cites W1705218924 @default.
• W2792100086 cites W1965635919 @default.
• W2792100086 cites W1967528036 @default.
• W2792100086 cites W1969683921 @default.
• W2792100086 cites W1972476800 @default.
• W2792100086 cites W1976887222 @default.
• W2792100086 cites W1977629253 @default.
• W2792100086 cites W1981239255 @default.
• W2792100086 cites W1984123159 @default.
• W2792100086 cites W1999317651 @default.
• W2792100086 cites W2001248841 @default.
• W2792100086 cites W2003896813 @default.
• W2792100086 cites W2007564398 @default.
• W2792100086 cites W2010526028 @default.
• W2792100086 cites W2012226634 @default.
• W2792100086 cites W2014275388 @default.
• W2792100086 cites W2016056074 @default.
• W2792100086 cites W2016741477 @default.
• W2792100086 cites W2030169264 @default.
• W2792100086 cites W2034684273 @default.
• W2792100086 cites W2041561931 @default.
• W2792100086 cites W2043336959 @default.
• W2792100086 cites W2047903303 @default.
• W2792100086 cites W2048346982 @default.
• W2792100086 cites W2057462189 @default.
• W2792100086 cites W2063337445 @default.
• W2792100086 cites W2065337015 @default.
• W2792100086 cites W2068621888 @default.
• W2792100086 cites W2073028926 @default.
• W2792100086 cites W2078632142 @default.
• W2792100086 cites W2078832578 @default.
• W2792100086 cites W2079714688 @default.
• W2792100086 cites W2083859487 @default.
• W2792100086 cites W2084054281 @default.
• W2792100086 cites W2088835917 @default.
• W2792100086 cites W2105356326 @default.
• W2792100086 cites W2106366339 @default.
• W2792100086 cites W2107618173 @default.
• W2792100086 cites W2129874579 @default.
• W2792100086 cites W2144838452 @default.
• W2792100086 cites W2156186235 @default.
• W2792100086 cites W2159898375 @default.
• W2792100086 cites W2186791365 @default.
• W2792100086 cites W2188991293 @default.
• W2792100086 cites W2291712389 @default.
• W2792100086 cites W2292985838 @default.
• W2792100086 cites W2316111189 @default.
• W2792100086 cites W2318244874 @default.
• W2792100086 cites W2424111344 @default.
• W2792100086 cites W2514529267 @default.
• W2792100086 cites W2514902469 @default.
• W2792100086 cites W2566999437 @default.
• W2792100086 cites W2597829822 @default.
• W2792100086 cites W2793899761 @default.
• W2792100086 doi "https://doi.org/10.1016/j.pnpbp.2018.01.012" @default.
• W2792100086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29360490" @default.
• W2792100086 hasPublicationYear "2018" @default.
• W2792100086 type Work @default.
• W2792100086 sameAs 2792100086 @default.
• W2792100086 citedByCount "14" @default.
• W2792100086 countsByYear W27921000862019 @default.
• W2792100086 countsByYear W27921000862020 @default.
• W2792100086 countsByYear W27921000862021 @default.
• W2792100086 countsByYear W27921000862022 @default.
• W2792100086 countsByYear W27921000862023 @default.
• W2792100086 crossrefType "journal-article" @default.
• W2792100086 hasAuthorship W2792100086A5025044762 @default.
• W2792100086 hasAuthorship W2792100086A5027783386 @default.
• W2792100086 hasAuthorship W2792100086A5040410273 @default.
• W2792100086 hasAuthorship W2792100086A5068697469 @default.
• W2792100086 hasAuthorship W2792100086A5075288432 @default.
• W2792100086 hasAuthorship W2792100086A5082428614 @default.
• W2792100086 hasConcept C104317684 @default.
• W2792100086 hasConcept C118552586 @default.
• W2792100086 hasConcept C134018914 @default.
• W2792100086 hasConcept C15744967 @default.
• W2792100086 hasConcept C168258287 @default.
• W2792100086 hasConcept C169760540 @default.
• W2792100086 hasConcept C170493617 @default.
• W2792100086 hasConcept C2776175493 @default.
• W2792100086 hasConcept C2776878037 @default.
• W2792100086 hasConcept C2777765862 @default.
• W2792100086 hasConcept C2778173252 @default.
• W2792100086 hasConcept C2779085643 @default.

• next