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- W2792122187 abstract "Cancer is frequently characterised by dysregulation of the cellular signalling processes that govern proliferation, survival and attachment. Understanding such dysregulation continues to present a challenge given the importance of protein-protein interactions in intracellular processes. Exploring this protein-protein interactome requires novel tools capable of discriminating between highly homologous proteins, individual domains and post-translational modifications. This review examines the potential of scaffold-based binding proteins to fulfil these requirements. It also explores protein-protein interactions in the context of intracellular signalling pathways and cancer, and demonstrates the uses of scaffold proteins as functional moderators, biosensors and imaging reagents. This review also highlights the timeliness and potential to develop international consortia to develop and validate highly specific “proteome” scaffold-based binding protein reagents with the ultimate aim of developing screening tools for studying the interactome." @default.
- W2792122187 created "2018-03-29" @default.
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- W2792122187 date "2018-10-01" @default.
- W2792122187 modified "2023-10-14" @default.
- W2792122187 title "Non-immunoglobulin scaffold proteins: Precision tools for studying protein-protein interactions in cancer" @default.
- W2792122187 cites W1461624625 @default.
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- W2792122187 cites W1572174728 @default.
- W2792122187 cites W1589166971 @default.
- W2792122187 cites W1971579914 @default.
- W2792122187 cites W1976101812 @default.
- W2792122187 cites W1976937534 @default.
- W2792122187 cites W1977455794 @default.
- W2792122187 cites W1980877624 @default.
- W2792122187 cites W1981711832 @default.
- W2792122187 cites W1982254984 @default.
- W2792122187 cites W1984161641 @default.
- W2792122187 cites W1990575572 @default.
- W2792122187 cites W1990915902 @default.
- W2792122187 cites W1992831404 @default.
- W2792122187 cites W1995565650 @default.
- W2792122187 cites W2011055713 @default.
- W2792122187 cites W2013757949 @default.
- W2792122187 cites W2023170820 @default.
- W2792122187 cites W2024368008 @default.
- W2792122187 cites W2027988262 @default.
- W2792122187 cites W2033447440 @default.
- W2792122187 cites W2041755933 @default.
- W2792122187 cites W2041935553 @default.
- W2792122187 cites W2048454522 @default.
- W2792122187 cites W2051287873 @default.
- W2792122187 cites W2059958613 @default.
- W2792122187 cites W2061918668 @default.
- W2792122187 cites W2062289724 @default.
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- W2792122187 cites W2077787026 @default.
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- W2792122187 cites W2081990599 @default.
- W2792122187 cites W2088658316 @default.
- W2792122187 cites W2089180620 @default.
- W2792122187 cites W2092114953 @default.
- W2792122187 cites W2102513863 @default.
- W2792122187 cites W2106876831 @default.
- W2792122187 cites W2107972068 @default.
- W2792122187 cites W2109964251 @default.
- W2792122187 cites W2111481626 @default.
- W2792122187 cites W2117692326 @default.
- W2792122187 cites W2121358045 @default.
- W2792122187 cites W2123812453 @default.
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- W2792122187 cites W2144082239 @default.
- W2792122187 cites W2144265524 @default.
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- W2792122187 cites W2149598894 @default.
- W2792122187 cites W2151724015 @default.
- W2792122187 cites W2161298175 @default.
- W2792122187 cites W2165238581 @default.
- W2792122187 cites W2170444099 @default.
- W2792122187 cites W2187458946 @default.
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- W2792122187 cites W2335233385 @default.
- W2792122187 cites W2342374505 @default.
- W2792122187 cites W2343626195 @default.
- W2792122187 cites W2398731353 @default.
- W2792122187 cites W2504365566 @default.
- W2792122187 cites W2548573003 @default.
- W2792122187 cites W2569303361 @default.
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- W2792122187 cites W2739797362 @default.
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- W2792122187 doi "https://doi.org/10.1016/j.nbt.2018.02.008" @default.
- W2792122187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29474834" @default.
- W2792122187 hasPublicationYear "2018" @default.
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