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• W2792127002 abstract "Acid-sensing ion channels (ASICs) are trimeric proton-activated, cation-selective neuronal channels that are considered to play important roles in mechanosensation and nociception. Here we investigated the role of ASIC3, a subunit primarily expressed in sensory neurons, in bladder sensory signaling and function. We found that extracellular acidification evokes a transient increase in current, consistent with the kinetics of activation and desensitization of ASICs, in ~25% of the bladder sensory neurons harvested from both wild-type (WT) and ASIC3 knockout (KO) mice. The absence of ASIC3 increased the magnitude of the peak evoked by extracellular acidification and reduced the rate of decay of the ASIC-like currents. These findings suggest that ASICs are assembled as heteromers and that the absence of ASIC3 alters the composition of these channels in bladder sensory neurons. Consistent with the notion that ASIC3 serves as a proton sensor, 59% of the bladder sensory neurons harvested from WT, but none from ASIC3 KO mice, fired action potentials in response to extracellular acidification. Studies of bladder function revealed that ASIC3 deletion reduces voiding volume and the pressure required to trigger micturition. In summary, our findings indicate that ASIC3 plays a role in the control of bladder function by modulating the response of afferents to filling." @default.
• W2792127002 created "2018-03-29" @default.
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• W2792127002 date "2018-10-01" @default.
• W2792127002 modified "2023-10-18" @default.
• W2792127002 title "ASIC3 fine-tunes bladder sensory signaling" @default.
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• W2792127002 doi "https://doi.org/10.1152/ajprenal.00630.2017" @default.
• W2792127002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6230751" @default.
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