Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792171568> ?p ?o ?g. }
- W2792171568 endingPage "87" @default.
- W2792171568 startingPage "73" @default.
- W2792171568 abstract "The consumption of red meat has been linked to an increased colorectal cancer (CRC) risk. One of the major hypotheses states that heme iron (present in red meat) stimulates the formation of genotoxic N-nitroso compounds (NOCs) and lipid peroxidation products (LPOs). By means of DNA adductomics, chemically induced DNA adduct formation can be mapped in relation to e.g. dietary exposures. In this study, this state-of-the-art methodology was used to investigate alkylation and (lipid per)oxidation induced DNA adduct formation in in vitro red vs. white meat digests. In doing so, 90 alkylation and (lipid per)oxidation induced DNA adduct types could be (tentatively) identified. Overall, 12 NOC- and/or LPO-related DNA adduct types, i.e. dimethyl-T (or ethyl-T), hydroxymethyl-T, tetramethyl-T, methylguanine (MeG), guanidinohydantoin, hydroxybutyl-C, hydroxymethylhydantoin, malondialdehyde-x3-C, O6-carboxymethylguanine, hydroxyethyl-T, carboxyethyl-T and 3,N4-etheno-C were singled out as potential heme-rich meat digestion markers. The retrieval of these DNA adduct markers is in support of the heme, NOC and LPO hypotheses, suggesting that DNA adduct formation may indeed contribute to red meat related CRC risk." @default.
- W2792171568 created "2018-03-29" @default.
- W2792171568 creator A5013261154 @default.
- W2792171568 creator A5031907769 @default.
- W2792171568 creator A5041154105 @default.
- W2792171568 creator A5044418194 @default.
- W2792171568 date "2018-05-01" @default.
- W2792171568 modified "2023-09-30" @default.
- W2792171568 title "DNA adduct profiling of in vitro colonic meat digests to map red vs. white meat genotoxicity" @default.
- W2792171568 cites W1148664835 @default.
- W2792171568 cites W1811102606 @default.
- W2792171568 cites W1963712961 @default.
- W2792171568 cites W1971424572 @default.
- W2792171568 cites W1974576497 @default.
- W2792171568 cites W1975292167 @default.
- W2792171568 cites W1979921579 @default.
- W2792171568 cites W1983439633 @default.
- W2792171568 cites W1994669907 @default.
- W2792171568 cites W1995189040 @default.
- W2792171568 cites W2000833619 @default.
- W2792171568 cites W2003535096 @default.
- W2792171568 cites W2004697593 @default.
- W2792171568 cites W2004718759 @default.
- W2792171568 cites W2008192641 @default.
- W2792171568 cites W2011226144 @default.
- W2792171568 cites W2016004451 @default.
- W2792171568 cites W2016806069 @default.
- W2792171568 cites W2017932539 @default.
- W2792171568 cites W2019017991 @default.
- W2792171568 cites W2027098629 @default.
- W2792171568 cites W2044004589 @default.
- W2792171568 cites W2047766927 @default.
- W2792171568 cites W2061904801 @default.
- W2792171568 cites W2069535648 @default.
- W2792171568 cites W2070888848 @default.
- W2792171568 cites W2074552460 @default.
- W2792171568 cites W2076110072 @default.
- W2792171568 cites W2078770291 @default.
- W2792171568 cites W2079840996 @default.
- W2792171568 cites W2090901001 @default.
- W2792171568 cites W2106489922 @default.
- W2792171568 cites W2108931268 @default.
- W2792171568 cites W2117353547 @default.
- W2792171568 cites W2119694706 @default.
- W2792171568 cites W2121578075 @default.
- W2792171568 cites W2121620432 @default.
- W2792171568 cites W2125628175 @default.
- W2792171568 cites W2128416634 @default.
- W2792171568 cites W2140126848 @default.
- W2792171568 cites W2147669325 @default.
- W2792171568 cites W2147696493 @default.
- W2792171568 cites W2148024341 @default.
- W2792171568 cites W2151989609 @default.
- W2792171568 cites W2156392343 @default.
- W2792171568 cites W2163681189 @default.
- W2792171568 cites W2167590710 @default.
- W2792171568 cites W2171438080 @default.
- W2792171568 cites W2233923246 @default.
- W2792171568 cites W2334337119 @default.
- W2792171568 cites W2464223619 @default.
- W2792171568 cites W2466617793 @default.
- W2792171568 cites W2475192264 @default.
- W2792171568 cites W2528231468 @default.
- W2792171568 cites W2588513928 @default.
- W2792171568 cites W2594113857 @default.
- W2792171568 cites W4245040372 @default.
- W2792171568 cites W4248170525 @default.
- W2792171568 doi "https://doi.org/10.1016/j.fct.2018.02.032" @default.
- W2792171568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29458163" @default.
- W2792171568 hasPublicationYear "2018" @default.
- W2792171568 type Work @default.
- W2792171568 sameAs 2792171568 @default.
- W2792171568 citedByCount "21" @default.
- W2792171568 countsByYear W27921715682018 @default.
- W2792171568 countsByYear W27921715682019 @default.
- W2792171568 countsByYear W27921715682020 @default.
- W2792171568 countsByYear W27921715682021 @default.
- W2792171568 countsByYear W27921715682022 @default.
- W2792171568 countsByYear W27921715682023 @default.
- W2792171568 crossrefType "journal-article" @default.
- W2792171568 hasAuthorship W2792171568A5013261154 @default.
- W2792171568 hasAuthorship W2792171568A5031907769 @default.
- W2792171568 hasAuthorship W2792171568A5041154105 @default.
- W2792171568 hasAuthorship W2792171568A5044418194 @default.
- W2792171568 hasConcept C108204754 @default.
- W2792171568 hasConcept C114246631 @default.
- W2792171568 hasConcept C143425029 @default.
- W2792171568 hasConcept C178790620 @default.
- W2792171568 hasConcept C181199279 @default.
- W2792171568 hasConcept C185592680 @default.
- W2792171568 hasConcept C2776217839 @default.
- W2792171568 hasConcept C2778004101 @default.
- W2792171568 hasConcept C2778089274 @default.
- W2792171568 hasConcept C2778959862 @default.
- W2792171568 hasConcept C2780829032 @default.
- W2792171568 hasConcept C2781247443 @default.
- W2792171568 hasConcept C29730261 @default.
- W2792171568 hasConcept C2994476132 @default.