Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792321835> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2792321835 endingPage "155a" @default.
- W2792321835 startingPage "155a" @default.
- W2792321835 abstract "Interstitial flux of cerebrospinal fluid (CSF) mediates optimal transfer, clearance, and exchange of molecules in the brain. To determine whether disturbances during dehydration or edema lead to neuronal dysfunction, we quantified hydration in the brains of mice subjected to mild water deprivation and measured neuronal excitability in the dehydrated and rehydrated hippocampus. Specifically, we titrated water activity ex vivo using artificial CSF solutions of nonpenetrating inert polymers adjusted to give colloidosmotic pressures in the 0-200 mmHg range. Compared to nondeprived controls, the brains of water-deprived mice had hydration potentials of 94.5 ± 5.4 and 103.8 ± 3.5 mmHg after 12 and 24 hours, respectively, corresponding to 23 and 28 mmHg increases in potential, or 20% and 27% decreases in hydration. The brain-matrix hydraulic conductance, 0.051 ± 0.0019 µl/min/g/mmHg, did not change significantly (n = 6 hydrated/dehydrated pairs). The field excitatory postsynaptic potentials (fEPSP) in the hippocampus, adjusted to hydrations 25 and 125 mmHg below controls, increased 47% and 66%, respectively, but did not change at hydrations up to 75 mmHg above control. In addition, the level of phosphorylated CREB (cAMP response-binding protein), a key mediator of neuronal excitatory pathways, increased in dehydrated hippocampus after subthreshold stimulation.These results show that brain dehydration levels comparable to those measured following short-term water deprivation in mice increase neuronal excitability. Neurons appear very sensitive to water-activity changes, suggesting local dehydration in the interstitial matrix contributes to the cognitive deficits seen in dehydrated humans. As a plausible mechanism, we suggest that lower water activity in dehydrated brains increases the effective concentration of all solutes, modifying the timing, diffusivities, and probabilities of neurotransmitters binding to their cognate receptors." @default.
- W2792321835 created "2018-03-29" @default.
- W2792321835 creator A5021819934 @default.
- W2792321835 creator A5054816466 @default.
- W2792321835 creator A5061642533 @default.
- W2792321835 creator A5075468805 @default.
- W2792321835 creator A5089487611 @default.
- W2792321835 date "2018-02-01" @default.
- W2792321835 modified "2023-09-30" @default.
- W2792321835 title "Brain Interstitial Matrix Hydration Inversely Correlates with Neuronal Excytability" @default.
- W2792321835 doi "https://doi.org/10.1016/j.bpj.2017.11.869" @default.
- W2792321835 hasPublicationYear "2018" @default.
- W2792321835 type Work @default.
- W2792321835 sameAs 2792321835 @default.
- W2792321835 citedByCount "0" @default.
- W2792321835 crossrefType "journal-article" @default.
- W2792321835 hasAuthorship W2792321835A5021819934 @default.
- W2792321835 hasAuthorship W2792321835A5054816466 @default.
- W2792321835 hasAuthorship W2792321835A5061642533 @default.
- W2792321835 hasAuthorship W2792321835A5075468805 @default.
- W2792321835 hasAuthorship W2792321835A5089487611 @default.
- W2792321835 hasBestOaLocation W27923218351 @default.
- W2792321835 hasConcept C112592302 @default.
- W2792321835 hasConcept C12554922 @default.
- W2792321835 hasConcept C126322002 @default.
- W2792321835 hasConcept C134018914 @default.
- W2792321835 hasConcept C148762608 @default.
- W2792321835 hasConcept C15744967 @default.
- W2792321835 hasConcept C169760540 @default.
- W2792321835 hasConcept C170493617 @default.
- W2792321835 hasConcept C185592680 @default.
- W2792321835 hasConcept C2779822359 @default.
- W2792321835 hasConcept C2781161787 @default.
- W2792321835 hasConcept C55493867 @default.
- W2792321835 hasConcept C71924100 @default.
- W2792321835 hasConcept C86803240 @default.
- W2792321835 hasConceptScore W2792321835C112592302 @default.
- W2792321835 hasConceptScore W2792321835C12554922 @default.
- W2792321835 hasConceptScore W2792321835C126322002 @default.
- W2792321835 hasConceptScore W2792321835C134018914 @default.
- W2792321835 hasConceptScore W2792321835C148762608 @default.
- W2792321835 hasConceptScore W2792321835C15744967 @default.
- W2792321835 hasConceptScore W2792321835C169760540 @default.
- W2792321835 hasConceptScore W2792321835C170493617 @default.
- W2792321835 hasConceptScore W2792321835C185592680 @default.
- W2792321835 hasConceptScore W2792321835C2779822359 @default.
- W2792321835 hasConceptScore W2792321835C2781161787 @default.
- W2792321835 hasConceptScore W2792321835C55493867 @default.
- W2792321835 hasConceptScore W2792321835C71924100 @default.
- W2792321835 hasConceptScore W2792321835C86803240 @default.
- W2792321835 hasIssue "3" @default.
- W2792321835 hasLocation W27923218351 @default.
- W2792321835 hasOpenAccess W2792321835 @default.
- W2792321835 hasPrimaryLocation W27923218351 @default.
- W2792321835 hasRelatedWork W185634725 @default.
- W2792321835 hasRelatedWork W1976262441 @default.
- W2792321835 hasRelatedWork W2010108080 @default.
- W2792321835 hasRelatedWork W2051942816 @default.
- W2792321835 hasRelatedWork W2138730144 @default.
- W2792321835 hasRelatedWork W2899285839 @default.
- W2792321835 hasRelatedWork W2993615980 @default.
- W2792321835 hasRelatedWork W3042050588 @default.
- W2792321835 hasRelatedWork W4200451868 @default.
- W2792321835 hasRelatedWork W4323052117 @default.
- W2792321835 hasVolume "114" @default.
- W2792321835 isParatext "false" @default.
- W2792321835 isRetracted "false" @default.
- W2792321835 magId "2792321835" @default.
- W2792321835 workType "article" @default.