Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792342661> ?p ?o ?g. }
- W2792342661 endingPage "1229" @default.
- W2792342661 startingPage "1220" @default.
- W2792342661 abstract "Nuclear factor kappa B ( NF ‐κB) signaling pathway is activated in many colorectal cancer ( CRC ) cells and in the tumor microenvironment, which plays a critical role in cancer initiation, development, and response to therapies. In the present study, we found that the widely used antimalarial drug mefloquine was a NF ‐κB inhibitor that blocked the activation of IκBα kinase, leading to reduction of IκBα degradation, decrease of p65 phosphorylation, and suppressed expression of NF ‐κB target genes in CRC cells. We also found that mefloquine induced growth arrest and apoptosis of CRC cells harboring phosphorylated p65 in culture and in mice. Furthermore, expression of constitutive active IKK β kinase significantly attenuated the cytotoxic effect of the compound. These results showed that mefloquine could exert antitumor action through inhibiting the NF ‐κB signaling pathway, and indicated that the antimalarial drug might be repurposed for anti‐ CRC therapy in the clinic as a single agent or in combination with other anticancer drugs." @default.
- W2792342661 created "2018-03-29" @default.
- W2792342661 creator A5003646610 @default.
- W2792342661 creator A5042241049 @default.
- W2792342661 creator A5050319118 @default.
- W2792342661 creator A5063718631 @default.
- W2792342661 creator A5065753985 @default.
- W2792342661 creator A5084367706 @default.
- W2792342661 date "2018-03-25" @default.
- W2792342661 modified "2023-10-03" @default.
- W2792342661 title "Antimalarial drug mefloquine inhibits nuclear factor kappa B signaling and induces apoptosis in colorectal cancer cells" @default.
- W2792342661 cites W1661180389 @default.
- W2792342661 cites W1880594232 @default.
- W2792342661 cites W1969540068 @default.
- W2792342661 cites W1981140858 @default.
- W2792342661 cites W1981631184 @default.
- W2792342661 cites W1997546288 @default.
- W2792342661 cites W2014167280 @default.
- W2792342661 cites W2030330457 @default.
- W2792342661 cites W2038713860 @default.
- W2792342661 cites W2071018175 @default.
- W2792342661 cites W2073333066 @default.
- W2792342661 cites W2074688366 @default.
- W2792342661 cites W2100196889 @default.
- W2792342661 cites W2102924561 @default.
- W2792342661 cites W2112067370 @default.
- W2792342661 cites W2146654374 @default.
- W2792342661 cites W2147846943 @default.
- W2792342661 cites W2158708535 @default.
- W2792342661 cites W2162880554 @default.
- W2792342661 cites W2213222087 @default.
- W2792342661 cites W2217342753 @default.
- W2792342661 cites W2297237332 @default.
- W2792342661 cites W2323468907 @default.
- W2792342661 cites W2331046626 @default.
- W2792342661 cites W2336653647 @default.
- W2792342661 cites W2406655698 @default.
- W2792342661 cites W2417413830 @default.
- W2792342661 cites W2516573438 @default.
- W2792342661 cites W2517730488 @default.
- W2792342661 cites W2525190022 @default.
- W2792342661 cites W2526983829 @default.
- W2792342661 cites W2536777088 @default.
- W2792342661 cites W2571341150 @default.
- W2792342661 cites W2579021825 @default.
- W2792342661 cites W2583759277 @default.
- W2792342661 cites W2586735881 @default.
- W2792342661 cites W2594281373 @default.
- W2792342661 cites W2611295065 @default.
- W2792342661 cites W2614162828 @default.
- W2792342661 cites W2755958285 @default.
- W2792342661 cites W2761923993 @default.
- W2792342661 doi "https://doi.org/10.1111/cas.13540" @default.
- W2792342661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5891192" @default.
- W2792342661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29453896" @default.
- W2792342661 hasPublicationYear "2018" @default.
- W2792342661 type Work @default.
- W2792342661 sameAs 2792342661 @default.
- W2792342661 citedByCount "44" @default.
- W2792342661 countsByYear W27923426612018 @default.
- W2792342661 countsByYear W27923426612019 @default.
- W2792342661 countsByYear W27923426612020 @default.
- W2792342661 countsByYear W27923426612021 @default.
- W2792342661 countsByYear W27923426612022 @default.
- W2792342661 countsByYear W27923426612023 @default.
- W2792342661 crossrefType "journal-article" @default.
- W2792342661 hasAuthorship W2792342661A5003646610 @default.
- W2792342661 hasAuthorship W2792342661A5042241049 @default.
- W2792342661 hasAuthorship W2792342661A5050319118 @default.
- W2792342661 hasAuthorship W2792342661A5063718631 @default.
- W2792342661 hasAuthorship W2792342661A5065753985 @default.
- W2792342661 hasAuthorship W2792342661A5084367706 @default.
- W2792342661 hasBestOaLocation W27923426611 @default.
- W2792342661 hasConcept C100175707 @default.
- W2792342661 hasConcept C121608353 @default.
- W2792342661 hasConcept C126322002 @default.
- W2792342661 hasConcept C154317977 @default.
- W2792342661 hasConcept C184235292 @default.
- W2792342661 hasConcept C190283241 @default.
- W2792342661 hasConcept C202751555 @default.
- W2792342661 hasConcept C203014093 @default.
- W2792342661 hasConcept C2777199930 @default.
- W2792342661 hasConcept C2777425658 @default.
- W2792342661 hasConcept C2777730290 @default.
- W2792342661 hasConcept C2778048844 @default.
- W2792342661 hasConcept C502942594 @default.
- W2792342661 hasConcept C526805850 @default.
- W2792342661 hasConcept C55493867 @default.
- W2792342661 hasConcept C62478195 @default.
- W2792342661 hasConcept C71924100 @default.
- W2792342661 hasConcept C86803240 @default.
- W2792342661 hasConcept C95444343 @default.
- W2792342661 hasConcept C98274493 @default.
- W2792342661 hasConceptScore W2792342661C100175707 @default.
- W2792342661 hasConceptScore W2792342661C121608353 @default.
- W2792342661 hasConceptScore W2792342661C126322002 @default.
- W2792342661 hasConceptScore W2792342661C154317977 @default.
- W2792342661 hasConceptScore W2792342661C184235292 @default.