Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792368997> ?p ?o ?g. }
- W2792368997 abstract "Reproductive abnormalities are included as health complications in offspring exposed to poor prenatal nutrition. We have previously shown in a rodent model that offspring born to nutrient restriction during pregnancy are born small, enter puberty early, and display characteristics of early ovarian aging as adults. The present study investigated whether key proteins involved in follicle recruitment and growth mediate ovarian follicle loss. Pregnant rats were randomized to a standard diet throughout pregnancy and lactation (CON), or a calorie-restricted (50% of control) diet (UN) during pregnancy. Offspring reproductive phenotype was investigated at postnatal days 4, 27, and 65. Maternal UN resulted in young adult (P65) irregular estrous cyclicity due to persistent estrus, a significant loss of antral follicles, corpora lutea, and an increase in atretic follicles. This decrease in growing follicles in UN offspring appears to be due to increased apoptosis as seen by immunopositive staining of pro-apoptotic factor CASP3 (caspase 3) in ovaries of young adult offspring. UN prepubertal offspring had reduced expression levels of Fshr in antral follicles, which may contribute to a decrease in PI3K/AKT activation evident as a decrease in pAKT immunolocalization in prepubertal antral follicles. Moreover, neonatal ovaries of UN offspring show decreased levels of immunopositive staining for AMHR2 (anti-mullerian hormone receptor 2). Collectively, these data demonstrate that maternal UN during pregnancy impacts ovarian function in offspring as early as P65 and provides a model for understanding the mechanisms driving early life UN-induced follicle loss and reproductive dysfunction." @default.
- W2792368997 created "2018-03-29" @default.
- W2792368997 creator A5002967502 @default.
- W2792368997 creator A5007276346 @default.
- W2792368997 creator A5013270267 @default.
- W2792368997 creator A5071283689 @default.
- W2792368997 creator A5086968302 @default.
- W2792368997 date "2018-01-17" @default.
- W2792368997 modified "2023-09-26" @default.
- W2792368997 title "Maternal nutrient restriction impairs young adult offspring ovarian signaling resulting in reproductive dysfunction and follicle loss†" @default.
- W2792368997 cites W1556284416 @default.
- W2792368997 cites W1584985779 @default.
- W2792368997 cites W1967199332 @default.
- W2792368997 cites W1982575480 @default.
- W2792368997 cites W1985661983 @default.
- W2792368997 cites W1986704518 @default.
- W2792368997 cites W1990440494 @default.
- W2792368997 cites W1994489910 @default.
- W2792368997 cites W1996613476 @default.
- W2792368997 cites W1999838161 @default.
- W2792368997 cites W2000544678 @default.
- W2792368997 cites W2007447150 @default.
- W2792368997 cites W2011880080 @default.
- W2792368997 cites W2018651267 @default.
- W2792368997 cites W2023113576 @default.
- W2792368997 cites W2024497388 @default.
- W2792368997 cites W2027782206 @default.
- W2792368997 cites W2027929338 @default.
- W2792368997 cites W2028065219 @default.
- W2792368997 cites W2033484016 @default.
- W2792368997 cites W2035170450 @default.
- W2792368997 cites W2047453699 @default.
- W2792368997 cites W2049698925 @default.
- W2792368997 cites W2052103587 @default.
- W2792368997 cites W2057313063 @default.
- W2792368997 cites W2058109286 @default.
- W2792368997 cites W2060321330 @default.
- W2792368997 cites W2061595117 @default.
- W2792368997 cites W2061702838 @default.
- W2792368997 cites W2067336113 @default.
- W2792368997 cites W2070906481 @default.
- W2792368997 cites W2073149243 @default.
- W2792368997 cites W2080172457 @default.
- W2792368997 cites W2082348242 @default.
- W2792368997 cites W2085679334 @default.
- W2792368997 cites W2085923909 @default.
- W2792368997 cites W2086664003 @default.
- W2792368997 cites W2089128420 @default.
- W2792368997 cites W2090489384 @default.
- W2792368997 cites W2094994526 @default.
- W2792368997 cites W2095233493 @default.
- W2792368997 cites W2095637251 @default.
- W2792368997 cites W2097540678 @default.
- W2792368997 cites W2099702361 @default.
- W2792368997 cites W2101266059 @default.
- W2792368997 cites W2101524853 @default.
- W2792368997 cites W2105226571 @default.
- W2792368997 cites W2107277218 @default.
- W2792368997 cites W2113154513 @default.
- W2792368997 cites W2114570899 @default.
- W2792368997 cites W2115560018 @default.
- W2792368997 cites W2116940393 @default.
- W2792368997 cites W2117303232 @default.
- W2792368997 cites W2117844201 @default.
- W2792368997 cites W2119939510 @default.
- W2792368997 cites W2125639197 @default.
- W2792368997 cites W2127382664 @default.
- W2792368997 cites W2131204570 @default.
- W2792368997 cites W2132044686 @default.
- W2792368997 cites W2134989837 @default.
- W2792368997 cites W2137035181 @default.
- W2792368997 cites W2138714285 @default.
- W2792368997 cites W2148070806 @default.
- W2792368997 cites W2150456795 @default.
- W2792368997 cites W2152070401 @default.
- W2792368997 cites W2155196041 @default.
- W2792368997 cites W2160322468 @default.
- W2792368997 cites W2167291975 @default.
- W2792368997 cites W2168653088 @default.
- W2792368997 cites W2200440629 @default.
- W2792368997 cites W2292991887 @default.
- W2792368997 cites W2406301800 @default.
- W2792368997 cites W2885831457 @default.
- W2792368997 cites W4299305924 @default.
- W2792368997 doi "https://doi.org/10.1093/biolre/ioy008" @default.
- W2792368997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29351580" @default.
- W2792368997 hasPublicationYear "2018" @default.
- W2792368997 type Work @default.
- W2792368997 sameAs 2792368997 @default.
- W2792368997 citedByCount "9" @default.
- W2792368997 countsByYear W27923689972018 @default.
- W2792368997 countsByYear W27923689972019 @default.
- W2792368997 countsByYear W27923689972020 @default.
- W2792368997 countsByYear W27923689972022 @default.
- W2792368997 countsByYear W27923689972023 @default.
- W2792368997 crossrefType "journal-article" @default.
- W2792368997 hasAuthorship W2792368997A5002967502 @default.
- W2792368997 hasAuthorship W2792368997A5007276346 @default.
- W2792368997 hasAuthorship W2792368997A5013270267 @default.
- W2792368997 hasAuthorship W2792368997A5071283689 @default.