FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792377523> ?p ?o ?g. }

• W2792377523 endingPage "450" @default.
• W2792377523 startingPage "444" @default.
• W2792377523 abstract "We previously reported that 5-methoxyindole-2-carboxylic acid (MICA) could induce preconditioning effect in the ischemic brain of rat. In the present study, we addressed the question of whether MICA could also trigger a postconditioning effect in ischemic stroke. To this end, MICA (100 mg/kg body weight) was injected intraperitoneally at the onset of 24 h reperfusion following 1 h ischemia in rat brain. Results indicate that stroked animals treated with MICA showed less brain infarction volume than that of vehicle-treated animals. Further experiments revealed that brain mitochondrial complexes I and IV showed elevated enzymatic activities in MICA treated group and the elevation in complex I activity was likely contributed by seemingly enhanced expression of many complex I subunits, which was determined by mass spectral peptide sequencing. When compared with vehicle-treated rats, the preservation of complexes I and IV activities was shown to be accompanied by enhanced mitochondrial membrane potential, increased ATP production, and decreased caspase-3 activity. Additional studies also indicate the involvement of NQO1 upregulation by the Nrf2 signaling pathway in this MICA postconditioning paradigm. Consequently, attenuated oxidative stress in the MICA treated group reflected by decrease in H2O2 production and protein carbonylation and lipid peroxidation was detected. Taken together, the present study demonstrates that MICA can also induce a postconditioning effect in the ischemic brain of rat and the underlying mechanism likely involves preservation of mitochondrial function, upregulation of cellular antioxidative capacity, and attenuation of oxidative stress." @default.
• W2792377523 created "2018-03-29" @default.
• W2792377523 creator A5024961053 @default.
• W2792377523 creator A5046378016 @default.
• W2792377523 creator A5068717952 @default.
• W2792377523 creator A5071374687 @default.
• W2792377523 date "2018-02-01" @default.
• W2792377523 modified "2023-09-27" @default.
• W2792377523 title "Post-ischemic administration of 5-methoxyindole-2-carboxylic acid at the onset of reperfusion affords neuroprotection against stroke injury by preserving mitochondrial function and attenuating oxidative stress" @default.
• W2792377523 cites W1417333514 @default.
• W2792377523 cites W1584771014 @default.
• W2792377523 cites W1594698135 @default.
• W2792377523 cites W1596958478 @default.
• W2792377523 cites W1604748982 @default.
• W2792377523 cites W1922324982 @default.
• W2792377523 cites W1963744019 @default.
• W2792377523 cites W1973503381 @default.
• W2792377523 cites W1976252254 @default.
• W2792377523 cites W1980821178 @default.
• W2792377523 cites W1980829692 @default.
• W2792377523 cites W1985419968 @default.
• W2792377523 cites W2000609570 @default.
• W2792377523 cites W2001564891 @default.
• W2792377523 cites W2002301670 @default.
• W2792377523 cites W2011136055 @default.
• W2792377523 cites W2013557200 @default.
• W2792377523 cites W2020686712 @default.
• W2792377523 cites W2026180855 @default.
• W2792377523 cites W2028958046 @default.
• W2792377523 cites W2037339767 @default.
• W2792377523 cites W2040529452 @default.
• W2792377523 cites W2054695233 @default.
• W2792377523 cites W2069964279 @default.
• W2792377523 cites W2070263356 @default.
• W2792377523 cites W2079602786 @default.
• W2792377523 cites W2082668576 @default.
• W2792377523 cites W2089960919 @default.
• W2792377523 cites W2091509954 @default.
• W2792377523 cites W2094662285 @default.
• W2792377523 cites W2100545066 @default.
• W2792377523 cites W2103857217 @default.
• W2792377523 cites W2113480020 @default.
• W2792377523 cites W2128794432 @default.
• W2792377523 cites W2160667443 @default.
• W2792377523 cites W2166159893 @default.
• W2792377523 cites W2166660871 @default.
• W2792377523 cites W2193953481 @default.
• W2792377523 cites W2217900354 @default.
• W2792377523 cites W2294734462 @default.
• W2792377523 cites W2555985376 @default.
• W2792377523 cites W2762177595 @default.
• W2792377523 cites W4293247451 @default.
• W2792377523 doi "https://doi.org/10.1016/j.bbrc.2018.02.106" @default.
• W2792377523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5835215" @default.
• W2792377523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29448100" @default.
• W2792377523 hasPublicationYear "2018" @default.
• W2792377523 type Work @default.
• W2792377523 sameAs 2792377523 @default.
• W2792377523 citedByCount "18" @default.
• W2792377523 countsByYear W27923775232018 @default.
• W2792377523 countsByYear W27923775232019 @default.
• W2792377523 countsByYear W27923775232020 @default.
• W2792377523 countsByYear W27923775232021 @default.
• W2792377523 countsByYear W27923775232022 @default.
• W2792377523 countsByYear W27923775232023 @default.
• W2792377523 crossrefType "journal-article" @default.
• W2792377523 hasAuthorship W2792377523A5024961053 @default.
• W2792377523 hasAuthorship W2792377523A5046378016 @default.
• W2792377523 hasAuthorship W2792377523A5068717952 @default.
• W2792377523 hasAuthorship W2792377523A5071374687 @default.
• W2792377523 hasBestOaLocation W27923775232 @default.
• W2792377523 hasConcept C104317684 @default.
• W2792377523 hasConcept C126322002 @default.
• W2792377523 hasConcept C127561419 @default.
• W2792377523 hasConcept C134018914 @default.
• W2792377523 hasConcept C185592680 @default.
• W2792377523 hasConcept C25498285 @default.
• W2792377523 hasConcept C2776151105 @default.
• W2792377523 hasConcept C2779311647 @default.
• W2792377523 hasConcept C2780114680 @default.
• W2792377523 hasConcept C2780829032 @default.
• W2792377523 hasConcept C28859421 @default.
• W2792377523 hasConcept C541997718 @default.
• W2792377523 hasConcept C55493867 @default.
• W2792377523 hasConcept C71924100 @default.
• W2792377523 hasConcept C75385678 @default.
• W2792377523 hasConcept C98274493 @default.
• W2792377523 hasConceptScore W2792377523C104317684 @default.
• W2792377523 hasConceptScore W2792377523C126322002 @default.
• W2792377523 hasConceptScore W2792377523C127561419 @default.
• W2792377523 hasConceptScore W2792377523C134018914 @default.
• W2792377523 hasConceptScore W2792377523C185592680 @default.
• W2792377523 hasConceptScore W2792377523C25498285 @default.
• W2792377523 hasConceptScore W2792377523C2776151105 @default.
• W2792377523 hasConceptScore W2792377523C2779311647 @default.
• W2792377523 hasConceptScore W2792377523C2780114680 @default.
• W2792377523 hasConceptScore W2792377523C2780829032 @default.
• W2792377523 hasConceptScore W2792377523C28859421 @default.

• next