FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792395386> ?p ?o ?g. }

• W2792395386 endingPage "159" @default.
• W2792395386 startingPage "150" @default.
• W2792395386 abstract "Genetic ablation of cyclooxygenase-2 (COX-2) in mice is known to impair fracture healing. To determine if teriparatide (human PTH1-34) can promote healing of Cox-2-deficient fractures, we performed detailed in vivo analyses using a murine stabilized tibia fracture model. Periosteal progenitor cell proliferation as well as bony callus formation was markedly reduced in Cox-2-/- mice at day 10 post-fracture. Remarkably, intermittent PTH1-34 administration increased proliferation of periosteal progenitor cells, restored callus formation on day 7, and enhanced bone formation on days 10, 14 and 21 in Cox-2-deficient mice. PTH1-34 also increased biomechanical torsional properties at days 10 or 14 in all genotypes, consistent with enhanced bony callus formation by radiologic examinations. To determine the effects of intermittent PTH1-34 for callus remodeling, TRAP staining was performed. Intermittent PTH1-34 treatment increased the number of TRAP positive cells per total callus area on day 21 in Cox-2-/- fractures. Taken together, the present findings indicate that intermittent PTH1-34 treatment could compensate for COX-2 deficiency and improve impaired fracture healing in Cox-2-deficient mice." @default.
• W2792395386 created "2018-03-29" @default.
• W2792395386 creator A5008910146 @default.
• W2792395386 creator A5010323164 @default.
• W2792395386 creator A5024783120 @default.
• W2792395386 creator A5047355787 @default.
• W2792395386 creator A5050195432 @default.
• W2792395386 creator A5054530372 @default.
• W2792395386 creator A5072046074 @default.
• W2792395386 creator A5074891524 @default.
• W2792395386 creator A5075595424 @default.
• W2792395386 creator A5089699585 @default.
• W2792395386 creator A5091373462 @default.
• W2792395386 date "2018-05-01" @default.
• W2792395386 modified "2023-10-14" @default.
• W2792395386 title "Teriparatide (human PTH1–34) compensates for impaired fracture healing in COX-2 deficient mice" @default.
• W2792395386 cites W1964005120 @default.
• W2792395386 cites W1965100070 @default.
• W2792395386 cites W1966994557 @default.
• W2792395386 cites W1971440540 @default.
• W2792395386 cites W1971482740 @default.
• W2792395386 cites W1978319195 @default.
• W2792395386 cites W1983512141 @default.
• W2792395386 cites W1984588551 @default.
• W2792395386 cites W1994169116 @default.
• W2792395386 cites W1995882765 @default.
• W2792395386 cites W1996487528 @default.
• W2792395386 cites W1996656034 @default.
• W2792395386 cites W1998728209 @default.
• W2792395386 cites W2001982119 @default.
• W2792395386 cites W2003571415 @default.
• W2792395386 cites W2004498172 @default.
• W2792395386 cites W2008778656 @default.
• W2792395386 cites W2018318619 @default.
• W2792395386 cites W2032491472 @default.
• W2792395386 cites W2034096766 @default.
• W2792395386 cites W2034569221 @default.
• W2792395386 cites W2039731841 @default.
• W2792395386 cites W2043739948 @default.
• W2792395386 cites W2044573417 @default.
• W2792395386 cites W2045503800 @default.
• W2792395386 cites W2046862403 @default.
• W2792395386 cites W2048019049 @default.
• W2792395386 cites W2052192250 @default.
• W2792395386 cites W2056595783 @default.
• W2792395386 cites W2058778192 @default.
• W2792395386 cites W2075355171 @default.
• W2792395386 cites W2076020535 @default.
• W2792395386 cites W2076174004 @default.
• W2792395386 cites W2083651943 @default.
• W2792395386 cites W2087006405 @default.
• W2792395386 cites W2088958890 @default.
• W2792395386 cites W2092369211 @default.
• W2792395386 cites W2093033478 @default.
• W2792395386 cites W2100200742 @default.
• W2792395386 cites W2100754175 @default.
• W2792395386 cites W2104682440 @default.
• W2792395386 cites W2107010463 @default.
• W2792395386 cites W2108783581 @default.
• W2792395386 cites W2116515339 @default.
• W2792395386 cites W2117769089 @default.
• W2792395386 cites W2121023034 @default.
• W2792395386 cites W2122427056 @default.
• W2792395386 cites W2134427840 @default.
• W2792395386 cites W2136953476 @default.
• W2792395386 cites W2138022846 @default.
• W2792395386 cites W2140672532 @default.
• W2792395386 cites W2143214738 @default.
• W2792395386 cites W2148437430 @default.
• W2792395386 cites W2152121980 @default.
• W2792395386 cites W2152216439 @default.
• W2792395386 cites W2170805988 @default.
• W2792395386 cites W2335178464 @default.
• W2792395386 cites W2725056820 @default.
• W2792395386 cites W4236708194 @default.
• W2792395386 doi "https://doi.org/10.1016/j.bone.2018.02.001" @default.
• W2792395386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5878736" @default.
• W2792395386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29408411" @default.
• W2792395386 hasPublicationYear "2018" @default.
• W2792395386 type Work @default.
• W2792395386 sameAs 2792395386 @default.
• W2792395386 citedByCount "12" @default.
• W2792395386 countsByYear W27923953862018 @default.
• W2792395386 countsByYear W27923953862019 @default.
• W2792395386 countsByYear W27923953862020 @default.
• W2792395386 countsByYear W27923953862021 @default.
• W2792395386 countsByYear W27923953862022 @default.
• W2792395386 countsByYear W27923953862023 @default.
• W2792395386 crossrefType "journal-article" @default.
• W2792395386 hasAuthorship W2792395386A5008910146 @default.
• W2792395386 hasAuthorship W2792395386A5010323164 @default.
• W2792395386 hasAuthorship W2792395386A5024783120 @default.
• W2792395386 hasAuthorship W2792395386A5047355787 @default.
• W2792395386 hasAuthorship W2792395386A5050195432 @default.
• W2792395386 hasAuthorship W2792395386A5054530372 @default.
• W2792395386 hasAuthorship W2792395386A5072046074 @default.
• W2792395386 hasAuthorship W2792395386A5074891524 @default.
• W2792395386 hasAuthorship W2792395386A5075595424 @default.

• next