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• W2792411268 abstract "In this work, the potential antimicrobial role and mechanism of action of α-helix domain of trout and salmon IL-8 against Eschericia coli, Pseudomonas aeruginosa and Staphylococcus aureus was investigated. By an in silico analysis of the primary structure of IL-8 from Oncorhynchus mykiss and salmo salar, it was evidenced that γ-core motif was present, as in the vast majority of kinocidins. The α-helix domain of IL-8 (αIL-8) was synthesized by solid phase peptide synthesis and showed a tendency to form an α-helix conformation, as revealed by circular dichroism. Additionally, it was demonstrated that αIL-8 from both species showed antimicrobial activity against E. coli, P. aeruginosa and S. aureus. Membrane permeabilization and co-localization assay, as well as scanning electron microscopy, showed that these peptides were accumulated on the cell surface and in the cytoplasm, suggesting that they were capable of permeabilizing and disrupt the bacterial membranes and interact with cytoplasmic components. Our results represent the first analysis on the antimicrobial function of IL-8-derived peptide from salmonids." @default.
• W2792411268 created "2018-03-29" @default.
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• W2792411268 date "2018-04-01" @default.
• W2792411268 modified "2023-10-16" @default.
• W2792411268 title "Alpha-helical domain from IL-8 of salmonids: Mechanism of action and identification of a novel antimicrobial function" @default.
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• W2792411268 doi "https://doi.org/10.1016/j.bbrc.2018.03.061" @default.
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