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- W2792424265 endingPage "262" @default.
- W2792424265 startingPage "248" @default.
- W2792424265 abstract "Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of renal survival. Many different cell types contribute to TIF progression including tubular epithelial cells, myofibroblasts, endothelia, and inflammatory cells. Previously, most of the attention has centered on myofibroblasts given their central importance in extracellular matrix production. However, emerging data focuses on how the response of the proximal tubule, a specialized epithelial segment vulnerable to injury, plays a central role in TIF progression. Several proximal tubular responses such as de-differentiation, cell cycle changes, autophagy, and metabolic changes may be adaptive initially, but can lead to maladaptive responses that promote TIF both through autocrine and paracrine effects. This review discusses the current paradigm of TIF progression and the increasingly important role of the proximal tubule in promoting TIF both in tubulointerstitial and glomerular injuries. A better understanding and appreciation of the role of the proximal tubule in TIF has important implications for therapeutic strategies to halt chronic kidney disease progression." @default.
- W2792424265 created "2018-03-29" @default.
- W2792424265 creator A5090425922 @default.
- W2792424265 date "2018-08-01" @default.
- W2792424265 modified "2023-10-01" @default.
- W2792424265 title "Renal fibrosis: Primacy of the proximal tubule" @default.
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