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• W2792436446 endingPage "1972" @default.
• W2792436446 startingPage "1959" @default.
• W2792436446 abstract "DNA ‐dependent protein kinase ( DNA ‐ PK ) is a very large holoenzyme comprised of the p470 kDa DNA ‐ PK catalytic subunit ( DNA ‐ PK cs ) and the Ku heterodimer consisting of the p86 (Ku 80) and p70 (Ku 70) subunits. It is best known for its nonhomologous end joining ( NHEJ ) activity, which repairs double‐strand DNA (ds DNA ) breaks ( DSB s). As expected, the absence of DNA ‐ PK activity results in sensitivity to ionizing radiation, which generates DSB s and defect in lymphocyte development, which requires NHEJ of the V(D)J region in the immunoglobulin and T‐cell receptor loci. DNA ‐ PK also has been reported to have functions seemingly unrelated to NHEJ . For example, DNA ‐ PK responds to insulin signaling to facilitate the conversion of carbohydrates to fatty acids in the liver. More recent evidence indicates that DNA ‐ PK activity increases with age in skeletal muscle, promoting mitochondrial loss and weight gain. These discoveries suggest that our understanding of DNA ‐ PK is far from complete. As many excellent reviews have already been written about the role of DNA ‐ PK in NHEJ , here we will review the non‐ NHEJ role of DNA ‐ PK with a focus on its role in aging and energy metabolism." @default.
• W2792436446 created "2018-03-29" @default.
• W2792436446 creator A5029848713 @default.
• W2792436446 date "2018-03-12" @default.
• W2792436446 modified "2023-10-13" @default.
• W2792436446 title "The role of <scp>DNA</scp>‐<scp>PK</scp> in aging and energy metabolism" @default.
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