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• W2792445919 abstract "<b><i>Background:</i></b> Approximately 10% of Crohn’s disease (CD) patients have this disease affecting the small bowel (SB) beyond the reach of Ileo-colonoscopy. Capsule endoscopy (SBCE) is the recommended investigation for SB disease. An accurate and inexpensive biomarker would help identify at-risk patients. <b><i>Aim:</i></b> To examine the efficacy of faecal calprotectin (FC) and C-reactive protein (CRP) as predictors of SBCE findings in suspected and known CD. <b><i>Methods:</i></b> A prospective observational study. Consecutive patients referred for SBCE gave FC and CRP samples. The diagnostic accuracy for SB CD based on SBCE result was calculated for both FC and CRP. <b><i>Results:</i></b> Of 100 invitees, FC and SBCE results were available in 64 cases. Correlation between FC &#x3e;50 µg/g and SBCE result was poor К = 0.163; sensitivity, specificity, positive predictive value (PPV) and negative predictive values for ileitis were 60, 61, 32 and 83% respectively. PPV and specificity improved at FC &#x3e;100 µg/g, 76 and 40%, correlation remained fair, К = 0.259. Receiver operating characteristic analysis had a sensitivity of 47% and specificity of 90% for FC &#x3e;194 µg/g. CRP alone or in combination was an inaccurate predictor of ileitis. <b><i>Conclusion:</i></b> Our study suggests that FC level &#x3e;194 µg/g may be a useful SBCE filter test, identifying patients at risk of SB CD." @default.
• W2792445919 created "2018-03-29" @default.
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• W2792445919 date "2018-01-01" @default.
• W2792445919 modified "2023-09-24" @default.
• W2792445919 title "Elevated Faecal Calprotectin Levels are a Reliable Non-Invasive Screening Tool for Small Bowel Crohn’s Disease in Patients Undergoing Capsule Endoscopy" @default.
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• W2792445919 doi "https://doi.org/10.1159/000485375" @default.
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