FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792479842> ?p ?o ?g. }

• W2792479842 endingPage "1476" @default.
• W2792479842 startingPage "1466" @default.
• W2792479842 abstract "Oncogenic fusions are major drivers in leukemogenesis and may serve as potent targets for treatment. DUX4/IGHs have been shown to trigger the abnormal expression of ERGalt through binding to DUX4-Responsive-Element (DRE), which leads to B-cell differentiation arrest and a full-fledged B-ALL. Here, we determined the crystal structures of Apo- and DNADRE-bound DUX4HD2 and revealed a clamp-like transactivation mechanism via the double homeobox domain. Biophysical characterization showed that mutations in the interacting interfaces significantly impaired the DNA binding affinity of DUX4 homeobox. These mutations, when introduced into DUX4/IGH, abrogated its transactivation activity in Reh cells. More importantly, the structure-based mutants significantly impaired the inhibitory effects of DUX4/IGH upon B-cell differentiation in mouse progenitor cells. All these results help to define a key DUX4/IGH-DRE recognition/step in B-ALL." @default.
• W2792479842 created "2018-03-29" @default.
• W2792479842 creator A5012352582 @default.
• W2792479842 creator A5023634611 @default.
• W2792479842 creator A5025570473 @default.
• W2792479842 creator A5044277116 @default.
• W2792479842 creator A5074908774 @default.
• W2792479842 creator A5079046653 @default.
• W2792479842 creator A5079369842 @default.
• W2792479842 creator A5080733133 @default.
• W2792479842 creator A5082424766 @default.
• W2792479842 creator A5083870002 @default.
• W2792479842 date "2018-03-15" @default.
• W2792479842 modified "2023-10-13" @default.
• W2792479842 title "Structural basis of DUX4/IGH-driven transactivation" @default.
• W2792479842 cites W117387909 @default.
• W2792479842 cites W1801876107 @default.
• W2792479842 cites W1984065010 @default.
• W2792479842 cites W1984143972 @default.
• W2792479842 cites W1994881558 @default.
• W2792479842 cites W1996490076 @default.
• W2792479842 cites W2005559239 @default.
• W2792479842 cites W2007804646 @default.
• W2792479842 cites W2015448530 @default.
• W2792479842 cites W2017035463 @default.
• W2792479842 cites W2017040061 @default.
• W2792479842 cites W2018380248 @default.
• W2792479842 cites W2020342155 @default.
• W2792479842 cites W2023594790 @default.
• W2792479842 cites W2024996887 @default.
• W2792479842 cites W2038856813 @default.
• W2792479842 cites W2045832625 @default.
• W2792479842 cites W2052246089 @default.
• W2792479842 cites W2081357269 @default.
• W2792479842 cites W2108333425 @default.
• W2792479842 cites W2127184995 @default.
• W2792479842 cites W2166641737 @default.
• W2792479842 cites W2167593243 @default.
• W2792479842 cites W2335147237 @default.
• W2792479842 cites W2340021583 @default.
• W2792479842 cites W2351547314 @default.
• W2792479842 cites W2472572141 @default.
• W2792479842 cites W2522312228 @default.
• W2792479842 cites W2535017817 @default.
• W2792479842 cites W2611165465 @default.
• W2792479842 cites W2611346822 @default.
• W2792479842 cites W4254829742 @default.
• W2792479842 doi "https://doi.org/10.1038/s41375-018-0093-1" @default.
• W2792479842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5990521" @default.
• W2792479842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29572508" @default.
• W2792479842 hasPublicationYear "2018" @default.
• W2792479842 type Work @default.
• W2792479842 sameAs 2792479842 @default.
• W2792479842 citedByCount "19" @default.
• W2792479842 countsByYear W27924798422018 @default.
• W2792479842 countsByYear W27924798422019 @default.
• W2792479842 countsByYear W27924798422020 @default.
• W2792479842 countsByYear W27924798422021 @default.
• W2792479842 countsByYear W27924798422022 @default.
• W2792479842 countsByYear W27924798422023 @default.
• W2792479842 crossrefType "journal-article" @default.
• W2792479842 hasAuthorship W2792479842A5012352582 @default.
• W2792479842 hasAuthorship W2792479842A5023634611 @default.
• W2792479842 hasAuthorship W2792479842A5025570473 @default.
• W2792479842 hasAuthorship W2792479842A5044277116 @default.
• W2792479842 hasAuthorship W2792479842A5074908774 @default.
• W2792479842 hasAuthorship W2792479842A5079046653 @default.
• W2792479842 hasAuthorship W2792479842A5079369842 @default.
• W2792479842 hasAuthorship W2792479842A5080733133 @default.
• W2792479842 hasAuthorship W2792479842A5082424766 @default.
• W2792479842 hasAuthorship W2792479842A5083870002 @default.
• W2792479842 hasBestOaLocation W27924798421 @default.
• W2792479842 hasConcept C104317684 @default.
• W2792479842 hasConcept C121587040 @default.
• W2792479842 hasConcept C1292079 @default.
• W2792479842 hasConcept C143065580 @default.
• W2792479842 hasConcept C153911025 @default.
• W2792479842 hasConcept C201750760 @default.
• W2792479842 hasConcept C28328180 @default.
• W2792479842 hasConcept C501734568 @default.
• W2792479842 hasConcept C502942594 @default.
• W2792479842 hasConcept C54355233 @default.
• W2792479842 hasConcept C86339819 @default.
• W2792479842 hasConcept C86803240 @default.
• W2792479842 hasConcept C95444343 @default.
• W2792479842 hasConceptScore W2792479842C104317684 @default.
• W2792479842 hasConceptScore W2792479842C121587040 @default.
• W2792479842 hasConceptScore W2792479842C1292079 @default.
• W2792479842 hasConceptScore W2792479842C143065580 @default.
• W2792479842 hasConceptScore W2792479842C153911025 @default.
• W2792479842 hasConceptScore W2792479842C201750760 @default.
• W2792479842 hasConceptScore W2792479842C28328180 @default.
• W2792479842 hasConceptScore W2792479842C501734568 @default.
• W2792479842 hasConceptScore W2792479842C502942594 @default.
• W2792479842 hasConceptScore W2792479842C54355233 @default.
• W2792479842 hasConceptScore W2792479842C86339819 @default.
• W2792479842 hasConceptScore W2792479842C86803240 @default.
• W2792479842 hasConceptScore W2792479842C95444343 @default.

• next