Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792566138> ?p ?o ?g. }
- W2792566138 endingPage "105" @default.
- W2792566138 startingPage "95" @default.
- W2792566138 abstract "miR‐222 plays an important role in erythroid differentiation, but the potential targets of miR‐222 in the regulation of erythroid differentiation remain to be determined. The target genes of miR‐222 were identified by proteomics combined with bioinformatics analysis in this study. Thirteen proteins were upregulated, and 13 were downregulated in K562 cells following transfection with miR‐222 inhibitor for 24 and 48 hours. Among these proteins, BLVRA and CRKL were upregulated after transfection of miR‐222 inhibitor in K562 cells and human CD34+ HPCs. Moreover, miR‐222 mimics reduced and miR‐222 inhibitor enhanced the mRNA and protein levels of both BLVRA and CRKL. Luciferase assay showed that miR‐222 directly targeted 3′‐UTR of BLVRA and CRKL. In addition, overexpression of either BLVRA or CRKL or both increased the erythroid differentiation of K562 cells, while silencing of either BLVRA or CRKL or both by siRNA significantly attenuated hemin‐induced erythroid differentiation of K562 cells. Our results indicated that BLVRA and CRKL are targets of miR‐222." @default.
- W2792566138 created "2018-03-29" @default.
- W2792566138 creator A5001219472 @default.
- W2792566138 creator A5055441139 @default.
- W2792566138 creator A5066102428 @default.
- W2792566138 creator A5079543320 @default.
- W2792566138 date "2018-01-24" @default.
- W2792566138 modified "2023-10-17" @default.
- W2792566138 title "Quantitative proteomics reveals that miR-222 inhibits erythroid differentiation by targeting BLVRA and CRKL" @default.
- W2792566138 cites W1481345637 @default.
- W2792566138 cites W1963869282 @default.
- W2792566138 cites W1975176787 @default.
- W2792566138 cites W1980504189 @default.
- W2792566138 cites W1981330103 @default.
- W2792566138 cites W1991102898 @default.
- W2792566138 cites W1993102261 @default.
- W2792566138 cites W2001937658 @default.
- W2792566138 cites W2004045031 @default.
- W2792566138 cites W2005645711 @default.
- W2792566138 cites W2026145229 @default.
- W2792566138 cites W2027218099 @default.
- W2792566138 cites W2028185878 @default.
- W2792566138 cites W2031292552 @default.
- W2792566138 cites W2037141750 @default.
- W2792566138 cites W2037445609 @default.
- W2792566138 cites W2067451494 @default.
- W2792566138 cites W2067788694 @default.
- W2792566138 cites W2076774361 @default.
- W2792566138 cites W2081709185 @default.
- W2792566138 cites W2087206434 @default.
- W2792566138 cites W2087720482 @default.
- W2792566138 cites W2088077435 @default.
- W2792566138 cites W2090049422 @default.
- W2792566138 cites W2099244520 @default.
- W2792566138 cites W2101300574 @default.
- W2792566138 cites W2107277218 @default.
- W2792566138 cites W2114570899 @default.
- W2792566138 cites W2120112580 @default.
- W2792566138 cites W2123509656 @default.
- W2792566138 cites W2125939997 @default.
- W2792566138 cites W2127683351 @default.
- W2792566138 cites W2129852181 @default.
- W2792566138 cites W2133968430 @default.
- W2792566138 cites W2149623095 @default.
- W2792566138 cites W2152183440 @default.
- W2792566138 cites W2154857300 @default.
- W2792566138 cites W2165700886 @default.
- W2792566138 cites W2169772248 @default.
- W2792566138 cites W2318679023 @default.
- W2792566138 doi "https://doi.org/10.1002/cbf.3321" @default.
- W2792566138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29368338" @default.
- W2792566138 hasPublicationYear "2018" @default.
- W2792566138 type Work @default.
- W2792566138 sameAs 2792566138 @default.
- W2792566138 citedByCount "7" @default.
- W2792566138 countsByYear W27925661382019 @default.
- W2792566138 countsByYear W27925661382020 @default.
- W2792566138 countsByYear W27925661382021 @default.
- W2792566138 countsByYear W27925661382023 @default.
- W2792566138 crossrefType "journal-article" @default.
- W2792566138 hasAuthorship W2792566138A5001219472 @default.
- W2792566138 hasAuthorship W2792566138A5055441139 @default.
- W2792566138 hasAuthorship W2792566138A5066102428 @default.
- W2792566138 hasAuthorship W2792566138A5079543320 @default.
- W2792566138 hasConcept C104317684 @default.
- W2792566138 hasConcept C119056186 @default.
- W2792566138 hasConcept C127561419 @default.
- W2792566138 hasConcept C145059251 @default.
- W2792566138 hasConcept C153911025 @default.
- W2792566138 hasConcept C171122931 @default.
- W2792566138 hasConcept C181199279 @default.
- W2792566138 hasConcept C185592680 @default.
- W2792566138 hasConcept C2776217839 @default.
- W2792566138 hasConcept C2777723881 @default.
- W2792566138 hasConcept C502942594 @default.
- W2792566138 hasConcept C54009773 @default.
- W2792566138 hasConcept C55493867 @default.
- W2792566138 hasConcept C86803240 @default.
- W2792566138 hasConcept C95444343 @default.
- W2792566138 hasConceptScore W2792566138C104317684 @default.
- W2792566138 hasConceptScore W2792566138C119056186 @default.
- W2792566138 hasConceptScore W2792566138C127561419 @default.
- W2792566138 hasConceptScore W2792566138C145059251 @default.
- W2792566138 hasConceptScore W2792566138C153911025 @default.
- W2792566138 hasConceptScore W2792566138C171122931 @default.
- W2792566138 hasConceptScore W2792566138C181199279 @default.
- W2792566138 hasConceptScore W2792566138C185592680 @default.
- W2792566138 hasConceptScore W2792566138C2776217839 @default.
- W2792566138 hasConceptScore W2792566138C2777723881 @default.
- W2792566138 hasConceptScore W2792566138C502942594 @default.
- W2792566138 hasConceptScore W2792566138C54009773 @default.
- W2792566138 hasConceptScore W2792566138C55493867 @default.
- W2792566138 hasConceptScore W2792566138C86803240 @default.
- W2792566138 hasConceptScore W2792566138C95444343 @default.
- W2792566138 hasFunder F4320324202 @default.
- W2792566138 hasIssue "2" @default.
- W2792566138 hasLocation W27925661381 @default.
- W2792566138 hasLocation W27925661382 @default.