Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792575045> ?p ?o ?g. }
- W2792575045 abstract "Traumatic brain injury (TBI) leads to long-term cognitive, behavioral, affective deficits, and increase neurodegenerative diseases. It is only in recent years that there is growing awareness that TBI even in its milder form poses long term health consequences to not only the brain but to other organ systems. Also, the concept that hormonal signals and neural circuits that originate in the hypothalamus play key roles in regulating skeletal system is gaining recognition based on recent mouse genetic studies. Accordingly, many TBI patients have also presented with hormonal dysfunction, increased skeletal fragility, and increased risk of skeletal diseases. Research from animal models suggests that TBI may exacerbate the activation and inactivation of molecular pathways leading to changes in both osteogenesis and bone destruction. TBI has also been found to induce the formation of heterotopic ossification and increased callus formation at sites of muscle or fracture injury through increased vascularization and activation of systemic factors. Recent studies also suggest that the disruption of endocrine factors and neuropeptides caused by TBI may induce adverse skeletal effects. This review will discuss the long-term consequences of TBI on the skeletal system and TBI-induced signaling pathways that contribute to the formation of ectopic bone, altered fracture healing, and reduced bone mass." @default.
- W2792575045 created "2018-03-29" @default.
- W2792575045 creator A5021950759 @default.
- W2792575045 creator A5054497725 @default.
- W2792575045 creator A5076273186 @default.
- W2792575045 date "2018-03-05" @default.
- W2792575045 modified "2023-10-11" @default.
- W2792575045 title "Long-term Consequences of Traumatic Brain Injury in Bone Metabolism" @default.
- W2792575045 cites W1490022742 @default.
- W2792575045 cites W1528152260 @default.
- W2792575045 cites W1898433457 @default.
- W2792575045 cites W1962090139 @default.
- W2792575045 cites W1964035500 @default.
- W2792575045 cites W1965495835 @default.
- W2792575045 cites W1966279775 @default.
- W2792575045 cites W1967212422 @default.
- W2792575045 cites W1967350279 @default.
- W2792575045 cites W1967739761 @default.
- W2792575045 cites W1976265795 @default.
- W2792575045 cites W1976837794 @default.
- W2792575045 cites W1977236517 @default.
- W2792575045 cites W1978844120 @default.
- W2792575045 cites W1980231989 @default.
- W2792575045 cites W1986501321 @default.
- W2792575045 cites W1988922365 @default.
- W2792575045 cites W1990514899 @default.
- W2792575045 cites W1994530676 @default.
- W2792575045 cites W1998479005 @default.
- W2792575045 cites W1999165373 @default.
- W2792575045 cites W2000038050 @default.
- W2792575045 cites W2000648079 @default.
- W2792575045 cites W2004781279 @default.
- W2792575045 cites W2005850606 @default.
- W2792575045 cites W2007324941 @default.
- W2792575045 cites W2009178440 @default.
- W2792575045 cites W2013583119 @default.
- W2792575045 cites W2015873276 @default.
- W2792575045 cites W2019592328 @default.
- W2792575045 cites W2020349680 @default.
- W2792575045 cites W2020491304 @default.
- W2792575045 cites W2023540371 @default.
- W2792575045 cites W2023661484 @default.
- W2792575045 cites W2026405372 @default.
- W2792575045 cites W2026718935 @default.
- W2792575045 cites W2031838708 @default.
- W2792575045 cites W2034090700 @default.
- W2792575045 cites W2038607522 @default.
- W2792575045 cites W2038682678 @default.
- W2792575045 cites W2040814280 @default.
- W2792575045 cites W2041137495 @default.
- W2792575045 cites W2042836556 @default.
- W2792575045 cites W2044117850 @default.
- W2792575045 cites W2047142702 @default.
- W2792575045 cites W2049483605 @default.
- W2792575045 cites W2049934159 @default.
- W2792575045 cites W2060955024 @default.
- W2792575045 cites W2061793599 @default.
- W2792575045 cites W2062455594 @default.
- W2792575045 cites W2064302505 @default.
- W2792575045 cites W2065588552 @default.
- W2792575045 cites W2067490426 @default.
- W2792575045 cites W2070393006 @default.
- W2792575045 cites W2071722774 @default.
- W2792575045 cites W2073421191 @default.
- W2792575045 cites W2074230216 @default.
- W2792575045 cites W2074571415 @default.
- W2792575045 cites W2076063796 @default.
- W2792575045 cites W2086964102 @default.
- W2792575045 cites W2090020945 @default.
- W2792575045 cites W2091914297 @default.
- W2792575045 cites W2097530528 @default.
- W2792575045 cites W2098792932 @default.
- W2792575045 cites W2099397203 @default.
- W2792575045 cites W2105389636 @default.
- W2792575045 cites W2107135681 @default.
- W2792575045 cites W2108897036 @default.
- W2792575045 cites W2110032258 @default.
- W2792575045 cites W2111240746 @default.
- W2792575045 cites W2115764194 @default.
- W2792575045 cites W2118355184 @default.
- W2792575045 cites W2118622294 @default.
- W2792575045 cites W2120389451 @default.
- W2792575045 cites W2120735170 @default.
- W2792575045 cites W2124810727 @default.
- W2792575045 cites W2129577650 @default.
- W2792575045 cites W2139484243 @default.
- W2792575045 cites W2139816358 @default.
- W2792575045 cites W2140135591 @default.
- W2792575045 cites W2140190076 @default.
- W2792575045 cites W2143669904 @default.
- W2792575045 cites W2145859396 @default.
- W2792575045 cites W2154334945 @default.
- W2792575045 cites W2154767933 @default.
- W2792575045 cites W2157062956 @default.
- W2792575045 cites W2159070583 @default.
- W2792575045 cites W2182850738 @default.
- W2792575045 cites W2191857417 @default.
- W2792575045 cites W2273387714 @default.
- W2792575045 cites W2295009776 @default.
- W2792575045 cites W2331841581 @default.