FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792583558> ?p ?o ?g. }

• W2792583558 endingPage "60" @default.
• W2792583558 startingPage "53" @default.
• W2792583558 abstract "Neoadjuvant chemoradiotherapy (CRT) is used in locally advanced rectal cancer when tumours threaten the circumferential resection margin, with varying response to treatment. This experimental study aimed to identify significantly differentially expressed proteins between patients responding and not responding to CRT, and to validate any proteins of interest. Mass spectrometry (with isobaric tagging for relative quantification) analysis of rectal cancers pre- and post-CRT, and at resection. Validation of proteins of interest was performed by assessing tissue microarray (TMA) immunohistochemistry expression in a further 111 patients with rectal cancer. Proteomic data are available via ProteomeXchange with identifier PXD008436. Reduced abundance of contributing peptide ions for acid ceramidase (AC) (log fold change −1.526, p = 1.17E−02) was observed in CRT responders. Differential expression of AC was confirmed upon analysis of the TMAs. Cancer site expression of AC in stromal cells from post-CRT resection specimens was observed to be relatively low in pathological complete response (p = 0.003), and relatively high with no response to CRT (p = 0.017). AC may be implicated in the response of rectal cancer to CRT. We propose its further assessment as a novel potential biomarker and therapeutic target. There is a need for biomarkers to guide the use of chemoradiotherapy in rectal cancer, as none are in routine clinical use. We have determined acid ceramidase may have a role in radiation response, based on novel proteomic profiling and validation in a wider dataset using tissue microarrays. The ability to predict or improve response would positively select those patients who will derive benefit, prevent delays in the local and systemic management of disease in non-responders, and reduce morbidity associated with chemoradiotherapy." @default.
• W2792583558 created "2018-03-29" @default.
• W2792583558 creator A5014859605 @default.
• W2792583558 creator A5023569261 @default.
• W2792583558 creator A5025032042 @default.
• W2792583558 creator A5025272654 @default.
• W2792583558 creator A5033595881 @default.
• W2792583558 creator A5046007476 @default.
• W2792583558 creator A5048846344 @default.
• W2792583558 creator A5050017532 @default.
• W2792583558 creator A5058302212 @default.
• W2792583558 creator A5060392160 @default.
• W2792583558 creator A5090108906 @default.
• W2792583558 date "2018-05-01" @default.
• W2792583558 modified "2023-10-10" @default.
• W2792583558 title "Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response" @default.
• W2792583558 cites W129238531 @default.
• W2792583558 cites W1642834507 @default.
• W2792583558 cites W1892496998 @default.
• W2792583558 cites W1899767765 @default.
• W2792583558 cites W1965161000 @default.
• W2792583558 cites W1965942536 @default.
• W2792583558 cites W1967222064 @default.
• W2792583558 cites W1974902120 @default.
• W2792583558 cites W1978567452 @default.
• W2792583558 cites W1996916701 @default.
• W2792583558 cites W2002014324 @default.
• W2792583558 cites W2009781085 @default.
• W2792583558 cites W2015425358 @default.
• W2792583558 cites W2026377273 @default.
• W2792583558 cites W2027241722 @default.
• W2792583558 cites W2036069859 @default.
• W2792583558 cites W2037887298 @default.
• W2792583558 cites W2052501640 @default.
• W2792583558 cites W2062809449 @default.
• W2792583558 cites W2073631512 @default.
• W2792583558 cites W2085218834 @default.
• W2792583558 cites W2089714928 @default.
• W2792583558 cites W2107487911 @default.
• W2792583558 cites W2112693548 @default.
• W2792583558 cites W2121649280 @default.
• W2792583558 cites W2125452425 @default.
• W2792583558 cites W2127699440 @default.
• W2792583558 cites W2132565869 @default.
• W2792583558 cites W2135581618 @default.
• W2792583558 cites W2207554953 @default.
• W2792583558 cites W2285203167 @default.
• W2792583558 cites W2516230041 @default.
• W2792583558 cites W2566662178 @default.
• W2792583558 cites W2625828870 @default.
• W2792583558 cites W4231530403 @default.
• W2792583558 cites W60202019 @default.
• W2792583558 doi "https://doi.org/10.1016/j.jprot.2018.02.030" @default.
• W2792583558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29518574" @default.
• W2792583558 hasPublicationYear "2018" @default.
• W2792583558 type Work @default.
• W2792583558 sameAs 2792583558 @default.
• W2792583558 citedByCount "15" @default.
• W2792583558 countsByYear W27925835582018 @default.
• W2792583558 countsByYear W27925835582019 @default.
• W2792583558 countsByYear W27925835582020 @default.
• W2792583558 countsByYear W27925835582021 @default.
• W2792583558 countsByYear W27925835582022 @default.
• W2792583558 countsByYear W27925835582023 @default.
• W2792583558 crossrefType "journal-article" @default.
• W2792583558 hasAuthorship W2792583558A5014859605 @default.
• W2792583558 hasAuthorship W2792583558A5023569261 @default.
• W2792583558 hasAuthorship W2792583558A5025032042 @default.
• W2792583558 hasAuthorship W2792583558A5025272654 @default.
• W2792583558 hasAuthorship W2792583558A5033595881 @default.
• W2792583558 hasAuthorship W2792583558A5046007476 @default.
• W2792583558 hasAuthorship W2792583558A5048846344 @default.
• W2792583558 hasAuthorship W2792583558A5050017532 @default.
• W2792583558 hasAuthorship W2792583558A5058302212 @default.
• W2792583558 hasAuthorship W2792583558A5060392160 @default.
• W2792583558 hasAuthorship W2792583558A5090108906 @default.
• W2792583558 hasConcept C104317684 @default.
• W2792583558 hasConcept C121608353 @default.
• W2792583558 hasConcept C124535831 @default.
• W2792583558 hasConcept C126322002 @default.
• W2792583558 hasConcept C143998085 @default.
• W2792583558 hasConcept C16930146 @default.
• W2792583558 hasConcept C193270364 @default.
• W2792583558 hasConcept C2778424827 @default.
• W2792583558 hasConcept C2781197716 @default.
• W2792583558 hasConcept C46111723 @default.
• W2792583558 hasConcept C502942594 @default.
• W2792583558 hasConcept C509974204 @default.
• W2792583558 hasConcept C526805850 @default.
• W2792583558 hasConcept C55493867 @default.
• W2792583558 hasConcept C71924100 @default.
• W2792583558 hasConcept C86803240 @default.
• W2792583558 hasConceptScore W2792583558C104317684 @default.
• W2792583558 hasConceptScore W2792583558C121608353 @default.
• W2792583558 hasConceptScore W2792583558C124535831 @default.
• W2792583558 hasConceptScore W2792583558C126322002 @default.
• W2792583558 hasConceptScore W2792583558C143998085 @default.
• W2792583558 hasConceptScore W2792583558C16930146 @default.

• next