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- W2792593720 abstract "Abstract γδ T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. γδ T cells are endowed with antitumor activities, and hence several γδ T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of in vitro expanded γδ T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor-infiltrating γδ T cells toward different γδ T cells population with functional activities that help the progression and spread of the tumor. Here, we review the modalities and the possible mechanisms involved in the polarization of tumor-infiltrating γδ T cells upon interaction with several components of the tumor microenvironment and discuss their implications for the manipulation of γδ T cells in cancer immunotherapy." @default.
- W2792593720 created "2018-03-29" @default.
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- W2792593720 date "2017-12-14" @default.
- W2792593720 modified "2023-10-18" @default.
- W2792593720 title "γδ cells and tumor microenvironment: A helpful or a dangerous liason?" @default.
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- W2792593720 doi "https://doi.org/10.1002/jlb.5mr0717-275rr" @default.
- W2792593720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29345336" @default.
- W2792593720 hasPublicationYear "2017" @default.
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