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- W2792598434 abstract "The evolutionarily conserved Hedgehog (Hh) signaling pathway have critical roles in development and homeostasis of tissues. Under physiological conditions, Hh is controlled at different levels via stem cell maintenance and tissue regeneration. Aberrant activation of this signaling pathway may occur in a wide range of human diseases including different types of cancer. In this review we present a concise overview on the key genes composing Hh signaling pathway and provide recent advances on the molecular mechanisms that regulate Hh signaling pathway from extracellular and receptors to the cytoplasmic and nuclear machinery with a highlight on the role of microRNAs. Furthermore, we focus on critical studies demonstrating dysregulation of the Hh pathway in human disease development, and potential therapeutic implications. Finally, we introduce recent therapeutic drugs acting as Shh signaling pathway inhibitors, including those in clinical trials and preclinical studies." @default.
- W2792598434 created "2018-03-29" @default.
- W2792598434 creator A5019511061 @default.
- W2792598434 creator A5025513058 @default.
- W2792598434 creator A5027057043 @default.
- W2792598434 date "2018-03-07" @default.
- W2792598434 modified "2023-10-18" @default.
- W2792598434 title "Hedgehog signaling pathway: Epigenetic regulation and role in disease and cancer development" @default.
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- W2792598434 doi "https://doi.org/10.1002/jcp.26506" @default.
- W2792598434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29380372" @default.
- W2792598434 hasPublicationYear "2018" @default.
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