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- W2792629749 abstract "Abstract Cryptococcus neoformans and Cryptococcus gattii cause life-threatening meningoencephalitis and pneumonia in immunosuppressed and immunocompetent individuals. Given the structural differences of major polysaccharide glucuronoxylomannan (GXM) between C. neoformans and C. gattii , it remains unclear that how innate immune system recognizes GXM. Here, we report that C-type lectin receptor Dectin-3 (MCL encoded by Clec4d) is a direct receptor for GXMs from C. neoformans serotype AD ( C.n -AD) and C. gattii serotype B ( C.g -B). GXMs from C.n -AD and C.g -B activated both NF-κB and ERK pathways to induce the pro-inflammatory cytokine production, whereas it was completely abolished due to deficiency of Dectin-3 or its downstream adaptor protein CARD9. Upon pulmonary C.n -AD and C.g -B infection, Dectin-3- and CARD9-deficient mice were highly susceptible and showed augmented lung injury due to impairment of alveolar macrophage accumulation and killing activities. These results demonstrate that Dectin-3 contributes to host immunity against Cryptococcus infection through selectively recognizingGXM." @default.
- W2792629749 created "2018-03-29" @default.
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- W2792629749 date "2018-03-13" @default.
- W2792629749 modified "2023-10-16" @default.
- W2792629749 title "Dectin-3 recognizes cryptococcal glucuronoxylomannan to initiate host defense against cryptococcosis" @default.
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- W2792629749 doi "https://doi.org/10.1101/281790" @default.
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