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- W2792632645 abstract "Abstract Dietary restriction (DR) increases median life span and protects against age‐related disease. Improved longevity can be achieved by restriction of dietary energy, protein, or amino acids (AAs), such as methionine (Met). Met requirements have been defined using methodologies that measure the dose response to Met when all other dietary variables are held constant and with outcomes focused on protein turnover. Here, we cover protein and sulfur AA requirements and discuss the terms “deficient,” “optimal,” and “excess” and how these need to be considered. We additionally discuss the effect of methyl‐donating compounds on sulfur AA metabolism and outcomes. We will discuss how the mechanistic target of rapamycin complex 1 (mTORC1) signaling network regulates protein turnover, lipogenesis and cell growth, proliferation, differentiation, and metabolism in response to hormones, AAs, and cellular energy status. Inhibition of mTORC1 signaling with rapamycin or genetic mutation increases median life span in model organisms, and mTORC1 inhibition may be responsible for some of the life span–extending effects of DR. Finally, we discuss how the sulfur AAs may regulate aspects of reactive oxygen species (ROS) mitigation. Overall, we suggest that approaches evaluating AA intake need to consider whole‐body protein synthesis and measures related to tissue‐specific and whole‐body metabolism that have been associated with longevity." @default.
- W2792632645 created "2018-03-29" @default.
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- W2792632645 date "2018-01-24" @default.
- W2792632645 modified "2023-09-25" @default.
- W2792632645 title "Lessons from animal nutritionists: dietary amino acid requirement studies and considerations for healthy aging studies" @default.
- W2792632645 cites W101827760 @default.
- W2792632645 cites W1271996592 @default.
- W2792632645 cites W1563387341 @default.
- W2792632645 cites W1590203635 @default.
- W2792632645 cites W1632132781 @default.
- W2792632645 cites W1784651233 @default.
- W2792632645 cites W1899635721 @default.
- W2792632645 cites W1908477062 @default.
- W2792632645 cites W1909189931 @default.
- W2792632645 cites W1925815478 @default.
- W2792632645 cites W1926324062 @default.
- W2792632645 cites W1960176334 @default.
- W2792632645 cites W1964876365 @default.
- W2792632645 cites W1965615149 @default.
- W2792632645 cites W1966132436 @default.
- W2792632645 cites W1970937302 @default.
- W2792632645 cites W1972079299 @default.
- W2792632645 cites W1976395092 @default.
- W2792632645 cites W2003593490 @default.
- W2792632645 cites W2010583480 @default.
- W2792632645 cites W2012385028 @default.
- W2792632645 cites W2013421577 @default.
- W2792632645 cites W2013894349 @default.
- W2792632645 cites W2020902432 @default.
- W2792632645 cites W2022349505 @default.
- W2792632645 cites W2033414384 @default.
- W2792632645 cites W2035205542 @default.
- W2792632645 cites W2044073186 @default.
- W2792632645 cites W2053493267 @default.
- W2792632645 cites W2057766506 @default.
- W2792632645 cites W2058799973 @default.
- W2792632645 cites W2060607801 @default.
- W2792632645 cites W2061219362 @default.
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- W2792632645 cites W2066869137 @default.
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- W2792632645 cites W2078410199 @default.
- W2792632645 cites W2081397294 @default.
- W2792632645 cites W2086171302 @default.
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- W2792632645 doi "https://doi.org/10.1111/nyas.13546" @default.
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