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- W2792665672 abstract "Trigeminal autonomic cephalalgia (TAC) encompasses 4 unique primary headache types: cluster headache, paroxysmal hemicrania, hemicrania continua, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms. They are grouped on the basis of their shared clinical features of unilateral headache of varying durations and ipsilateral cranial autonomic symptoms. The shared clinical features reflect the underlying activation of the trigeminal–autonomic reflex. The treatment for TACs has been limited and not specific to the underlying pathogenesis. There is a proportion of patients who are refractory or intolerant to the current standard medical treatment. From instrumental bench work research and neuroimaging studies, there are new therapeutic targets identified in TACs. Treatment has become more targeted and aimed towards the pathogenesis of the conditions. The therapeutic targets range from the macroscopic and structural level down to the molecular and receptor level. The structural targets for surgical and noninvasive neuromodulation include central neuromodulation targets: posterior hypothalamus and, high cervical nerves, and peripheral neuromodulation targets: occipital nerves, sphenopalatine ganglion, and vagus nerve. In this review, we will also discuss the neuropeptide and molecular targets, in particular, calcitonin gene-related peptide, somatostatin, transient receptor potential vanilloid-1 receptor, nitric oxide, melatonin, orexin, pituitary adenylate cyclase-activating polypeptide, and glutamate." @default.
- W2792665672 created "2018-03-29" @default.
- W2792665672 creator A5018165002 @default.
- W2792665672 creator A5031779481 @default.
- W2792665672 date "2018-03-07" @default.
- W2792665672 modified "2023-09-25" @default.
- W2792665672 title "Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias" @default.
- W2792665672 cites W11563888 @default.
- W2792665672 cites W1568859538 @default.
- W2792665672 cites W161720557 @default.
- W2792665672 cites W1639910105 @default.
- W2792665672 cites W1662741476 @default.
- W2792665672 cites W177672350 @default.
- W2792665672 cites W1883906051 @default.
- W2792665672 cites W1932300422 @default.
- W2792665672 cites W1963715692 @default.
- W2792665672 cites W1970860218 @default.
- W2792665672 cites W1975317244 @default.
- W2792665672 cites W1976422486 @default.
- W2792665672 cites W1981295820 @default.
- W2792665672 cites W1981423842 @default.
- W2792665672 cites W1981522081 @default.
- W2792665672 cites W1981547344 @default.
- W2792665672 cites W1981954594 @default.
- W2792665672 cites W1982387055 @default.
- W2792665672 cites W1983783303 @default.
- W2792665672 cites W1989370288 @default.
- W2792665672 cites W1991516705 @default.
- W2792665672 cites W1992395719 @default.
- W2792665672 cites W1994771940 @default.
- W2792665672 cites W1996383079 @default.
- W2792665672 cites W1997744254 @default.
- W2792665672 cites W1997797053 @default.
- W2792665672 cites W1998153022 @default.
- W2792665672 cites W2000933881 @default.
- W2792665672 cites W2004501096 @default.
- W2792665672 cites W2005840740 @default.
- W2792665672 cites W2007392454 @default.
- W2792665672 cites W2009862992 @default.
- W2792665672 cites W2010394405 @default.
- W2792665672 cites W2011331569 @default.
- W2792665672 cites W2017446239 @default.
- W2792665672 cites W2019591295 @default.
- W2792665672 cites W2019729730 @default.
- W2792665672 cites W2024183457 @default.
- W2792665672 cites W2025662749 @default.
- W2792665672 cites W2026691627 @default.
- W2792665672 cites W2027121504 @default.
- W2792665672 cites W2028106167 @default.
- W2792665672 cites W2029476307 @default.
- W2792665672 cites W2029615725 @default.
- W2792665672 cites W2031158451 @default.
- W2792665672 cites W2031995863 @default.
- W2792665672 cites W2037275755 @default.
- W2792665672 cites W2039264589 @default.
- W2792665672 cites W2041499421 @default.
- W2792665672 cites W2044869640 @default.
- W2792665672 cites W2047413724 @default.
- W2792665672 cites W2048524109 @default.
- W2792665672 cites W2049249365 @default.
- W2792665672 cites W2052101966 @default.
- W2792665672 cites W2053191125 @default.
- W2792665672 cites W2056084209 @default.
- W2792665672 cites W2056321017 @default.
- W2792665672 cites W2056461876 @default.
- W2792665672 cites W2056550385 @default.
- W2792665672 cites W2057590372 @default.
- W2792665672 cites W2060075702 @default.
- W2792665672 cites W2061529241 @default.
- W2792665672 cites W2063179894 @default.
- W2792665672 cites W2063736647 @default.
- W2792665672 cites W2064170874 @default.
- W2792665672 cites W2068411567 @default.
- W2792665672 cites W2069062706 @default.
- W2792665672 cites W2069874361 @default.
- W2792665672 cites W2069950730 @default.
- W2792665672 cites W2070298093 @default.
- W2792665672 cites W2071345695 @default.
- W2792665672 cites W2072601405 @default.
- W2792665672 cites W2076402267 @default.
- W2792665672 cites W2077270511 @default.
- W2792665672 cites W2079802090 @default.
- W2792665672 cites W2080236541 @default.
- W2792665672 cites W2080328086 @default.
- W2792665672 cites W2081795544 @default.
- W2792665672 cites W2083821823 @default.
- W2792665672 cites W2084884436 @default.
- W2792665672 cites W2085595272 @default.
- W2792665672 cites W2088009207 @default.
- W2792665672 cites W2090276452 @default.
- W2792665672 cites W2091117223 @default.
- W2792665672 cites W2091636526 @default.
- W2792665672 cites W2096984244 @default.
- W2792665672 cites W2097764704 @default.
- W2792665672 cites W2098813714 @default.
- W2792665672 cites W2108345220 @default.
- W2792665672 cites W2109293109 @default.
- W2792665672 cites W2111533660 @default.