Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792691631> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2792691631 endingPage "56" @default.
- W2792691631 startingPage "47" @default.
- W2792691631 abstract "Orodispersible tablets (ODTs) emerged as dosage forms recommended for special groups of patients like pediatrics or geriatrics, due to their multiple advantages. Among their critical quality attributes, palatability determines patient acceptance, with high impact on treatment efficacy. The aim of this study was to develop an instrumental method to assess in vivo disintegration time and palatability of ODTs. The formulation factors that can influence palatability were refined through an experimental design. The most important ones were taken forward and a calibration set was prepared for multivariate calibration model development. The ODTs were tested for their pharmaceutical properties, texture profile, followed by in vivo disintegration and palatability characteristics assessed by a panel of 16 healthy volunteers. Acceptability was correlated to high palatability scores, sweet taste and long disintegration time and negatively correlated to with the bitter taste and a voluminous residue. Results revealed the importance of choosing the right type of filler or filler ratio for the oral disintegration time and associated mouth feel. The calibration set included formulations with different ratios of mannitol and microcrystalline cellulose as fillers. Regression models were built by correlating the texture profiles to the in vivo evaluation parameters. The model performance was good on both external prediction set formulations and on marketed ODTs, with good predictive capacity (Q2 > 0.7) for most of the subjective ODTs characteristics: in vivo disintegration time, residual volume and palatability." @default.
- W2792691631 created "2018-03-29" @default.
- W2792691631 creator A5025851990 @default.
- W2792691631 creator A5035200518 @default.
- W2792691631 creator A5050241795 @default.
- W2792691631 creator A5072208148 @default.
- W2792691631 creator A5074925623 @default.
- W2792691631 creator A5077377638 @default.
- W2792691631 date "2018-04-01" @default.
- W2792691631 modified "2023-10-17" @default.
- W2792691631 title "Assessment of oral formulation-dependent characteristics of orodispersible tablets using texture profiles and multivariate data analysis" @default.
- W2792691631 cites W1968209760 @default.
- W2792691631 cites W1974055426 @default.
- W2792691631 cites W1980041206 @default.
- W2792691631 cites W2006666143 @default.
- W2792691631 cites W2024190072 @default.
- W2792691631 cites W2044572427 @default.
- W2792691631 cites W2049660697 @default.
- W2792691631 cites W2051897796 @default.
- W2792691631 cites W2075854967 @default.
- W2792691631 cites W2084745450 @default.
- W2792691631 cites W2089468765 @default.
- W2792691631 cites W2148034818 @default.
- W2792691631 cites W2163334892 @default.
- W2792691631 cites W2218320402 @default.
- W2792691631 cites W2463225402 @default.
- W2792691631 cites W2581624369 @default.
- W2792691631 cites W2587169644 @default.
- W2792691631 doi "https://doi.org/10.1016/j.jpba.2018.01.040" @default.
- W2792691631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29414018" @default.
- W2792691631 hasPublicationYear "2018" @default.
- W2792691631 type Work @default.
- W2792691631 sameAs 2792691631 @default.
- W2792691631 citedByCount "19" @default.
- W2792691631 countsByYear W27926916312018 @default.
- W2792691631 countsByYear W27926916312019 @default.
- W2792691631 countsByYear W27926916312020 @default.
- W2792691631 countsByYear W27926916312021 @default.
- W2792691631 countsByYear W27926916312022 @default.
- W2792691631 countsByYear W27926916312023 @default.
- W2792691631 crossrefType "journal-article" @default.
- W2792691631 hasAuthorship W2792691631A5025851990 @default.
- W2792691631 hasAuthorship W2792691631A5035200518 @default.
- W2792691631 hasAuthorship W2792691631A5050241795 @default.
- W2792691631 hasAuthorship W2792691631A5072208148 @default.
- W2792691631 hasAuthorship W2792691631A5074925623 @default.
- W2792691631 hasAuthorship W2792691631A5077377638 @default.
- W2792691631 hasConcept C105795698 @default.
- W2792691631 hasConcept C161584116 @default.
- W2792691631 hasConcept C172873279 @default.
- W2792691631 hasConcept C178790620 @default.
- W2792691631 hasConcept C185592680 @default.
- W2792691631 hasConcept C2779251873 @default.
- W2792691631 hasConcept C2779351475 @default.
- W2792691631 hasConcept C31903555 @default.
- W2792691631 hasConcept C33923547 @default.
- W2792691631 hasConcept C43617362 @default.
- W2792691631 hasConcept C8868529 @default.
- W2792691631 hasConceptScore W2792691631C105795698 @default.
- W2792691631 hasConceptScore W2792691631C161584116 @default.
- W2792691631 hasConceptScore W2792691631C172873279 @default.
- W2792691631 hasConceptScore W2792691631C178790620 @default.
- W2792691631 hasConceptScore W2792691631C185592680 @default.
- W2792691631 hasConceptScore W2792691631C2779251873 @default.
- W2792691631 hasConceptScore W2792691631C2779351475 @default.
- W2792691631 hasConceptScore W2792691631C31903555 @default.
- W2792691631 hasConceptScore W2792691631C33923547 @default.
- W2792691631 hasConceptScore W2792691631C43617362 @default.
- W2792691631 hasConceptScore W2792691631C8868529 @default.
- W2792691631 hasLocation W27926916311 @default.
- W2792691631 hasLocation W27926916312 @default.
- W2792691631 hasOpenAccess W2792691631 @default.
- W2792691631 hasPrimaryLocation W27926916311 @default.
- W2792691631 hasRelatedWork W1865535982 @default.
- W2792691631 hasRelatedWork W1865553564 @default.
- W2792691631 hasRelatedWork W2043536693 @default.
- W2792691631 hasRelatedWork W2116980345 @default.
- W2792691631 hasRelatedWork W2179899926 @default.
- W2792691631 hasRelatedWork W2255731922 @default.
- W2792691631 hasRelatedWork W2348078106 @default.
- W2792691631 hasRelatedWork W2885208938 @default.
- W2792691631 hasRelatedWork W3136745377 @default.
- W2792691631 hasRelatedWork W790024086 @default.
- W2792691631 hasVolume "152" @default.
- W2792691631 isParatext "false" @default.
- W2792691631 isRetracted "false" @default.
- W2792691631 magId "2792691631" @default.
- W2792691631 workType "article" @default.