Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792692753> ?p ?o ?g. }
- W2792692753 endingPage "904" @default.
- W2792692753 startingPage "899" @default.
- W2792692753 abstract "Background and Purpose— It has been hypothesized that cerebral small vessel disease (SVD) and chronic renal impairment may be part of a multisystem small-vessel disorder, but their association may simply be as a result of shared risk factors (eg, hypertension) rather than to a systemic susceptibility to premature SVD. However, most previous studies were hospital based, most had inadequate adjustment for hypertension, many were confined to patients with lacunar stroke, and none stratified by age. Methods— In a population-based study of transient ischemic attack and ischemic stroke (OXVASC [Oxford Vascular Study]), we evaluated the magnetic resonance imaging markers of cerebral SVD, including lacunes, white matter hyperintensities, cerebral microbleeds, and enlarged perivascular space. We studied the age-specific associations of renal impairment (estimated glomerular filtration rate <60 mL/min per 1.73 m 2 ) and total SVD burden (total SVD score) adjusting for age, sex, vascular risk factors, and premorbid blood pressure (mean blood pressure during 15 years preevent). Results— Of 1080 consecutive patients, 1028 (95.2%) had complete magnetic resonance imaging protocol and creatinine measured at baseline. Renal impairment was associated with total SVD score (odds ratio [OR], 2.16; 95% confidence interval [CI], 1.69–2.75; P <0.001), but only at age <60 years (<60 years: OR, 3.97; 95% CI, 1.69–9.32; P =0.002; 60–79 years: OR, 1.01; 95% CI, 0.72–1.41; P =0.963; ≥80 years: OR, 0.95; 95% CI, 0.59–1.54; P =0.832). The overall association of renal impairment and total SVD score was also attenuated after adjustment for age, sex, history of hypertension, diabetes mellitus, and premorbid average systolic blood pressure (adjusted OR, 0.76; 95% CI, 0.56–1.02; P =0.067), but the independent association of renal impairment and total SVD score at age <60 years was maintained (adjusted OR, 3.11; 95% CI, 1.21–7.98; P =0.018). Associations of renal impairment and SVD were consistent for each SVD marker at age <60 years but were strongest for cerebral microbleeds (OR, 5.84; 95% CI, 1.45–23.53; P =0.013) and moderate–severe periventricular white matter hyperintensities (OR, 6.28; 95% CI, 1.54–25.63; P =0.010). Conclusions— The association of renal impairment and cerebral SVD was attenuated with adjustment for shared risk factors at older ages, but remained at younger ages, consistent with a shared susceptibility to premature disease." @default.
- W2792692753 created "2018-03-29" @default.
- W2792692753 creator A5015215059 @default.
- W2792692753 creator A5015842090 @default.
- W2792692753 creator A5017405351 @default.
- W2792692753 creator A5018531683 @default.
- W2792692753 creator A5019056174 @default.
- W2792692753 creator A5056981373 @default.
- W2792692753 creator A5085820448 @default.
- W2792692753 date "2018-04-01" @default.
- W2792692753 modified "2023-09-27" @default.
- W2792692753 title "Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke" @default.
- W2792692753 cites W1752743784 @default.
- W2792692753 cites W1987672637 @default.
- W2792692753 cites W2003944176 @default.
- W2792692753 cites W2007951064 @default.
- W2792692753 cites W2017522190 @default.
- W2792692753 cites W2041993475 @default.
- W2792692753 cites W2055864845 @default.
- W2792692753 cites W2078800480 @default.
- W2792692753 cites W2085743961 @default.
- W2792692753 cites W2091931051 @default.
- W2792692753 cites W2102741113 @default.
- W2792692753 cites W2103868761 @default.
- W2792692753 cites W2106849104 @default.
- W2792692753 cites W2113315322 @default.
- W2792692753 cites W2119527709 @default.
- W2792692753 cites W2148568506 @default.
- W2792692753 cites W2150548551 @default.
- W2792692753 cites W2157032372 @default.
- W2792692753 cites W2157157003 @default.
- W2792692753 cites W2158742097 @default.
- W2792692753 cites W2616001926 @default.
- W2792692753 doi "https://doi.org/10.1161/strokeaha.117.019650" @default.
- W2792692753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5895118" @default.
- W2792692753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29523652" @default.
- W2792692753 hasPublicationYear "2018" @default.
- W2792692753 type Work @default.
- W2792692753 sameAs 2792692753 @default.
- W2792692753 citedByCount "27" @default.
- W2792692753 countsByYear W27926927532019 @default.
- W2792692753 countsByYear W27926927532020 @default.
- W2792692753 countsByYear W27926927532021 @default.
- W2792692753 countsByYear W27926927532022 @default.
- W2792692753 countsByYear W27926927532023 @default.
- W2792692753 crossrefType "journal-article" @default.
- W2792692753 hasAuthorship W2792692753A5015215059 @default.
- W2792692753 hasAuthorship W2792692753A5015842090 @default.
- W2792692753 hasAuthorship W2792692753A5017405351 @default.
- W2792692753 hasAuthorship W2792692753A5018531683 @default.
- W2792692753 hasAuthorship W2792692753A5019056174 @default.
- W2792692753 hasAuthorship W2792692753A5056981373 @default.
- W2792692753 hasAuthorship W2792692753A5085820448 @default.
- W2792692753 hasBestOaLocation W27926927531 @default.
- W2792692753 hasConcept C126322002 @default.
- W2792692753 hasConcept C126838900 @default.
- W2792692753 hasConcept C127413603 @default.
- W2792692753 hasConcept C143409427 @default.
- W2792692753 hasConcept C146638467 @default.
- W2792692753 hasConcept C156957248 @default.
- W2792692753 hasConcept C159641895 @default.
- W2792692753 hasConcept C164705383 @default.
- W2792692753 hasConcept C2778653478 @default.
- W2792692753 hasConcept C2779285336 @default.
- W2792692753 hasConcept C2780645631 @default.
- W2792692753 hasConcept C2908647359 @default.
- W2792692753 hasConcept C3020199598 @default.
- W2792692753 hasConcept C44249647 @default.
- W2792692753 hasConcept C541997718 @default.
- W2792692753 hasConcept C71924100 @default.
- W2792692753 hasConcept C78519656 @default.
- W2792692753 hasConcept C84393581 @default.
- W2792692753 hasConcept C99454951 @default.
- W2792692753 hasConceptScore W2792692753C126322002 @default.
- W2792692753 hasConceptScore W2792692753C126838900 @default.
- W2792692753 hasConceptScore W2792692753C127413603 @default.
- W2792692753 hasConceptScore W2792692753C143409427 @default.
- W2792692753 hasConceptScore W2792692753C146638467 @default.
- W2792692753 hasConceptScore W2792692753C156957248 @default.
- W2792692753 hasConceptScore W2792692753C159641895 @default.
- W2792692753 hasConceptScore W2792692753C164705383 @default.
- W2792692753 hasConceptScore W2792692753C2778653478 @default.
- W2792692753 hasConceptScore W2792692753C2779285336 @default.
- W2792692753 hasConceptScore W2792692753C2780645631 @default.
- W2792692753 hasConceptScore W2792692753C2908647359 @default.
- W2792692753 hasConceptScore W2792692753C3020199598 @default.
- W2792692753 hasConceptScore W2792692753C44249647 @default.
- W2792692753 hasConceptScore W2792692753C541997718 @default.
- W2792692753 hasConceptScore W2792692753C71924100 @default.
- W2792692753 hasConceptScore W2792692753C78519656 @default.
- W2792692753 hasConceptScore W2792692753C84393581 @default.
- W2792692753 hasConceptScore W2792692753C99454951 @default.
- W2792692753 hasIssue "4" @default.
- W2792692753 hasLocation W27926927531 @default.
- W2792692753 hasLocation W27926927532 @default.
- W2792692753 hasLocation W27926927533 @default.
- W2792692753 hasLocation W27926927534 @default.
- W2792692753 hasLocation W27926927535 @default.