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• W2792725988 abstract "Research on aging has recently surged, with a primary focus on developing druggable targets for interventions. To date, drug-based approaches have shown evidence of enhancing health in old age, but without clear evidence for extending maximal life span. Progress in cell, tissue, and organ replacements is providing – at least in principle – an alternative to pharmacological approaches that could undo age-related damage. However, whether cell replacement is also applicable to the brain, due to possible loss of self-identity, is an open question. Recent breakthroughs in brain-cell transplant studies show that new neurons can integrate in the adult neocortex, suggesting that, combined with normal plasticity, progressive cell replacements are possible. While major challenges remain, rejuvenation of the brain via cell replacement to reverse age-related damage and functional decline appears to be as valid an approach as it is for most other organs and tissues. Current antiaging strategies focusing on druggable targets have met with relatively limited success to date. Replacement of cells, tissues, and organs could provide an alternative means for targeting age-induced damage and potentially eliminating some of it. However, before this is a viable option, numerous challenges need to be addressed. Most notably, whether the brain, which defines our self-identity, is amenable to replacement therapies is unclear. Here, we consider whether progressive cell replacement is a potential approach to reverse brain aging without grossly altering function. We focus mainly on the neocortex, seat of our highest cognitive functions, because of abundant knowledge on neocortical development, plasticity, and how the neocortex can functionally incorporate new neurons. We outline the primary challenges for brain cell replacement, and key areas that require further investigation. Current antiaging strategies focusing on druggable targets have met with relatively limited success to date. Replacement of cells, tissues, and organs could provide an alternative means for targeting age-induced damage and potentially eliminating some of it. However, before this is a viable option, numerous challenges need to be addressed. Most notably, whether the brain, which defines our self-identity, is amenable to replacement therapies is unclear. Here, we consider whether progressive cell replacement is a potential approach to reverse brain aging without grossly altering function. We focus mainly on the neocortex, seat of our highest cognitive functions, because of abundant knowledge on neocortical development, plasticity, and how the neocortex can functionally incorporate new neurons. We outline the primary challenges for brain cell replacement, and key areas that require further investigation." @default.
• W2792725988 created "2018-03-29" @default.
• W2792725988 creator A5012398734 @default.
• W2792725988 creator A5070035937 @default.
• W2792725988 date "2018-05-01" @default.
• W2792725988 modified "2023-09-25" @default.
• W2792725988 title "Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities" @default.
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