FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2792731540> ?p ?o ?g. }

• W2792731540 endingPage "92S.e2" @default.
• W2792731540 startingPage "82S" @default.
• W2792731540 abstract "ObjectiveThe pathogenesis of aortic aneurysm (AA) is associated with chronic inflammation in the aortic wall with increased levels of matrix metalloproteinases (MMPs). Clarithromycin (CAM) has been reported to suppresses MMP activity. In this study, we investigated whether CAM could prevent the formation and rupture of AA.MethodsMale apolipoprotein E-deficient mice (28-30 weeks of age) were infused with angiotensin II for 28 days. CAM (100 mg/kg/d) or saline (as a control) was administered orally to the mice every day (CAM group, n = 13; control group, n = 13). After the administration period, the aortic diameter, elastin content, macrophage infiltration, MMP levels, and levels of inflammatory cytokines, including nuclear factor κB (NF-κB), were measured.ResultsThe aortic diameter was significantly suppressed in the CAM group (P < .001). No rupture death was observed in the CAM group in contrast to five deaths (38%) in the control group (P < .01). CAM significantly suppressed the degradation of aortic elastin (56.3% vs 16.5%; P < .001) and decreased the infiltration of inflammatory macrophages (0.05 vs 0.16; P < .01). Compared with the controls, the enzymatic activity of MMP-2 and MMP-9 was significantly reduced in the CAM group (MMP-2, 0.15 vs 0.56 [P < .01]; MMP-9, 0.12 vs 0.60 [P < .01]), and the levels of interleukin 1β (346.6 vs 1066.0; P < .05), interleukin 6 (128.4 vs 346.2; P < .05), and phosphorylation of NF-κB were also decreased (0.3 vs 2.0; P < .01).ConclusionsCAM suppressed the progression and rupture of AA through the suppression of inflammatory macrophage infiltration, a reduction in MMP-2 and MMP-9 activity, and the inhibition of elastin degradation associated with the suppression of NF-κB phosphorylation." @default.
• W2792731540 created "2018-03-29" @default.
• W2792731540 creator A5004299013 @default.
• W2792731540 creator A5004611527 @default.
• W2792731540 creator A5016518151 @default.
• W2792731540 creator A5018539407 @default.
• W2792731540 creator A5032044936 @default.
• W2792731540 creator A5045619208 @default.
• W2792731540 creator A5070443746 @default.
• W2792731540 creator A5073738648 @default.
• W2792731540 creator A5079855935 @default.
• W2792731540 date "2018-12-01" @default.
• W2792731540 modified "2023-10-03" @default.
• W2792731540 title "The oral administration of clarithromycin prevents the progression and rupture of aortic aneurysm" @default.
• W2792731540 cites W1483497655 @default.
• W2792731540 cites W1849189332 @default.
• W2792731540 cites W1968500926 @default.
• W2792731540 cites W1971448058 @default.
• W2792731540 cites W1983575289 @default.
• W2792731540 cites W1985859986 @default.
• W2792731540 cites W1987280936 @default.
• W2792731540 cites W1990538517 @default.
• W2792731540 cites W2002529382 @default.
• W2792731540 cites W2017409538 @default.
• W2792731540 cites W2024896716 @default.
• W2792731540 cites W2028543411 @default.
• W2792731540 cites W2047791801 @default.
• W2792731540 cites W2055805420 @default.
• W2792731540 cites W2061091803 @default.
• W2792731540 cites W2065974271 @default.
• W2792731540 cites W2080373577 @default.
• W2792731540 cites W2084838040 @default.
• W2792731540 cites W2088924188 @default.
• W2792731540 cites W2097672870 @default.
• W2792731540 cites W2101316389 @default.
• W2792731540 cites W2121246362 @default.
• W2792731540 cites W2155854521 @default.
• W2792731540 cites W2157824066 @default.
• W2792731540 cites W2163860581 @default.
• W2792731540 cites W2192436159 @default.
• W2792731540 cites W2346720032 @default.
• W2792731540 cites W2915142973 @default.
• W2792731540 cites W9129716 @default.
• W2792731540 doi "https://doi.org/10.1016/j.jvs.2017.12.047" @default.
• W2792731540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29550174" @default.
• W2792731540 hasPublicationYear "2018" @default.
• W2792731540 type Work @default.
• W2792731540 sameAs 2792731540 @default.
• W2792731540 citedByCount "4" @default.
• W2792731540 countsByYear W27927315402018 @default.
• W2792731540 countsByYear W27927315402021 @default.
• W2792731540 countsByYear W27927315402023 @default.
• W2792731540 crossrefType "journal-article" @default.
• W2792731540 hasAuthorship W2792731540A5004299013 @default.
• W2792731540 hasAuthorship W2792731540A5004611527 @default.
• W2792731540 hasAuthorship W2792731540A5016518151 @default.
• W2792731540 hasAuthorship W2792731540A5018539407 @default.
• W2792731540 hasAuthorship W2792731540A5032044936 @default.
• W2792731540 hasAuthorship W2792731540A5045619208 @default.
• W2792731540 hasAuthorship W2792731540A5070443746 @default.
• W2792731540 hasAuthorship W2792731540A5073738648 @default.
• W2792731540 hasAuthorship W2792731540A5079855935 @default.
• W2792731540 hasBestOaLocation W27927315401 @default.
• W2792731540 hasConcept C109523444 @default.
• W2792731540 hasConcept C126322002 @default.
• W2792731540 hasConcept C134018914 @default.
• W2792731540 hasConcept C142724271 @default.
• W2792731540 hasConcept C2776409635 @default.
• W2792731540 hasConcept C2776914184 @default.
• W2792731540 hasConcept C2776962512 @default.
• W2792731540 hasConcept C2777397205 @default.
• W2792731540 hasConcept C2778690821 @default.
• W2792731540 hasConcept C2779869378 @default.
• W2792731540 hasConcept C2780942790 @default.
• W2792731540 hasConcept C71924100 @default.
• W2792731540 hasConcept C74172505 @default.
• W2792731540 hasConcept C90924648 @default.
• W2792731540 hasConceptScore W2792731540C109523444 @default.
• W2792731540 hasConceptScore W2792731540C126322002 @default.
• W2792731540 hasConceptScore W2792731540C134018914 @default.
• W2792731540 hasConceptScore W2792731540C142724271 @default.
• W2792731540 hasConceptScore W2792731540C2776409635 @default.
• W2792731540 hasConceptScore W2792731540C2776914184 @default.
• W2792731540 hasConceptScore W2792731540C2776962512 @default.
• W2792731540 hasConceptScore W2792731540C2777397205 @default.
• W2792731540 hasConceptScore W2792731540C2778690821 @default.
• W2792731540 hasConceptScore W2792731540C2779869378 @default.
• W2792731540 hasConceptScore W2792731540C2780942790 @default.
• W2792731540 hasConceptScore W2792731540C71924100 @default.
• W2792731540 hasConceptScore W2792731540C74172505 @default.
• W2792731540 hasConceptScore W2792731540C90924648 @default.
• W2792731540 hasIssue "6" @default.
• W2792731540 hasLocation W27927315401 @default.
• W2792731540 hasLocation W27927315402 @default.
• W2792731540 hasOpenAccess W2792731540 @default.
• W2792731540 hasPrimaryLocation W27927315401 @default.
• W2792731540 hasRelatedWork W1983012135 @default.
• W2792731540 hasRelatedWork W2009877402 @default.

• next